Int J Stomatol

Int J Stomatol ›› 2021, Vol. 48 ›› Issue (4): 380-384.doi: 10.7518/gjkq.2021081

• Periodontitis • Previous Articles     Next Articles

Research progress on the relationship between hypothyroidism and periodontitis

Zhu Xuanzhi(),Zhao Lei()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-01-05 Revised:2021-03-27 Online:2021-07-01 Published:2021-06-30
  • Contact: Lei Zhao E-mail:826868536@qq.com;jollyzldoc@163.com
  • Supported by:
    National Natural Science Foundation of China(81970944)

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Abstract:

The thyroid gland regulates various physiological activities by secreting thyroid hormones, and its abnormal function can lead to bone metabolism disorders and osteoporosis. Periodontitis is a chronic inflammatory disease caused by plaque biofilm, and alveolar bone resorption is one of its primary features. Clinical trials and animal experiments indicated that hypothyroidism is positively related to periodontal disease. Hypothyroidism may affect bone metabolism and the expression of immune factors by regulating the activation of downstream hormone receptors, thereby inhibiting alveolar bone osteogenesis and promoting bone resorption. In addition, low-turnover osteoporosis caused by hypothyroidism may be a systemic condition that aggravates the progression of periodontitis. This article reviews the relevance and possible mechanisms of the above two diseases.

Key words: hypothyroidism, bone metabolism, periodontitis, dental implant

CLC Number: 

  • R781.4

TrendMD: 
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