转化生长因子β在牙周炎发生发展中的作用及其机制

doi:10.7518/gjkq.2018.05.010

摘要/Abstract

摘要：

生长因子是组织修复的基本调节者,在牙周组织再生过程中发挥重要作用。转化生长因子β（TGF-β）是一种调节细胞生长和分化的多肽。近年来的研究表明,TGF-β在牙周炎发生、发展中发挥了十分重要的作用,调节TGF-β信号通路可缓解牙周炎症状,促进牙周组织再生,为治疗牙周炎提供新的思路。本文就TGF-β在牙周炎发生、发展中的作用与机制方面的研究进展进行综述。

关键词: 转化生长因子β, 牙周炎, 炎性骨吸收, 组织再生

Abstract:

Growth factor is the basic regulator of tissue repair and plays an important role in periodontal tissue regeneration. Transforming growth factor-β (TGF-β) is a peptide that can regulate cell growth and differentiation. TGF-β has played an important role in the occurrence and development of periodontitis in previous studies. Thus, regulation of TGF-β expression may alleviate the symptoms of periodontitis and promote the regeneration of periodontal tissue, which might provide new ideas for the treatment of periodontitis. Research progress in this field is reviewed in the paper.

Key words: transforming growth factor-β, periodontitis, inflammatory bone resorption, tissue regeneration

中图分类号:

R781.4 +2

田江雪,莫龙义,贾小玥,刘程程,徐欣. 转化生长因子β在牙周炎发生发展中的作用及其机制[J]. 国际口腔医学杂志, 2018, 45(5): 553-559.

Jiangxue Tian,Longyi Mo,Xiaoyue Jia,Chengcheng Liu,Xin. Xu. Role of transforming growth factor-β in periodontitis[J]. Inter J Stomatol, 2018, 45(5): 553-559.

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