Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (5): 571-578.doi: 10.7518/gjkq.2018.05.013

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Prevention and treatment for periodontitis by phytoestrogens

Yixuan Jiang1,Longyi Mo2,Xiaoyue Jia3,Xin Xu3,Chengcheng Liu4()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
    3. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    4. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-11-04 Revised:2018-04-11 Online:2018-09-01 Published:2018-09-20
  • Contact: Chengcheng Liu E-mail:liuchengcheng519@163.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81600871);This study was supported by National Natural Science Foundation of China(81771099);Scientific Research Foundation of the Science and Technology Department of Sichuan Province(2016JY0006);Scientific Research Foundation of the Science and Technology Department of Sichuan Province(2017029)

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Abstract:

Estrogen metabolism disorder is the systemic promoting factor of periodontitis. Application of estrogen replacement treatment can increase the alveolar bone mass and delay the progression of periodontal disease. However, its biosafety is difficult to assess. Phytoestrogens are natural plant compounds that are similar to estrogen, including soy isoflavones, coumarins and lignans, etc. They have estrogen-like activity by binding with estrogen receptor. Recently, increasing evidence have been found indicating exogenous phytoestrogens could relieve periodontal inflammation and tissue destruction. They offer a promising therapy for periodontitis. Thus, we colligate correlated documents and write the review.

Key words: phytoestrogen, periodontitis, estrogen receptor, alveolar bone, estrogen replacement treatment

CLC Number: 

  • R781.4 +2

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