Table of Content

    01 September 2018, Volume 45 Issue 5 Previous Issue    Next Issue
    Expert Forum
    Etiology and treatment progress of bruxism
    Qingbin Zhang, Lecheng. Tan
    Inter J Stomatol. 2018, 45 (5):  497-500.  DOI: 10.7518/gjkq.2018.05.001
    Abstract ( 1345 )   HTML ( 90 )   PDF(pc) (3138KB) ( 1880 )   Save

    Bruxism is a common oral parafunctional activity. It is generally defined as the activity of grinding or gnashing of the teeth at times other than during the mastification. Long-term bruxism can lead to abnormal wearing of teeth, and severe wearing can lead to dental hypersensitivity, periodontitis, tooth decay, and pulpitis. Because of larger occlusal force, the temporomandibular joint bears an excessive load, which often results in temporomandibular joint disorders. Due to excessive force, patients suffering from bruxism often complain of masticatory muscle fatigue, tenderness, dysfunction, and myalgia. Pain is commonly seen in masseter muscles, exoskeleton muscles, and digastric muscles, sometimes masseter muscle hypertrophy, and even myalgia of the neck and back. Some people even have autonomic nervous system symptoms and headaches in the morning. This article mainly introduces the common causes of bruxism and progress of treatment methods, so that more dentists can correctly understand the disease, master the treatment and prognosis, thus to better provide effective treatment for patients.

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    Young Experts’ Views
    The treatment strategy of periodontal disease during pregnancy
    Changchang Ye, Lei Zhao, Dongqing Wang, Xiaoli Wang, Haiyan Wang, Meng You, Ping Huang, Yafei Wu
    Inter J Stomatol. 2018, 45 (5):  501-508.  DOI: 10.7518/gjkq.2018.05.002
    Abstract ( 1059 )   HTML ( 48 )   PDF(pc) (1904KB) ( 988 )   Save

    Periodontal disease was a risk factor for adverse pregnancy outcomes. Periodontal treatment during pregnancy will benefit for controlling local and systemic inflammation, even prevent the incidence of adverse pregnancy outcomes. This article reviews the causes, treatment principles and precautions of periodontal disease during pregnancy, hoping to provide some new clinical ideas for the diagnosis and treatment of periodontal diseases during pregnancy.

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    Research progress on calcitonin gene-related peptide on peripheral nerve, vascular regeneration and osseointegra-tion around implants
    Lin Xiang,Huilu Chen,Ying Yuan,Qin Zhang,Na Xin,Ping. Gong
    Inter J Stomatol. 2018, 45 (5):  509-515.  DOI: 10.7518/gjkq.2018.05.003
    Abstract ( 1057 )   HTML ( 7 )   PDF(pc) (1504KB) ( 296 )   Save

    Calcitonin gene-related peptide (CGRP) is a class of biologically active neuropeptide substances mainly released by the sensory nerve. In recent years, the role of CGRP in osseointeration around implants has received wide attention: CGRP positive nerve fibers are present in the bone tissue around the implant; CGRP is associated with the distribution of the capillary vessels around the implant, which suggests that CGRP may have a link with local revascularization on the base of microcirculation. In addition, CGRP could promote the peripheral nerve regeneration, and CGRP positive nerve fibers show regular changes in implant circumference. This paper will make a review of the research progress of CGRP on peripheral nerve, vascular regeneration and osseointegration around implants.

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    Research progress on oral implant materials with antimicrobial properties
    Mengqi Liu,Kuo Gai,Li Jiang
    Inter J Stomatol. 2018, 45 (5):  516-521.  DOI: 10.7518/gjkq.2018.05.004
    Abstract ( 906 )   HTML ( 40 )   PDF(pc) (1164KB) ( 555 )   Save

    Dental implants have attracted widespread attention because of their many advantages, which include comfort, beauty, stability, reliability, and no damage to adjacent teeth. However, unlike natural teeth, dental implants usually present weak resistance to bacterial infection due to their lack of a complete immune defense system. Peri-implantitis is one of the major causes of implant failure. To decrease the incidence of oral implant-related infection and complications, enhancing the antibacterial properties of the implants is important. This paper reviews the research status of dental implant materials with antibacterial properties. It summarizes the characteristics and antibacterial effects of various methods from the aspects of material composition, surface modification, and antibacterial coating. This work seeks to provide a reference for future research and the clinical applications of oral implant materials with antibacterial properties.

