国际口腔医学杂志

国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (2): 219-224.doi: 10.7518/gjkq.2020011

• 综述 • 上一篇    下一篇

形状记忆高分子材料在骨缺损修复再生领域的研究进展

刘育豪1,张陶2()   

  1. 1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院口腔颌面外科 成都 610041
    2. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院全科门诊 成都 610041
  • 收稿日期:2019-07-05 修回日期:2019-10-25 出版日期:2020-03-01 发布日期:2020-03-12
  • 通讯作者: 张陶
  • 作者简介:刘育豪,学士,Email： 2014181641015@stu.scu.edu.cn
  • 基金资助:
    国家自然科学基金(81800947);中国博士后科学基金(2018M640930);四川大学华西口腔医院青年科学研究基金(WCHS-201706)

Research progress on shape memory polymers in bone defect repair and regeneration

Liu Yuhao1,Zhang Tao2()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of General Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-07-05 Revised:2019-10-25 Online:2020-03-01 Published:2020-03-12
  • Contact: Tao Zhang
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81800947);China Postdoctoral Science Foundation(2018M640930);Youth Science Foundation of West China Hospital of Stomatology, Sichuan University(WCHS-201706)

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摘要：

作为一种新颖的智能响应型生物材料,形状记忆高分子材料（SMP）已用于骨缺损修复研究。该类材料可在温度、水分等外界刺激下发生“初始态”与“临时态”之间的三维形状转变,可紧密充填骨缺损,改善了常规植入材料形状不匹配、植入难度大等缺点。此外,该类材料改性后可作为多孔性骨组织工程支架,用以装载各类生物活性因子及干细胞,促进缺损处新骨形成。SMP已在微创性、修复不规则骨缺损、促进骨缺损再生等方面展现出良好前景。本文对其目前在骨缺损修复中的原理、效应、性能优化等研究进展作一综述。

关键词: 形状记忆, 高分子材料, 骨缺损, 骨组织工程

Abstract:

As novel stimuli-responsive biomaterials, shape memory polymers (SMPs) have been used in bone defect repair. The 3D shape of these biomaterials can be switched between initial and temporary states under external stimuli, such as temperature changes and water contact, making them suitable for tightly filling bone defects and advantageous over traditional materials featuring shape mismatch and complicated implantation. In addition, modified SMPs can be used as porous bone tissue engineering scaffolds to load various bioactive factors and stem cells for new bone formation. Recently, SMPs have shown promising prospects in minimal invasiveness, repairing irregular bone defects, and promoting bone defect regeneration. This review will discuss the current progresses of SMPs in bone tissue engineering, including their mechanism, biological effects, and performance optimization.

Key words: shape memory effect, polymer material, bone defect, bone tissue engineering

中图分类号: 

  • R318.08

图 1

形状记忆效应图示 A：SMP由致密的植入性形态（例如棒状）,向复杂骨缺损形态转化,亦可延展以实现体积的增大或长度/宽度的延长,体现微创优势;B：温敏型形状记忆效应的分子原理。"

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