国际口腔医学杂志

国际口腔医学杂志 ›› 2022, Vol. 49 ›› Issue (4): 404-411.doi: 10.7518/gjkq.2022063

• 论著 • 上一篇    下一篇

掺锌生物活性玻璃纳米颗粒对复合树脂力学性能影响的实验研究

王路明1,2(),曹潇1,仵琳悦1,李蕴聪1,雷波3,牛林1()   

  1. 1.西安交通大学陕西省颅颌面精准医学研究重点实验室 西安 710004
    2.西安医学院第二附属医院口腔科 西安 710038
    3.西安交通大学前沿科学技术研究院 西安 710054
  • 收稿日期:2021-12-10 修回日期:2022-03-06 出版日期:2022-07-01 发布日期:2022-06-28
  • 通讯作者: 牛林
  • 作者简介:王路明，主治医师，学士，Email：29968646@qq.com
  • 基金资助:
    陕西省自然科学基金(2020JM-414)

Effect of Zn-doped bioactive glass nanoparticles on the mechanical properties of modified composite resin

Wang Luming1,2(),Cao Xiao1,Wu Linyue1,Li Yuncong1,Lei Bo3,Niu Lin1()   

  1. 1.Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Xi’an Jiaotong University, Xi’an 710004, China
    2.Dept. of Stomatology, The Second Affilia-ted Hospital of Xi’an Medical University, Xi’an 710038, China
    3.Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710054, China
  • Received:2021-12-10 Revised:2022-03-06 Online:2022-07-01 Published:2022-06-28
  • Contact: Lin Niu
  • Supported by:
    National Science Basic Research Plan in Shaanxi Province of China(2020JM-414)

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摘要：

目的 制备具有生物活性的掺锌活性玻璃纳米颗粒（Zn@BGN）并利用其对复合树脂进行改性，研究Zn@BGN对改性复合树脂力学性能的影响。方法 采用溶胶-凝胶模板法制备3种不同掺锌比例的Zn@BGN，通过体外生物活性实验筛选适宜的掺锌比例。将Zn@BGN分别以质量分数为10%、15%、20%的添加比例制备3组改性复合树脂实验组，以未改性复合树脂作为对照组，利用万能材料试验机及显微硬度仪测试挠曲强度（FS）、径向拉伸强度（DTS）、压缩强度和维氏硬度等力学性能。结果 溶胶-凝胶模板法制备的Zn@BGN呈现为较规则的直径约150 nm的球形颗粒，单分散性良好。当Zn@BGN中掺锌质量分数为1.6%时，生物活性良好。3组改性复合树脂实验组中，当Zn@BGN添加质量分数为10%和15%时，与对照组相比，力学性能的差异无统计学意义（P>0.05）；而当Zn@BGN添加质量分数为20%时，FS和DTS明显低于对照组（P<0.05）。结论 溶胶-凝胶模板法可制备出粒径大小均匀、单分散性良好且生物活性优异的Zn@BGN。当Zn@BGN添加质量分数为15%时，改性复合树脂的力学性能不受影响。

关键词: 锌, 生物活性玻璃纳米颗粒, 溶胶-凝胶模板法, 复合树脂, 力学性能

Abstract:

Objective This study aimed to develop a novel composite resin modified using Zn-doped bioactive glass nanoparticles (Zn@BGN) with biological activity and to investigate the effect of Zn@BGN on the mechanical properties of the modified composite resin. Methods Three types of Zn@BGN with different ratios of zinc-doping ratios were synthesized using the sol-gel template method via the catalysis of dodecylamine. The optimum doping ratio of zinc was explored by performing a biological activity test in vitro. Three modified composite resin experimental groups were prepared by adding Zn@BGN with mass fractions of 10%, 15%, and 20%, and an unmodified composite resin served as the control group. The mechanical properties, such as flexural strength (FS), diametral tensile strength (DTS), compressive strength, and Vickers hardness, of the samples were tested using a universal material testing machine and a microhardness tester. ResultsZn@BGN prepared using the sol-gel template method showed relatively regular spherical particles with a diameter of approximately 150 nm and good monodispersity. In addition, it showed a good biological activity with 1.6%. No significant difference in mechanical properties was found between the modified groups and the control group when the ratios of Zn@BGN incorporation were 10% and 15% (P>0.05). However, the FS and DTS were significantly lower in the modified group with 20% incorporation than in the control group (P<0.05). Conclusion Zn@BGN featuring uniform particle size, good monodispersity, and excellent biological activity can be prepared using the sol-gel template method. Zn@BGN exerts no harmful effect on the mechanical properties of the modified composite resin with 15% incorporation.

Key words: zinc, bioactive glass nanoparticles, sol-gel template method, composite resin, mechanical properties

中图分类号: 

  • R 783.1

表 1

不同掺锌比例BGN各组分质量分数 (%)"

添加物质BGN1-Zn@BGN2-Zn@BGN6-Zn@BGN
ZnO01.62.66.4
CaO32.6323026.2
SiO258.258.258.258.2
P2O59.29.29.29.2

表 2

实验用复合树脂各组分的质量分数 (%)"

材料对照组实验组1实验组2实验组3
Bis-GMA、TEGDMA28282828
CQ1111
DMAEMA1111
无机填料70605550
Zn@BGN0101520

图1

掺锌生物活性玻璃纳米颗粒TEM照片A：BGN；B：1-Zn@BGN；C：2-Zn@BGN；D：6-Zn@BGN。"

图2

掺锌生物活性玻璃纳米颗粒EDS元素分析图A：BGN；B：1-Zn@BGN；C：2-Zn@BGN；D：6-Zn@BGN。"

图3

XRD图谱中HA特征峰图箭头示HA特征峰。"

图4

改性复合树脂力学性能A：FS；B：DTS；C：CS；D：HV。*：P<0.05。"

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