Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (5): 546-552.doi: 10.7518/gjkq.2018.05.009

• Reviews • Previous Articles     Next Articles

Application of liquorice and its extract to the prevention and treatment of oral infections and associated diseases

Jing Wang1,2,Yan Wang2,Chuandong Wang2,Ruijie Huang3,Yan Tian4,Wei Hu2,Jing Zou3()   

  1. 1. College of Pharmaceutical Science, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
    2. State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, China
    3. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    4. School of Dentistry, University of California, Los Angeles, Los Angeles CA 90095, USA
  • Received:2017-11-14 Revised:2018-05-27 Online:2018-09-01 Published:2018-09-20
  • Contact: Jing Zou
  • Supported by:
    This study was supported by the National Natural Science Foundation of China(81470035);This study was supported by the National Natural Science Foundation of China(31370110);This study was supported by the National Natural Science Foundation of China(31570065);Postdoctoral Science Foundation of China(2016M592177)


As one of the most ancient and widely used traditional Chinese herbal remedy, liquorice (root, rhizome and stolon of Glycyrrhiza species) shows definite curative effect on many diseases. Such effect has been further proved and confirmed by the research and practice of modern medicine and pharmacology. The major active components of liquorice are commonly identified as liquorice flavonoids, triterpene saponins and polysaccharides. These components are responsible for the phar-macological activities of this herbal remedy, e.g. anti-inflammation, anti-infection, anti-ulcer and antitumor effects. Licorice has numerous beneficial effects on oral infections and associated diseases, according to the results of previous studies. This paper reviews the application of liquorice and its extract to the prevention and treatment of dental caries, periodontitis, oral ulcers and candidiasis. Moreover, the medication safety of liquorice-related products is also discussed.

Key words: Glycyrrhiza, dental caries, Streptococcus mutans, periodontal disease, Candida albicans, recurrent aphthous ulcer

CLC Number: 

  • R781


Fig 1

Chemical structure of some active compounds identified in Glycyrrhiza species"

Tab 1

Compounds identified in Glycyrrhiza species with pharmacological activities against oral infections and associated diseases"

结构类别 活性化合物代表 治疗疾病 文献
紫檀烯类 甘草茎醇A 龋病 [6-7]
皂苷类 甘草甜素 龋病 [12]
口腔念珠菌病 [30]
甘草次酸 牙周组织病 [19]
口腔念珠菌病 [29]
芪类 甘草宁 龋病 [7]
牙周组织病 [33]
口腔念珠菌病 [30]
甘草西定 牙周组织病 [18]
甘草异黄烷A 牙周组织病 [18]
查耳酮类 甘草查尔酮A 口腔念珠菌病 [30]
类黄酮类 甘草素 口腔念珠菌病 [31]
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