Int J Stomatol ›› 2023, Vol. 50 ›› Issue (4): 457-462.doi: 10.7518/gjkq.2023060

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Research progress on the role of extravascular fibrinogen deposition in mucosal diseases

Yang Xiaoyu(),Yuan Quan.()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2022-10-25 Revised:2023-02-16 Online:2023-07-01 Published:2023-06-21
  • Contact: Quan. Yuan;
  • Supported by:
    National Natural Science Foundation of China(82125006)


Fibrinogen is a member of coagulation factors synthesized by liver, and it plays an important role in hemostasis. However, in the case of increased vascular permeability, fibrinogen extravasates and accumulates outside blood vessels. Recognized by integrin receptors on the cell surface, extravascular deposited fibrinogen acts as an immune regulator by mediating leukocyte engagement and activation. Current studies suggest the close association of fibrinogen extravascular deposition with a series of severe mucosal diseases, including oral lichen planus (OLP), oral leukoplakia (OLK), pe-riodontitis, conjunctivitis, and inflammation of digestive tract and lung. This association is indicated to be a potential target for clinical therapy. This article reviewed the recent research progress regarding the relationship between extravascular fibrinogen deposition and mucosal immunity to provide motivations for the development of novel therapeutic methods.

Key words: fibrinogen, mucosal immunity, inflammation

CLC Number: 

  • R 392.11

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