国际口腔医学杂志

国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (1): 90-94.doi: 10.7518/gjkq.2020002

• 综述 • 上一篇    下一篇

生物活性玻璃/壳聚糖复合材料在生物医学领域的应用

邹俊东,刘定坤,杨楠,王谜,刘志辉()   

  1. 吉林大学口腔医院修复科 长春 130021
  • 收稿日期:2019-04-10 修回日期:2019-09-16 出版日期:2020-01-01 发布日期:2020-01-01
  • 通讯作者: 刘志辉
  • 作者简介:邹俊东,硕士,Email： cyclel@sina.com
  • 基金资助:
    吉林省科学技术厅重点科技研发项目(20180201056YY);吉林省科学技术厅重点科学技术成果转化项目(20180201056YY);长春市科学技术局长春市地院（校，所）合作专项(17DY024)

An overview of bioactive glasses/chitosan composites for biomedical applications

Zou Jundong,Liu Dingkun,Yang Nan,Wang Mi,Liu Zhihui()   

  1. Dept. of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun 130021, China
  • Received:2019-04-10 Revised:2019-09-16 Online:2020-01-01 Published:2020-01-01
  • Contact: Zhihui Liu
  • Supported by:
    This study was supported by Key Science and Technology Research and Development Project of Jilin Science and Technology Department(20180201056YY);Key Science and Technology Achievements Transformation Project of Jilin Provincial Science and Technology Department(20180201056YY);Changchun Science and Technology Bureau Changchun City Campus (School, Institute) Cooperation Special(17DY024)

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摘要：

无机生物活性玻璃（BG）和天然壳聚糖（CS）均具有良好的生物学性能,被广泛应用于生物医学领域。近年研究发现二者组成的复合材料具有更好的机械性能和生物学性能,拥有巨大的发展潜力。本文在大量文献的基础上,简要介绍了BG和CS的物理和化学性质,主要论述了BG/CS复合材料在骨组织工程、药物及生物活性成分缓释和种植体表面修饰方面的应用现状,期望为该复合物的开发应用提供参考。

关键词: 生物活性玻璃, 壳聚糖, 骨组织工程, 缓释, 种植体修饰

Abstract:

Inorganic bioactive glass (BG) and natural chitosan (CS) are applied widely in biomedical fields due to their biological properties. Recent studies showed that compared with individual components, composites have optimised mechanical and biological properties, indicating their enormous potential for future development. This paper briefly introduces the physical and chemical properties of BG and CS and emphasises the recent studies on various applications of the BG/CS composites in bone tissue engineering, controlled release of drugs and molecules and implant dressing based on literature.

Key words: bioactive glass, chitosan, bone tissue engineering, controlled release, implant dressing

中图分类号: 

  • R318.08

表 1

骨密质、骨松质和BG、CS的机械性能比较"

材料类型 压缩强度/MPa 杨氏模量/MPa 孔隙率/%
骨密质 130~200 3 000~30 000 3~12
骨松质 0.1~20.0 20~26 940 50~90
BG（45S5 BG） 14~500 35 000~100 000 30~80
CS 0.005~89.480 35.50~88.98
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