国际口腔医学杂志 ›› 2024, Vol. 51 ›› Issue (1): 107-115.doi: 10.7518/gjkq.2024004

• 综述 • 上一篇    下一篇

生物可降解镁基材料在颅颌面外科的应用及其研究进展

常欣楠(),刘磊()   

  1. 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心四川大学华西口腔医院创伤整形外科 成都 610041
  • 收稿日期:2023-03-02 修回日期:2023-08-01 出版日期:2024-01-01 发布日期:2024-01-10
  • 通讯作者: 刘磊
  • 作者简介:常欣楠,硕士,Email:cxn990407@163.com
  • 基金资助:
    四川省科技计划应用基础研究项目(2020YJ0278)

Applications and research progress of biodegradable magnesium-based materials in craniomaxillofacial surgery

Chang Xinnan(),Liu Lei()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Trauma and Orthopedic Wards, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2023-03-02 Revised:2023-08-01 Online:2024-01-01 Published:2024-01-10
  • Contact: Lei Liu
  • Supported by:
    Applied Basic Research Project of Sichuan Provincial Science and Technology Program(2020YJ0278)

摘要:

作为一种新型骨植入材料,生物可降解镁基材料在颅颌面外科显示出广阔的应用前景。与传统骨植入材料相比,镁具有良好的降解特性、生物相容性、力学特性和成骨特性,其降解产物镁离子具有抗凋亡、抗炎的作用,能够促进骨折和骨缺损部位的愈合。多项研究将生物可降解镁基材料应用于颅颌面部骨内固定、引导骨再生技术、骨替代材料、药物负载、种植体表面涂层等领域,其结果显示该类材料能够为骨愈合提供稳定的支持,并发挥出良好的促进成骨作用。此外,镁在口腔其他领域,如牙组织工程、促进软组织愈合等方面也表现出应用潜能,显示出生物可降解镁基材料具有重要的研究价值。

关键词: 生物可降解镁基材料, 骨内固定, 引导骨再生技术, 骨替代材料, 药物负载, 镁涂层

Abstract:

As a new generation of bone-implant materials, biodegradable magnesium-based materials show potential application in craniomaxillofacial surgery. Compared with traditional bone-implant materials, magnesium-based materials have excellent degradability, biocompatibility, mechanical properties, and osteogenic-promoting ability. The degradation of Mg implants leads to the production of magnesium ions, which have antiapoptosis and anti-inflammatory functions. Magnesium ions can also promote the healing of fractures and bone defects. Many studies have applied biodegradable magnesium-based materials to the internal fixation of craniomaxillofacial fractures, bone-substitute applications, guided bone regeneration, drug delivery, and implant surface coating. Results reveal that this kind of materials can provide stable support for bone healing and play a suitable role in osteogenic promoting. Magnesium-based materials also demonstrate potential in other fields, such as dental-tissue engineering and promotion of soft-tissue healing. All these findings indicate the importance of magnesium-based materials.

Key words: biodegradable magnesium-based material, internal fixation, guided bone regeneration, bone substitutes, drug delivery system, magnesium coating

中图分类号: 

  • R782.2
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