生物可降解镁基材料在颅颌面外科的应用及其研究进展

doi:10.7518/gjkq.2024004

摘要/Abstract

摘要：

作为一种新型骨植入材料，生物可降解镁基材料在颅颌面外科显示出广阔的应用前景。与传统骨植入材料相比，镁具有良好的降解特性、生物相容性、力学特性和成骨特性，其降解产物镁离子具有抗凋亡、抗炎的作用，能够促进骨折和骨缺损部位的愈合。多项研究将生物可降解镁基材料应用于颅颌面部骨内固定、引导骨再生技术、骨替代材料、药物负载、种植体表面涂层等领域，其结果显示该类材料能够为骨愈合提供稳定的支持，并发挥出良好的促进成骨作用。此外，镁在口腔其他领域，如牙组织工程、促进软组织愈合等方面也表现出应用潜能，显示出生物可降解镁基材料具有重要的研究价值。

关键词: 生物可降解镁基材料, 骨内固定, 引导骨再生技术, 骨替代材料, 药物负载, 镁涂层

Abstract:

As a new generation of bone-implant materials, biodegradable magnesium-based materials show potential application in craniomaxillofacial surgery. Compared with traditional bone-implant materials, magnesium-based materials have excellent degradability, biocompatibility, mechanical properties, and osteogenic-promoting ability. The degradation of Mg implants leads to the production of magnesium ions, which have antiapoptosis and anti-inflammatory functions. Magnesium ions can also promote the healing of fractures and bone defects. Many studies have applied biodegradable magnesium-based materials to the internal fixation of craniomaxillofacial fractures, bone-substitute applications, guided bone regeneration, drug delivery, and implant surface coating. Results reveal that this kind of materials can provide stable support for bone healing and play a suitable role in osteogenic promoting. Magnesium-based materials also demonstrate potential in other fields, such as dental-tissue engineering and promotion of soft-tissue healing. All these findings indicate the importance of magnesium-based materials.

Key words: biodegradable magnesium-based material, internal fixation, guided bone regeneration, bone substitutes, drug delivery system, magnesium coating

中图分类号:

R782.2

常欣楠,刘磊. 生物可降解镁基材料在颅颌面外科的应用及其研究进展[J]. 国际口腔医学杂志, 2024, 51(1): 107-115.

Chang Xinnan,Liu Lei. Applications and research progress of biodegradable magnesium-based materials in craniomaxillofacial surgery[J]. Int J Stomatol, 2024, 51(1): 107-115.

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