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    Research progress on enamel matrix derivative in dental implantation
    Mengmeng Mi,Haibin Xia,Min. Wang
    Inter J Stomatol. 2018, 45 (5):  522-526.  DOI: 10.7518/gjkq.2018.05.005
    Abstract ( 1035 )   HTML ( 14 )   PDF(pc) (1133KB) ( 291 )   Save

    Enamel matrix derivative comes from enamel matrix proteins, which are extracted from young pig tooth germ. The derivative can promote regeneration of periodontal tissues, bone induction, and biomineralization. At present, enamel matrix derivative is mainly used to treat periodontal diseases by promoting regeneration of new cementum, insertion of new functionally oriented periodontal ligament fibers, and formation of new alveolar bone. When used in dental implantation, enamel matrix derivative can promote osseointegration of bone-implant interfaces, repair of bone defects in implants, and healing of soft tissue around implants. As dental implantation is applied in increasingly wider settings, this article offers an overview of the use of enamel matrix derivative in dental implantation.

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    Effects of titanium implant surface topographies on osteogenesis
    Xingying Qi,Guoying Zheng,Lei. Sui
    Inter J Stomatol. 2018, 45 (5):  527-533.  DOI: 10.7518/gjkq.2018.05.006
    Abstract ( 1008 )   HTML ( 14 )   PDF(pc) (1150KB) ( 465 )   Save

    The surface topography of titanium implants is one of the most important factors affecting implant-bone integration. At present, several methods, such as microtopography, nanotopography, and hierarchical hybrid microtopography/nanotopography, have been applied to modify titanium implant surfaces. These techniques promote implant osseointegration more extensively compared with smooth surfaces without modifications. The present study reviews different titanium implant surfaces, including their characteristics, modification methods, and effects on the adhesion, proliferation, and differentiation of osteoblasts. This work provides a reference for optimizing surface designs and achieving early osseointegration.

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    Original Articles
    Effect of individual oral health education on the oral hygiene status of adolescents with invisible aligners
    Zhengjian Ke,Shiyan Huang,Shuhao Xu,Xiaobing Li
    Inter J Stomatol. 2018, 45 (5):  534-538.  DOI: 10.7518/gjkq.2018.05.007
    Abstract ( 745 )   HTML ( 7 )   PDF(pc) (1087KB) ( 154 )   Save

    Objective To reveal the oral hygiene status of adolescents with invisible appliances, identify the importance of individual health education, and provide a theoretical basis for clinical practice. Methods Sixty adolescent patients with invisible appliances were divided into two groups according to health education mode. Twenty adolescents without any orthodontic treatment were enrolled to the blank group. Plaque index (PLI) and bleeding index (BI) were used to describe the status of oral hygiene before, 1 month after, and 6 months after treatment. Results Before treatment, the highest PLI was recorded in the right maxillary first molar of all groups, and the lowest PLI was observed in the left maxillary central incisor. After treatment, the PLI of the experimental group significantly decreased while that of the control group showed no significant change. The BI in the experimental group did not change, but an increase in this index was observed in the control group. Both PLI and BI tended to decrease in the blank group. At the same check-points, statistical differences in terms of PLI and BI were observed between the experimental and control or blank groups.Conclusion Intensified individual oral health education can improve the oral hygiene status of adolescents with invisible appliances.

