国际口腔医学杂志

国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (2): 225-234.doi: 10.7518/gjkq.2020048

• 综述 • 上一篇    下一篇

粪肠球菌在口腔及全身系统性疾病中的致病相关因素及其机制的研究进展

税钰森1,吕潇颖1,李静雅1,杨燃2()   

  1. 1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医学院 成都 610041
    2. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院儿童口腔科 成都 610041
  • 收稿日期:2019-05-05 修回日期:2019-09-10 出版日期:2020-03-01 发布日期:2020-03-12
  • 通讯作者: 杨燃
  • 作者简介:税钰森,学士,Email： 1287102779@qq.com
  • 基金资助:
    国家自然科学基金(81800989)

Progress in pathogenic factors and mechanisms of Enterococcus faecalis in oral and systemic diseases

Shui Yusen1,Lü Xiaoying1,Li Jingya1,Yang Ran2()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-05-05 Revised:2019-09-10 Online:2020-03-01 Published:2020-03-12
  • Contact: Ran Yang
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81800989)

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摘要：

作为人类口腔中根管再感染和难治性根尖周炎中的主要致病菌,粪肠球菌能够在根管内恶劣的环境中长期生存,对大多数根管治疗药物和清理消毒的方法都具有一定的抗性,是目前根管治疗的棘手之处。除此之外,它还与一些全身系统性感染,如胃肠道感染、尿道感染等有关。粪肠球菌的致病性与其对宿主的初始黏附、生物膜形成和入侵感染有关。粪肠球菌主要通过表达各种蛋白和糖脂等黏附相关因子实现初始黏附,随后通过调节各种生物膜相关基因的表达形成成熟的生物膜,以对抗机体的杀伤并实现细胞间的交流,最终定植到人体各个部位乃至引起全身感染。本文就粪肠球菌的致病相关因素及其机制的研究进展进行综述。

关键词: 粪肠球菌, 根管再感染, 难治性根尖周炎, 全身系统性感染

Abstract:

Enterococcus faecalis (E. faecalis) is the main pathogen of root canal reinfection and persistent periapical periodontitis in human oral cavity. This species can survive for a long time in the harsh environment of a root canal. E. faecalis has a certain resistance to most root canal therapy drugs, as well as cleaning and disinfection methods. This species presents a major challenge in root canal therapy at present. In addition, E. faecalis is associated with some systemic infections, such as gastrointestinal and urinary tract infection. Its pathogenesis is related to its initial adhesion to the host, biofilm formation, invasive infection, and immune escape. E. faecalis expresses various proteins, glycolipids, and other adhesion to achieve initial adhesion. This species can regulates the expression of various biofilm-associated genes to form a mature biofilm to fight against the body’s deterioration, and realize the communication between cells subsequently. Eventually, E. faecalis colonizes a local area or even the whole body to cause infection. The present review focuses on the pathogenic factors and pathogenesis of E. faecalis.

Key words: Enterococcus faecalis, root canal reinfection, persistent periapical periodontitis, systemic infection

中图分类号: 

  • R780.2
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