Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (5): 509-515.doi: 10.7518/gjkq.2018.05.003

• Young Experts’ Views • Previous Articles     Next Articles

Research progress on calcitonin gene-related peptide on peripheral nerve, vascular regeneration and osseointegra-tion around implants

Lin Xiang,Huilu Chen,Ying Yuan,Qin Zhang,Na Xin,Ping. Gong()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-02-12 Revised:2018-06-09 Online:2018-09-01 Published:2018-09-20
  • Contact: Ping. Gong E-mail:dentistgong@hotmail.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81701007);Sichuan Science and Technology Program(2018RZ0087);the Fundamental Research Funds for the Central Universities(2017SCU12056);the Fundamental Research Funds for the Central Universities(2018SCUH0006);Project funded by China Postdoctoral Science Foundation(2018M631091);Youth Science Foundation of West China Hospital of Stomatology of Sichuan University(2016-11)

RichHTML

10

PDF (PC)

578

Abstract:

Calcitonin gene-related peptide (CGRP) is a class of biologically active neuropeptide substances mainly released by the sensory nerve. In recent years, the role of CGRP in osseointeration around implants has received wide attention: CGRP positive nerve fibers are present in the bone tissue around the implant; CGRP is associated with the distribution of the capillary vessels around the implant, which suggests that CGRP may have a link with local revascularization on the base of microcirculation. In addition, CGRP could promote the peripheral nerve regeneration, and CGRP positive nerve fibers show regular changes in implant circumference. This paper will make a review of the research progress of CGRP on peripheral nerve, vascular regeneration and osseointegration around implants.

Key words: dental implant, calcitonin gene-related peptide, osseointegration, microcirculation, peripheral nerve

CLC Number: 