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    Preparation of graphene oxide coatings on titanium alloy surface
    Xueyang Deng,Lanlan Pan,Ting Hu,Wenhua Li,Xuerong. Xiang
    Inter J Stomatol. 2018, 45 (5):  539-545.  DOI: 10.7518/gjkq.2018.05.008
    Abstract ( 1089 )   HTML ( 11 )   PDF(pc) (3413KB) ( 182 )   Save

    Objective To prepare a kind of coating on the titanium alloy surface with graphene oxide (GO) and to evaluate its biocompatibility preliminarily. Methods Ti substrates prepared by the alkali-hydrothermal reaction were coated with GO (Ti/GO) through layer-by-layer assembly of positively (GO-NH3 +) and negatively (GO-COO -) charged GO sheet with fifteen bilayers. The hydrophobic nature of GO coating on Ti substrates was analyzed by contact angle meter, and the microstructure of GO coating on Ti substrates were characterized by scanning electron microscope (SEM) and atomic force microscope (AFM). The in vitro cellular response was observed by the biological behaviors of bone marrow mesenchymal stem cells (BMSCs) which were inoculated on Ti substrates by SEM and fluorescence microscopy. Porphyromonas gingivalis was utilized to test the antibacterial effect of the Ti/GO surface. Results The GO coating with nano-scale surface topography on the aikali-hydrothermal reacted Ti alloy discs which was hydrophilic was prepared. The GO coating improved the adhension of BMSCs and kept cells live. 86.34% of bacteria had been killed on the Ti/GO surface. Conclusion The GO-coated Ti discs had good biocompatibility and antibacterial property.

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    Application of liquorice and its extract to the prevention and treatment of oral infections and associated diseases
    Jing Wang,Yan Wang,Chuandong Wang,Ruijie Huang,Yan Tian,Wei Hu,Jing Zou
    Inter J Stomatol. 2018, 45 (5):  546-552.  DOI: 10.7518/gjkq.2018.05.009
    Abstract ( 1218 )   HTML ( 28 )   PDF(pc) (1381KB) ( 715 )   Save

    As one of the most ancient and widely used traditional Chinese herbal remedy, liquorice (root, rhizome and stolon of Glycyrrhiza species) shows definite curative effect on many diseases. Such effect has been further proved and confirmed by the research and practice of modern medicine and pharmacology. The major active components of liquorice are commonly identified as liquorice flavonoids, triterpene saponins and polysaccharides. These components are responsible for the phar-macological activities of this herbal remedy, e.g. anti-inflammation, anti-infection, anti-ulcer and antitumor effects. Licorice has numerous beneficial effects on oral infections and associated diseases, according to the results of previous studies. This paper reviews the application of liquorice and its extract to the prevention and treatment of dental caries, periodontitis, oral ulcers and candidiasis. Moreover, the medication safety of liquorice-related products is also discussed.

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    Role of transforming growth factor-β in periodontitis
    Jiangxue Tian,Longyi Mo,Xiaoyue Jia,Chengcheng Liu,Xin. Xu
    Inter J Stomatol. 2018, 45 (5):  553-559.  DOI: 10.7518/gjkq.2018.05.010
    Abstract ( 941 )   HTML ( 12 )   PDF(pc) (1227KB) ( 231 )   Save

    Growth factor is the basic regulator of tissue repair and plays an important role in periodontal tissue regeneration. Transforming growth factor-β (TGF-β) is a peptide that can regulate cell growth and differentiation. TGF-β has played an important role in the occurrence and development of periodontitis in previous studies. Thus, regulation of TGF-β expression may alleviate the symptoms of periodontitis and promote the regeneration of periodontal tissue, which might provide new ideas for the treatment of periodontitis. Research progress in this field is reviewed in the paper.

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    Regulation of programmed death receptor-1 and its ligand signalling pathway and its progress in the treatment of head and neck squamous cell carcinoma
    Lu Mao,Houyu Ju,Guoxin Ren
    Inter J Stomatol. 2018, 45 (5):  560-565.  DOI: 10.7518/gjkq.2018.05.011
    Abstract ( 964 )   HTML ( 9 )   PDF(pc) (1147KB) ( 255 )   Save

    Tumours are closely related to the immune system, and they can escape immune surveillance by stimulating immune inhibitory receptors, which can be blocked by the inhibitory receptors on the T cell. A potential strategy for anti-tumour immune therapy can be developed based on the abovementioned fact. Programmed death receptor-1 (PD-1)/programmed death-ligand 1 (PD-L1) is a newly identified negative co-stimulatory pathway that promotes immune escape. This review discusses the biological characteristics and functions of PD-1/PD-L1, as well as the application of PD-1/PD-L1 antibody in tumour therapy.

