Int J Stomatol

Int J Stomatol ›› 2022, Vol. 49 ›› Issue (4): 489-496.doi: 10.7518/gjkq.2022060

• Reviews • Previous Articles    

Research progress on exosome composite scaffolds in oral tissue engineering

Cai Chaoying1(),Chen Xuepeng1,Hu Ji’an2()   

  1. 1.Dept. of Orthodontics, The Affiliated Hospital of Stomatology, Zhejiang University School of Medicine, School of Stomatology, Zhejiang University, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou 310006, China
    2.Dept. of Pathology, The Affiliated Hospital of Stomatology, Zhejiang University School of Medicine, School of Stomatology, Zhejiang University, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou 310006, China
  • Received:2021-09-25 Revised:2022-03-24 Online:2022-07-01 Published:2022-06-28
  • Contact: Ji’an Hu E-mail:ccy961220@qq.com;hja@zju.edu.cn
  • Supported by:
    National Nature Science Foundation of Zhejiang Province(LY18H140001)

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Abstract:

Defects in various oral and maxillofacial tissues will seriously affect the appearance and function of patients, and effective repair of the defects is the focus of current clinical work. Oral tissue engineering achieves tissue regeneration and functional reconstruction through the application of scaffolds, growth factors and stem cells. The composite materials of stem cells and scaffolds are widely used in the regeneration of oral tissues due to their good regeneration performance. However, the stem cells have poor biocompatibility and low availability, inducing a bottleneck in clinical application. Compared with stem cells, exosomes have lower immunogenicity and higher yield, and are expected to replace stem cells in clinical application. Increasingly abundant scaffold materials can effectively protect and deliver exosomes to target tissues. At present, researches on the application of exosome composite scaffolds have covered the regeneration of jaw bone, articular cartilage, pulp and periodontal tissues. This article reviews the researches upon exosome composite scaffolds in the regeneration of oral and maxillofacial tissues.

Key words: oral tissue engineering, exosome, scaffold, bone regeneration, cartilage regeneration, pulp regeneration, periodontal regeneration

CLC Number: 

  • Q 254

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