国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (4): 463-471.doi: 10.7518/gjkq.2023064
Yu Lerong1(),Li Xiangwei1(),Ai Hong2
摘要:
牙髓干细胞是存在于牙髓组织中的一种牙源性未分化间充质干细胞,具有强大的自我更新能力和多向分化潜能,可在特定刺激条件下分化为成骨细胞、软骨细胞、成牙本质细胞、脂肪细胞、神经细胞、肌细胞以及肝细胞等,为其应用于治疗各种组织缺损和修复提供了新的临床思路和方法。牙髓干细胞在体外传代和扩增的过程中不可避免地会出现增殖速度减慢、细胞衰老和多能性减退等干性降低的表现,这严重阻碍牙髓干细胞在组织工程中的应用。如何克服牙髓干细胞干性维持欠佳的不足,以及如何维持牙髓干细胞的干性等问题在组织工程研究中受到广泛关注。本文对牙髓干细胞干性维持的意义,维持方法(包括低温保存、培养维度、低氧环境、应用细胞因子等)及其调控的分子机制等方面的研究进展进行综述。
中图分类号:
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