Int J Stomatol

Inter J Stomatol ›› 2019, Vol. 46 ›› Issue (2): 223-227.doi: 10.7518/gjkq.2019022

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Roles of leptomeninges in the effect of chronic peripheral inflammation on neuroinflammation

Yao Wang1,Huixin Lü1,Liuyi Du1,Xinming Gu1,Jingyi Ren1,Weixian Yu2,Yanmin Zhou1()   

  1. 1. Dept. of Implant Center, Hospital of Stomatology, Jilin University, Changchun 130021, China
    2.Key Laboratory of Mechanism of Tooth Development and Jaw Bone Remodeling and Regeneration in Jilin Province, Changchun 130021, China
  • Received:2018-06-13 Revised:2018-12-10 Online:2019-03-01 Published:2019-03-15
  • Contact: Yanmin Zhou E-mail:Zhouym62@163.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81570983);Postgraduate Innovation Fund of Jilin University(2017014);Special Fund of Bethune Medicine, Basic Office of Science and Technology Department of Jilin Province(20160101138JC)

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Abstract:

The pathogenesis of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease dementia and frontotemporal dementia, has remained controversial in academic circles. However, the presence of neuroinflammation is a common feature in these neurodegenerative diseases. Moreover, systemic diseases, such as diabetes, atherosclerosis and peripheral inflammation, are associated with the occurrence and exacerbation of neuroinflammation. Many pieces of clinical evidence showed a correlation between some common kinds of chronic peripheral inflammation, for instance periodontitis, and neurodegenerative disease. To date, some studies indicated that leptomeninges possibly plays as the courier who transfers systemic inflammatory signals in this connection. This review retrospectively analysed the role of leptomeninges in this potential connection between peripheral inflammation neuroinflammation, described the pathological process of neuroinflammation and elucidated the relation between neurodegenerative diseases and paradentitis to develop new therapies and prevention of neurodegenerative diseases.

Key words: leptomeninges, neuroinflammation, peripheral inflammation, periodontitis, inflammatory signal

CLC Number: 

  • R781.4 +2

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