国际口腔医学杂志

国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (6): 675-679.doi: 10.7518/gjkq.2019097

• 综述 • 上一篇    下一篇

牙髓干细胞成骨微环境的研究进展

周婷茹1,2,李永生2()   

  1. 1. 昆明医科大学口腔医学院 昆明 650032
    2. 云南省第一人民医院口腔颌面外科 昆明 650032
  • 收稿日期:2019-02-10 修回日期:2019-08-19 出版日期:2019-11-01 发布日期:2019-11-14
  • 通讯作者: 李永生 E-mail:liyongshengkw@sohu.com
  • 作者简介:周婷茹,硕士,Email： 117982359@qq.com
  • 基金资助:
    云南省科学技术厅-昆明医科大学应用基础研究联合专项(2017FE467-209)

Advances of dental pulp stem cells in osteogenic microenvironment

Zhou Tingru1,2,Li Yongsheng2()   

  1. 1. School of Stomatology, Kunming Medical University, Kunming 650032, China
    2. Dept. of Oral and Maxillofacial Surgery, Yunnan First People’s Hospital, Kunming 650032, China;
  • Received:2019-02-10 Revised:2019-08-19 Online:2019-11-01 Published:2019-11-14
  • Contact: Yongsheng Li E-mail:liyongshengkw@sohu.com
  • Supported by:
    This study was supported by Yunnan Provincial Department of Science and Technology-Kunming Medical University Joint Research Fundamental Research Project(2017FE467-209)

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摘要：

牙髓干细胞具有高度增殖及多谱系分化的潜能,使其在联合生物支架材料修复口腔颌面部骨组织缺损方面具有独特的优势和前景,是骨组织工程学中关键的优选细胞。为了更好地实现骨组织的再生,需要为牙髓干细胞的成骨分化提供一个适宜的微环境。本文对牙髓干细胞成骨分化微环境中的细胞因子、支架材料及药物的研究进展进行综述。

关键词: 牙髓干细胞, 成骨分化, 细胞因子, 支架材料, 药物

Abstract:

Dental pulp stem cells possess high proliferation rates and multi-lineage differentiation potential. These features provide them with unique advantages and prospects in the repair of oral and maxillofacial bone tissue with bio-scaffold materials. Hence, dental pulp stem cells are optimised cells in bone tissue engineering. To enhance the regeneration of bone tissue, a suitable microenvironment is necessary for the osteogenic differentiation of dental pulp stem cells. In this review, we will examine the research progress of cytokines, scaffolds and drugs of dental pulp stem cells in an osteogenic microenvironment.

Key words: dental pulp stem cell, osteogenic differentiation, cytokine, scaffold, drug

中图分类号: 

  • Q254
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