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    Progress on the application of fluorescent carbon dots to bacterial imaging and antibiosis
    Yang Meng,Liuran Wang,Qiuling Tang,Xiaohan Ding,Yiyun Yue,Dongning Liu,Weixian Yu
    Inter J Stomatol. 2018, 45 (5):  566-570.  DOI: 10.7518/gjkq.2018.05.012
    Abstract ( 1077 )   HTML ( 7 )   PDF(pc) (1132KB) ( 1506 )   Save

    The fluorescent carbon dots is a new type of nano material consisting of carbon. Their diameter is less than 10 nm. With their excellent fluorescence properties, biocompatibility and surface functionalization, the fluorescent carbon dots has potential for application to the biomedical and antibacterial fields. In recent years, the fluorescent carbon dots become the focus of research in the field of Stomatology. In this article, the characteristics of fluorescent carbon dots and their applications to bacterial imaging and antibacterial field are revieweds.

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    Prevention and treatment for periodontitis by phytoestrogens
    Yixuan Jiang,Longyi Mo,Xiaoyue Jia,Xin Xu,Chengcheng Liu
    Inter J Stomatol. 2018, 45 (5):  571-578.  DOI: 10.7518/gjkq.2018.05.013
    Abstract ( 870 )   HTML ( 14 )   PDF(pc) (1185KB) ( 210 )   Save

    Estrogen metabolism disorder is the systemic promoting factor of periodontitis. Application of estrogen replacement treatment can increase the alveolar bone mass and delay the progression of periodontal disease. However, its biosafety is difficult to assess. Phytoestrogens are natural plant compounds that are similar to estrogen, including soy isoflavones, coumarins and lignans, etc. They have estrogen-like activity by binding with estrogen receptor. Recently, increasing evidence have been found indicating exogenous phytoestrogens could relieve periodontal inflammation and tissue destruction. They offer a promising therapy for periodontitis. Thus, we colligate correlated documents and write the review.

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    Effect and mechanism of diabetes on saliva secretion and salivary glands
    Wei Li,Xiaolin. Nong
    Inter J Stomatol. 2018, 45 (5):  579-583.  DOI: 10.7518/gjkq.2018.05.014
    Abstract ( 1658 )   HTML ( 24 )   PDF(pc) (1132KB) ( 1023 )   Save

    Diabetes and its complications can greatly reduce the quality of life of patients, dry mouth and more water intake is one of the main symptoms of diabetes. Saliva decrements and salivary glands changes may be important causes of diabetic patients to drink more, but also one of the risk factors for other oral problems. Studying the effection mechanism of diabetes on salivary secretion and salivary glands will be important for preventing and curing patients’ symptoms of thirst, maintaining oral health and improving their quality of life. This article reviews the effect of diabetes on saliva secretion and salivary glands and its mechanism.

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    Therapeutic progress of chronic mucocutaneous candidiasis disease
    Lu Feng,Wenxia. Meng
    Inter J Stomatol. 2018, 45 (5):  584-589.  DOI: 10.7518/gjkq.2018.05.015
    Abstract ( 825 )   HTML ( 8 )   PDF(pc) (1166KB) ( 335 )   Save

    Chronic mucocutaneous candidiasis disease (CMCD) is a special type of Candida albicans infection, which is identified associated with immunodeficiency. The pathogenesis is complex and the treatment is more difficult. Conventional antifungal drugs have failed to meet the clinical demands. With the development of various treatment studies expanding, new molecular agents have shown great potential for the treatment of CMCD. This review summarizes the current status of treatment and future development of CMCD, in order to provide more information for clinicians.

