国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (5): 553-559.doi: 10.7518/gjkq.2018.05.010

• 综述 • 上一篇    下一篇

转化生长因子β在牙周炎发生发展中的作用及其机制

田江雪,莫龙义,贾小玥,刘程程,徐欣()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙体牙髓病科 成都 610041
  • 收稿日期:2017-12-31 修回日期:2018-05-28 出版日期:2018-09-01 发布日期:2018-09-20
  • 通讯作者: 徐欣 E-mail:xin.xu@scu.edu.cn
  • 作者简介:田江雪,硕士,Email:2367070214@qq.com
  • 基金资助:
    国家自然科学基金(81430011);四川大学青年教师科研启动基金(2016SCU11056)

Role of transforming growth factor-β in periodontitis

Jiangxue Tian,Longyi Mo,Xiaoyue Jia,Chengcheng Liu,Xin. Xu()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-12-31 Revised:2018-05-28 Online:2018-09-01 Published:2018-09-20
  • Contact: Xin. Xu E-mail:xin.xu@scu.edu.cn
  • Supported by:
    This study was supported by Natural Science Foundation of China(81430011);Young Teachers’ Scientific Research Start Foundation of Sichuan University(2016SCU11056)

摘要:

生长因子是组织修复的基本调节者,在牙周组织再生过程中发挥重要作用。转化生长因子β(TGF-β)是一种调节细胞生长和分化的多肽。近年来的研究表明,TGF-β在牙周炎发生、发展中发挥了十分重要的作用,调节TGF-β信号通路可缓解牙周炎症状,促进牙周组织再生,为治疗牙周炎提供新的思路。本文就TGF-β在牙周炎发生、发展中的作用与机制方面的研究进展进行综述。

关键词: 转化生长因子β, 牙周炎, 炎性骨吸收, 组织再生

Abstract:

Growth factor is the basic regulator of tissue repair and plays an important role in periodontal tissue regeneration. Transforming growth factor-β (TGF-β) is a peptide that can regulate cell growth and differentiation. TGF-β has played an important role in the occurrence and development of periodontitis in previous studies. Thus, regulation of TGF-β expression may alleviate the symptoms of periodontitis and promote the regeneration of periodontal tissue, which might provide new ideas for the treatment of periodontitis. Research progress in this field is reviewed in the paper.

Key words: transforming growth factor-β, periodontitis, inflammatory bone resorption, tissue regeneration

中图分类号: 

  • R781.4 +2
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