  • R783.6

TrendMD: 
[1] Amara SG, Jonas V, Rosenfeld MG , et al. Alter-native RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products[J]. Nature, 1982,298(5871):240-244.
doi: 10.1038/298240a0
[2] Burns LE, Ramsey AA, Emrick JJ , et al. Variability in capsaicin-stimulated calcitonin gene-related peptide release from human dental pulp[J]. J Endod, 2016,42(4):542-546.
doi: 10.1016/j.joen.2015.12.010
[3] Hu R, Li YJ, Li XH , An overview of non-neural sources of calcitonin gene-related peptide[J]. Curr Med Chem, 2016,23(8):763-773.
doi: 10.2174/0929867323666160210125416
[4] Assas BM, Pennock JI, Miyan JA , Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis[J]. Front Neurosci, 2014,8:23.
doi: 10.3389/fnins.2014.00023 pmid: 24592205
[5] Lerner UH , Deletions of genes encoding calcitonin/alpha-CGRP, amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors and calcitonin receptor-like receptors in bone[J]. J Musculoskelet Neuronal In-teract, 2006,6(1):87-95.
[6] Poyner DR, Sexton PM, Marshall I , et al. International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors[J]. Pharmacol Rev, 2002,54(2):233-246.
doi: 10.1124/pr.54.2.233
[7] González-Hernández A, Marichal-Cancino BA , Lo-zano-Cuenca J, et al. Heteroreceptors modulating CGRP release at neurovascular junction: potential therapeutic implications on some vascular-related diseases[J]. Biomed Res Int, 2016,2016:2056786.
[8] Russell FA, King R, Smillie SJ , et al. Calcitonin gene- related peptide: physiology and pathophysiology[J]. Physiol Rev, 2014,94(4):1099-1142.
doi: 10.1152/physrev.00034.2013 pmid: 25287861
[9] Bo Y, Yan L, Gang Z , et al. Effect of calcitonin gene- related peptide on osteoblast differentiation in an osteoblast and endothelial cell co-culture system[J]. Cell Biol Int, 2012,36(10):909-915.
doi: 10.1042/CBI20110562
[10] He H, Chai J, Zhang S , et al. CGRP may regulate bone metabolism through stimulating osteoblast differen-tiation and inhibiting osteoclast formation[J]. Mol Med Rep, 2016,13(5):3977-3984.
doi: 10.3892/mmr.2016.5023
[11] Fang Z, Yang Q, Xiong W , et al. Effect of CGRP-adenoviral vector transduction on the osteoblastic differentiation of rat adipose-derived stem cells[J]. PLoS One, 2013,8(8):e72738.
doi: 10.1371/journal.pone.0072738
[12] Yoo YM, Kwag JH, Kim KH , et al. Effects of neuro-peptides and mechanical loading on bone cell resorp-tion in vitro[J]. Int J Mol Sci, 2014,15(4):5874-5883.
doi: 10.3390/ijms15045874 pmid: 4013601
[13] Kauther MD, Neuerburg C, Wefelnberg F , et al. RANKL-associated suppression of particle-induced osteolysis in an aged model of Calcitonin and α- CGRP deficiency[J]. Biomaterials, 2013,34(12):2911-2919.
doi: 10.1016/j.biomaterials.2013.01.034
[14] Notoya M, Arai R, Katafuchi T , et al. A novel mem-ber of the calcitonin gene-related peptide family, calcitonin receptor-stimulating peptide, inhibits the formation and activity of osteoclasts[J]. Eur J Phar-macol, 2007,560(2/3):234-239.
doi: 10.1016/j.ejphar.2007.01.034
[15] Kawase T, Okuda K, Burns DM , Immature human osteoblastic MG63 cells predominantly express a subtype 1-like CGRP receptor that inactivates extra-cellular signal response kinase by a cAMP-dependent mechanism[J]. Eur J Pharmacol, 2003,470(3):125-137.
doi: 10.1016/S0014-2999(03)01763-1
[16] Villa I, Melzi R, Pagani F , et al. Effects of calcitonin gene-related peptide and amylin on human osteoblast- like cells proliferation[J]. Eur J Pharmacol, 2000,409(3):273-278.
doi: 10.1016/S0014-2999(00)00872-4
[17] 徐格, 吴雪晖, 许建中 , 等. 人骨髓间充质干细胞表面CGRP受体存在的研究[J]. 华南国防医学杂志, 2008,22(2):15-17.
Xu G, Wu XH, Xu JZ , et al. Research for evidence of CGRP receptor existence in human mesenchymal stem cells[J]. Milit Med J South Chin, 2008,22(2):15-17.
[18] Zhou R, Yuan Z, Liu J , et al. Calcitonin gene-related peptide promotes the expression of osteoblastic genes and activates the WNT signal transduction pathway in bone marrow stromal stem cells[J]. Mol Med Rep, 2016,13(6):4689-4696.
doi: 10.3892/mmr.2016.5117
[19] Liu Y, Zheng G, Liu L , et al. Inhibition of osteogene-sis surrounding the titanium implant by CGRP defi-ciency[J]. Connect Tissue Res, 2018,59(2):147-156.
doi: 10.1080/03008207.2017.1317759
[20] Zhang Y, Xu J, Ruan YC , et al. Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats[J]. Nat Med, 2016,22(10):1160-1169.
