国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (6): 737-744.doi: 10.7518/gjkq.2021088
• 综述 • 上一篇
摘要:
骨缺损是口腔颌面部疾病常见的并发症,唇腭裂及慢性牙周炎等均可造成骨缺损,影响面部的功能及美观。而具备多向分化潜能和自我更新能力等良好生物学特性的牙髓干细胞(DPSC)的成骨分化潜能可为骨缺损的修复提供新思路,具有重要的临床转化价值。研究发现:DPSC的成骨分化受到多种因素的调控,通过向DPSC的培养体系中添加药物来诱导细胞的成骨分化是常用的方法之一。一方面,药物可以在体外诱导DPSC的成骨分化,另一方面可以将药物与DPSC在临床上联合应用,明确哪些药物对DPSC成骨分化具有促进作用,对其转化及应用具有重要的意义。本文就相关药物对DPSC成骨分化调控的研究进展进行综述,以期为DPSC在再生医学及临床应用方面的研究提供新的策略。
中图分类号:
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