Int J Stomatol

Int J Stomatol ›› 2022, Vol. 49 ›› Issue (3): 272-282.doi: 10.7518/gjkq.2022024

• Stem Cells and Regenerative Medicine • Previous Articles     Next Articles

Strategies of vascularization in dental pulp regeneration

Qin Siwen(),Liao Li.()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-08-05 Revised:2021-12-02 Online:2022-05-01 Published:2022-05-09
  • Contact: Li. Liao E-mail:Sven_Qin@outlook.com;lliao@scu.edu.cn
  • Supported by:
    National Nature Science Foundation of China(82071092);Key Research and Development Projects in Sichuan Province(2019YFS0311)

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Abstract:

Pulpitis has one of the highest incidences of oral diseases, and restoring the structure and function of dental pulp is difficult by the commonly adopted treatment methods. Therefore, the strategy of dental pulp regeneration through regenerative medicine has been widely explored. However, the reconstruction of a pulp vascular network is a difficult problem in pulp tissue regeneration because of the special morphological characteristics of root canal and pulp cavity. Studies on pulp angiogenesis strategies have mainly focused on two aspects: orthotopic angiogenesis strategies and graft pre-angiogenesis techniques. In this work, the basic principles of orthotopic angiogenesis in vivo were mainly discussed by systematically analyzing the results of research on angiogenesis in dental pulp regeneration based on dental pulp stem cells (DPSCs): 1) signaling molecules, physical and chemical factors, and regulation of extracellular vesicles during angiogenesis and 2) cell source, vascular network construction conditions, gel scaffold selection, and microenvironment configuration of the pre-angiogenesis system. Studies and trials on the strategies of the vascularization of dental pulp in clinics were also summarized. The application prospect of pre-angiogenesis in the reconstruction of a vascular network in pulp regeneration was also discussed and prospected.

Key words: pulp regeneration, stem cells, angiogenesis, vascularization, pre-vascularization

CLC Number: 

  • R 783

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Tab 1

Signal factors required for the differentiation direction of DPSCs"

分化方向信号因子
成骨细胞水溶性17β雌激素、骨形态发生蛋白2
神经元细胞FGF-b、EGF、神经营养素3、BDNF、孕激素
血管内皮细胞FGF-b、VEGF、IGF-Ⅰ
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