国际口腔医学杂志

国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (6): 739-746.doi: 10.7518/gjkq.2023081

• 综述 • 上一篇    

丝素蛋白水凝胶的改性方法及其在骨组织工程中的应用

陈润智1(),张文涛2,陈枫3,杨帆2()   

  1. 1.浙江中医药大学口腔医学院 杭州 310053
    2.浙江省人民医院（杭州医学院附属人民医院）牙科 杭州 310014
    3.浙江工业大学材料科学与工程学院 杭州 310014
  • 收稿日期:2023-01-01 修回日期:2023-06-06 出版日期:2023-11-01 发布日期:2023-10-24
  • 通讯作者: 杨帆
  • 作者简介:陈润智，住院医师，学士，Email：runzhi_chen@163.com
  • 基金资助:
    浙江省医药卫生科技计划项目(2021KY068)

Modification of silk fibroin-based hydrogels and their applications for bone tissue engineering

Chen Runzhi1(),Zhang Wentao2,Chen Feng3,Yang Fan2()   

  1. 1.School of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, China
    2.Dept. of Stomatology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital of Hangzhou Medical College), Hangzhou 310014, China
    3.School of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China
  • Received:2023-01-01 Revised:2023-06-06 Online:2023-11-01 Published:2023-10-24
  • Contact: Fan Yang
  • Supported by:
    Medical Health Science and Technology Project of Zhejiang Provincial Health Commission(2021KY068)

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摘要：

大面积骨缺损的修复重建需要深入了解骨组织的物理化学特性和生物学特性，并依靠仿生策略，制备出适宜的骨组织支架。丝素蛋白（SF）是一种天然的高分子材料，具有独特的生物学特性。以SF为主要成分制备的水凝胶也是一种有潜力的支架材料。为满足理想骨组织工程支架材料的要求，需要对水凝胶某些性能进行改进。因此，本文从提升水凝胶机械性能，增加水凝胶生物诱导作用，调节水凝胶生物降解性能等方面，回顾总结了应用于骨组织工程时，丝素蛋白水凝胶的改性方法。

关键词: 丝素蛋白, 水凝胶, 骨组织工程, 改性

Abstract:

The repair and reconstruction of large bone defects require a thorough understanding of the physicochemical and biological properties of bone tissue, as well as bionic strategies to prepare suitable bone tissue engineering scaffolds. Silk protein is a natural polymer material with unique biological properties. Hydrogels prepared with silk protein as their main component are also promising scaffold materials. Certain properties of the hydrogel need to be modified to meet the requirements of an ideal scaffold for bone tissue engineering. Therefore, this paper reviews the modification methods to silk fibroin hydrogel when applied to bone tissue engineering in terms of enhancing mechanical properties, increasing biological inductivity, and regulating biodegradability.

Key words: silk fibroin, hydrogels, bone tissue engineering, modification

中图分类号: 

  • R 783.1
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