Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (5): 501-508.doi: 10.7518/gjkq.2018.05.002

• Young Experts’ Views • Previous Articles     Next Articles

The treatment strategy of periodontal disease during pregnancy

Changchang Ye1(),Lei Zhao1,Dongqing Wang2,Xiaoli Wang3,Haiyan Wang4,Meng You5,Ping Huang1,Yafei Wu1   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2. Dept. of Periodontology, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China
    3. Dept. of Gynaecology and Obstetrics, West China Women’s and Children’s Hospital, Sichuan University, Chengdu 610041, China
    4. Dept. of Oral Medicine, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China
    5. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Radiology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-01-22 Revised:2018-06-07 Online:2018-09-01 Published:2018-09-20
  • Contact: Changchang Ye
  • Supported by:
    This study was supported by National Natural and Science Foundation of China(81600875);Chengdu Science and Technology Bureau(2015-HM01-00088-SF);National key clinical specialist construction programs of China (2010)


Periodontal disease was a risk factor for adverse pregnancy outcomes. Periodontal treatment during pregnancy will benefit for controlling local and systemic inflammation, even prevent the incidence of adverse pregnancy outcomes. This article reviews the causes, treatment principles and precautions of periodontal disease during pregnancy, hoping to provide some new clinical ideas for the diagnosis and treatment of periodontal diseases during pregnancy.

Key words: periodontal disease, adverse pregnancy outcomes, drugs in pregnancy, periodontal treatment

CLC Number: 

  • R781.4


Fig 1

The possible mechanism of how periodontal disease affect pregnancy outcomes"

Fig 2

Treatment of a gingivitis during pregnancy"

Fig 3

An epulis during pregnancy resected by using Nd-YAG Laser"

Tab 1

Drugs and their U.S. FDA classification of oral treatment"

药物 分级 使用提示
维生素类、枸橼酸类 A:动物实验和临床观察未见对胎儿有损害,是最安全的一类。 可安全使用
青霉素类、部分头孢类、对乙酰氨基酚、甲硝唑、利多卡因 B:动物实验中显示对胎仔有危害,但临床研究未能证实,或动物实验未发现有致畸作用,但无临床验证资料。 有明确指征时慎用
氧氟沙星、阿司匹林、阿替卡因 C:仅在动物研究中证实对胎仔有致畸作用或者杀胚胎作用,但人类研究缺乏资料证实。 在确有应用指征时,充分权衡利弊后决定是否选用
米诺环素、卡马西平、碘制剂 D:临床有一定资料表明对胎儿有危害的迹象,但治疗孕妇疾病的疗效肯定,又无代替之药物,其效益明显超过其危害时,再考虑使用。 避免使用,但在确有应用指征,且患者受益大于风险时选用
利巴韦林 X:动物或人的研究中已证实对胎儿有危害,为妊娠期禁用的药物。 禁用

Fig 4

The ideal strategy for pregnant patients visit dental clinic"

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