国际口腔医学杂志

国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (3): 249-254.doi: 10.7518/gjkq.2018.03.001

• 专家论坛 •    下一篇

DNA折纸技术在干细胞领域应用的研究进展

林云锋, 李松航   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院口腔颌面外科 成都 610041
  • 收稿日期:2018-01-14 修回日期:2018-03-16 出版日期:2018-05-01 发布日期:2018-05-01
  • 通讯作者: 林云锋,研究员,博士,Email：yunfenglin@scu.edu.cn
  • 作者简介:林云锋,研究员,博士,Email：yunfenglin@scu.edu.cn

Research progress on application of DNA origami in stem cell field

Lin Yunfeng, Li Songhang   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-01-14 Revised:2018-03-16 Online:2018-05-01 Published:2018-05-01

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摘要： DNA折纸技术是近年来新提出的一种DNA自组装方法,可设计特定的DNA序列,遵循碱基互补配对原则来构建出更为复杂的纳米结构与纳米图案。近期发现通过DNA折纸技术构建出的DNA四面体纳米结构（TDN）在干细胞领域有着巨大应用潜能。本文就TDN结构、生物学特性以及在干细胞领域的应用进行综述。

关键词: DNA纳米结构, DNA四面体, 干细胞, 分化, 组织再生

Abstract: DNA origami is a newly proposed DNA self-assembly method in recent years. It can design specific DNA sequences and follow the principle of complementary base pairing to construct more complex nanostructures and nanopatterns. The recent discovery of tetrahedral DNA nanostructure (TDN) constructed by DNA origami has great application potential in the field of stem cells. In this study, we reviewed the structure and biological properties of TDN, and the applications of TDN in the field of stem cells.

Key words: DNA nanostructure, tetrahedral DNA nanostructure, stem cell, differentiation, tissue regeneration

中图分类号: 

  • Q75
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