doi: 10.1038/nm.4162
[21] Kajiwara N, Masaki C, Mukaibo T , et al. Soft tissue biological response to zirconia and metal implant abutments compared with natural tooth: microcircu-lation monitoring as a novel bioindicator[J]. Implant Dent, 2015,24(1):37-41.
[22] Nakamoto T, Kanao M, Kondo Y , et al. Two-dimen-sional real-time blood flow and temperature of soft tissue around maxillary anterior implants[J]. Implant Dent, 2012,21(6):522-527.
doi: 10.1097/ID.0b013e318272fe81
[23] Fiorellini JP, Chen PK, Nevins M , et al. A retrospec-tive study of dental implants in diabetic patients[J]. Int J Periodont Restor Dent, 2000,20(4):366-373.
[24] 王洪亮, 安斯耀, 焦铁军 , 等. 脂肪干细胞对糖尿病兔种植体周围植骨及骨结合影响的实验研究[J]. 牙体牙髓牙周病学杂志, 2013,23(5):298-302, 309.
doi: 10.7666/d.D357912
Wang HL, An SY, Jiao TJ , et al. Effects of adipose-derived stem cells on bone formation and osseointe-gration of implant in diabetic rabbits[J]. Chin J Con-serv Dent, 2013,23(5):298-302, 309.
doi: 10.7666/d.D357912
[25] Ye F, Deng PY, Li D , et al. Involvement of endothe-lial cell-derived CGRP in heat stress-induced protec-tion of endothelial function[J]. Vascul Pharmacol, 2007,46(4):238-246.
doi: 10.1016/j.vph.2006.10.008
[26] Luo D, Zhang YW, Peng WJ , et al. Transient receptor potential vanilloid 1-mediated expression and secre-tion of endothelial cell-derived calcitonin gene-related peptide[J]. Regul Pept, 2008,150(1/2/3):66-72.
doi: 10.1016/j.regpep.2008.05.007
[27] Li YJ, Song QJ, Xiao J , Calcitonin gene-related pep-tide: an endogenous mediator of preconditioning[J]. Acta Pharmacol Sin, 2000,21(10):865-869.
doi: 10.1021/ar9900257 pmid: 11501035
[28] Mai TH, Wu J, Diedrich A , et al. Calcitonin gene-related peptide (CGRP) in autonomic cardiovascular regulation and vascular structure[J]. J Am Soc Hyper- tens, 2014,8(5):286-296.
doi: 10.1016/j.jash.2014.03.001
[29] Smillie SJ, King R, Kodji X , et al. An ongoing role of α-calcitonin gene-related peptide as part of a protective network against hypertension, vascular hypertrophy, and oxidative stress[J]. Hypertension, 2014,63(5):1056-1062.
doi: 10.1161/HYPERTENSIONAHA.113.02517
[30] Meleagros L, Ghatei MA, Bloom SR , Release of va- sodilator, but not vasoconstrictor, neuropeptides and of enteroglucagon by intestinal ischaemia/reper-fusion in the rat[J]. Gut, 1994,35(12):1701-1706.
doi: 10.1136/gut.35.12.1701
[31] Tang ZL, Dai W, Li YJ , et al. Involvement of cap-saicin-sensitive sensory nerves in early and delayed cardioprotection induced by a brief ischaemia of the small intestine[J]. Naunyn Schmiedebergs Arch Phar- macol, 1999,359(3):243-247.
doi: 10.1007/PL00005348
[32] Chim SM, Tickner J, Chow ST , et al. Angiogenic fac- tors in bone local environment[J]. Cytokine Growth Factor Rev, 2013,24(3):297-310.
doi: 10.1016/j.cytogfr.2013.03.008 pmid: 23611723
[33] Tuo Y, Guo X, Zhang X , et al. The biological effects and mechanisms of calcitonin gene-related peptide on human endothelial cell[J]. J Recept Signal Trans-duct Res, 2013,33(2):114-123.
doi: 10.3109/10799893.2013.770528
[34] 王钊, 金丹, 陀泳华 , 等. 降钙素基因相关肽促进大鼠BMSCs迁移及VEGF的表达[J]. 中国修复重建外科杂志, 2011,25(11):1371-1376.
Wang Z, Jin D, Tuo YH , et al. Calcitonin gene-related peptide promoting migration of rat bone marrow me- senchymal stem cells and stimulating expression of vascular endothelial growth factor[J]. Chin J Reparat Reconstr Surg, 2011,25(11):1371-1376.
[35] Bo Y, Yan L, Gang Z , et al. Effect of calcitonin gene-related peptide on osteoblast differentiation in an osteoblast and endothelial cell co-culture system[J]. Cell Biol Int, 2012,36(10):909-915.
doi: 10.1042/CBI20110562
[36] 廉凯, 杜靖远 . 降钙素基因相关肽对鼠成骨细胞IGF-I及IGF-IR mRNA表达的影响[J]. 中国矫形外科杂志, 2001,8(11):1084-1087.
Lian K, Du JY . The effects of calcitonin gene-related peptide on the expression of IGF-I and IGF-IR mRNA in rat osteoblasts[J]. Orthop J Chin, 2001,8(11):1084-1087.
[37] Demulder A, Guns M, Ismail A , et al. Increased os-teoclast-like cells formation in long-term bone marrow cultures from patients with a spinal cord injury[J]. Calcif Tissue Int, 1998,63(5):396-400.
doi: 10.1007/s002239900547
[38] Jiang SD, Jiang LS, Dai LY , Mechanisms of osteopo-rosis in spinal cord injury[J]. Clin Endocrinol (Oxf), 2006,65(5):555-565.