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    Lingual nerve injury in the tooth extraction
    Yuhao Wang, Dianri Wang, Jian. Pan
    Inter J Stomatol. 2018, 45 (5):  590-596.  DOI: 10.7518/gjkq.2018.05.016
    Abstract ( 2335 )   HTML ( 68 )   PDF(pc) (1076KB) ( 1787 )   Save

    Nerve injury is one of the most serious complications in the tooth extraction, and it also appears varying degrees of neurological symptoms in the clinical practice. Lingual nerve injury is the most serious type of this complication. In recent years, there have been an increasing number of reports on such complications. Lingual nerve injury can lead to temporary or permanent side of the ipsilateral 2/3 of the tongue numbness and sensory disturbances. There is a variety of treatment for this complication at present but none of these treatments can ensure that every patient will recover completely. So it is important for us to do the preventing work well. This paper will discuss the epidemiology, risk factors, clinical manifestations, diagnosis and treatment of nerve injury in the tooth extraction. We hope that it will help our doctors in the daily work.

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    Long non-coding RNA associated with p53 and the relationship with tumor
    Tongtong Han,Qiaoer Chen,Youming. Zhu
    Inter J Stomatol. 2018, 45 (5):  597-602.  DOI: 10.7518/gjkq.2018.05.017
    Abstract ( 690 )   HTML ( 9 )   PDF(pc) (1197KB) ( 111 )   Save

    p53 gene is a negative regulator of cell growth which can suppress the tumor through the regulation of cell proliferation and apoptosis under normal circumstances. The mutation of p53 often lead to the tumorigenesis. Recently, Long non-coding RNA (lncRNA) was identified as having a function role in the tumorigenesis and development of a variety of tumors. The review aimed to discuss the relationship of LncRNA which associated with p53 and oral cancer, and provide new strategies for patients with oral cancer.

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    Research progress on the repair of alveolar cleft with bone tissue engineering scaffolds
    Fang Yi,Siren Wang,Yanhao Chu,Yanqin. Lu
    Inter J Stomatol. 2018, 45 (5):  603-610.  DOI: 10.7518/gjkq.2018.05.018
    Abstract ( 1303 )   HTML ( 8 )   PDF(pc) (1157KB) ( 160 )   Save

    Alveolar cleft is a common craniofacial abnormality. Traditional treatments, including autogenous bone grafting, suffer from limited bone resources and high incidence of post-operative complications. These problems can be solved by bone tissue engineering, which offers a superior approach to repair the alveolar cleft. This article reviews the progress of using various scaffolds for repairing alveolar cleft.

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    Research progress on anatomy and clinical applications of mandibular nerve communication
    Chaoning Zhan,Liling Zou,Zhao Yuan,Shanli He,Jun Ouyang,Jingxing Dai
    Inter J Stomatol. 2018, 45 (5):  611-614.  DOI: 10.7518/gjkq.2018.05.019
    Abstract ( 954 )   HTML ( 22 )   PDF(pc) (1050KB) ( 409 )   Save

    In recent years, numerous domestic and foreign researchers have reported on nervous communication between branches of the mandibular nerve. Communication was documented between the lingual and mylohyoid nerves, inferior alveolar and lingual nerves, inferior alveolar and auriculotemporal nerves, or inferior alveolar and lateral pterygoid nerves. In addition, the mandibular nerve possibly communicates with other nerves. This article reviews the related issues of mandibular nerve communication to guide clinical operations and promote relevant research.

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    Current research and application situation of robot in stomatology
    Qin Wu,Yimin Zhao
    Inter J Stomatol. 2018, 45 (5):  615-620.  DOI: 10.7518/gjkq.2018.05.020
    Abstract ( 1039 )   HTML ( 24 )   PDF(pc) (1073KB) ( 511 )   Save

    The successful application of medical robots in clinical medicine has led scholars to develop dental robots. Dental robots are expected to break the traditional oral treatment pattern and promote a new technological revolution of stomatology. This article reviews the research and application of robots in the field of stomatology.

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