Int J Stomatol ›› 2022, Vol. 49 ›› Issue (5): 511-520.doi: 10.7518/gjkq.2022050

• Oral Microbiology • Previous Articles     Next Articles

Research progress on drug synergism with fluconazole in fluconazole-resistant Candida albicans

Yang Sirui1,2(),Ren Biao1,Peng Xian1,Xu Xin1,2()   

  1. 1.State Key Laboratory of Oral Diseass & National Clinical Resenrch Center for Oral Di-seases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
    2.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-12-12 Revised:2022-04-15 Online:2022-09-01 Published:2022-09-16
  • Contact: Xin Xu;
  • Supported by:
    National Natural Science Foundation of China(81771099)


Candida albicans is the most common opportunistic pathogen in invasive infections. Azoles, especially fluconazole (FLC) is the most extensively used antifungal drug. However, with the increasingly reported drug resistance, combinatory use of other antifungals that synergize with FLC can reduce the dose and toxicity of both drugs. This strategy represents a promising approach to the management of drug-resistance emergence. This article reviews the common mechanisms of drug resistance developed by Candida albicans and discusses the progress of research on the discovery of drug synergism with FLC to provide reference for the development of novel antifungals.

Key words: Candida albicans, azole-resistant, efflux pump, biofilm

CLC Number: 

  • R 782.2


Fig 1

The common pathway of drug synergism with fluconazole"

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