doi: 10.1111/j.1365-2265.2006.02683.x pmid: 17054455
[39] Bjurholm A, Kreicbergs A, Brodin E , et al. Substance P- and CGRP-immunoreactive nerves in bone[J]. Peptides, 1988,9(1):165-171.
doi: 10.1016/0196-9781(88)90023-X pmid: 2452430
[40] van Steenberghe D . From osseointegration to osseo-perception[J]. J Dent Res, 2000,79(11):1833-1837.
doi: 10.1177/00220345000790110301 pmid: 11145351
[41] Klineberg I, Calford MB, Dreher B , et al. A consen-sus statement on osseoperception[J]. Clin Exp Phar-macol Physiol, 2005,32(1/2):145-146.
doi: 10.1111/j.1440-1681.2005.04144.x pmid: 15730451
[42] Lambrichts I , Histological and ultrastructural aspects of bone innervations//Jacobs R. Osseoperception[M]. Leuven: Catholic University Leuven, 1998: 13-20.
[43] Wang YH, Kojo T, Ando H , et al. Nerve regenera-tion after implantation in peri-implant area. A histo-logical study on different implant materials in dogs//Jacobs R. Osseoperception[M]. Leuven: Catholic University Leuven, 1998: 3-11.
[44] Toth CC, Willis D, Twiss JL , et al. Locally syn-thesized calcitonin gene-related peptide has a critical role in peripheral nerve regeneration[J]. J Neuropa-thol Exp Neurol, 2009,68(3):326-337.
doi: 10.1097/NEN.0b013e31819ac71b
[45] Sample SJ, Heaton CM, Behan M , et al. Role of cal-citonin gene-related peptide in functional adaptation of the skeleton[J]. PLoS One, 2014,9(12):e113959.
doi: 10.1371/journal.pone.0113959 pmid: 4275203
[46] Ma L, Xiang L, Yao Y , et al. CGRP-alpha application: a potential treatment to improve osseoperception of endosseous dental implants[J]. Med Hypotheses, 2013,81(2):297-299.
doi: 10.1016/j.mehy.2013.04.025
[1] Han Chong,He Dongning,Yu Feiyan,Wu Dongchao. Research progress on the mechanism and treatment of pain after oral implants [J]. Int J Stomatol, 2024, 51(1): 99-106.
[2] Liao Honglin,Fang Zhonghan,Zhang Yanyan,Liu Fei,Shen Jiefei.. Diagnosis and treatment of post-traumatic trigeminal neuropathic pain after dental implantation [J]. Int J Stomatol, 2023, 50(6): 729-738.
[3] Gong Jiaming,Zhao Ruimin,Pan Hongwei,Lang Xin,Yu Zhanhai,Li Jianxue. Meta-analysis of dynamic navigation versus static navigation in the accuracy of implant surgery [J]. Int J Stomatol, 2023, 50(5): 538-551.
[4] Zhu Keshi,Liao Anqi,Yu Youcheng.. Research progress on the application of machine learning in dental implantology [J]. Int J Stomatol, 2023, 50(4): 491-498.
[5] Lu Qian,Xia Haibin,Wang Min.. Research progress on implantoplasty in the treatment of peri-implantitis [J]. Int J Stomatol, 2023, 50(2): 152-158.
[6] Man Yi, Huang Dingming. Combined treatment strategy of oral implantology and endodontics microsurgery: clinical protocol and practical cases (part 2) [J]. Int J Stomatol, 2022, 49(6): 621-632.
[7] Man Yi, Huang Dingming. Combined treatment strategy of oral implantology and endodontic microsurgery for bone augmentation and en-dodontic diseases in aesthetic area (part 1): application basis and indications [J]. Int J Stomatol, 2022, 49(5): 497-505.
[8] Wang Yue,Wen Bing,Deng Mengting,Li Jianping. Research advances of low-level laser therapy on peri-implant tissue healing [J]. Int J Stomatol, 2021, 48(6): 725-730.
[9] Zhu Xuanzhi,Zhao Lei. Research progress on the relationship between hypothyroidism and periodontitis [J]. Int J Stomatol, 2021, 48(4): 380-384.
[10] Feng Lu,Meng Wenxia. Research progress on the problems of dental implant treatment in patients with common oral mucosal disease [J]. Int J Stomatol, 2021, 48(2): 147-155.
[11] Wang Jia,Li Wenxia,Yin Lihua. Restoration strategy of dental implant for impacted teeth in the edentulous area [J]. Int J Stomatol, 2021, 48(1): 77-81.
[12] Wu Jielin,Gao Ying. Application progress on free soft-tissue grafts harvested from palatal mucosa [J]. Int J Stomatol, 2020, 47(6): 686-692.
[13] Xiao Yuhan,Yu Haiyang. Interproximal open contacts between implant restorations and adjacent teeth [J]. Int J Stomatol, 2020, 47(2): 202-205.
[14] Yu Wanqi,Zhou Yanmin,Zhao Jinghui. Research status of new materials in dental implants [J]. Int J Stomatol, 2019, 46(4): 488-496.
[15] Meijie Wang,Xin Tan,Yuwei Zhao,Haiyang Yu. Influences of immediat implant or traditional implant on postoperative pain [J]. Int J Stomatol, 2019, 46(3): 292-296.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .