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Table of Content

    01 September 2013, Volume 40 Issue 5 Previous Issue    Next Issue
    Clear aligner treatment: Current and future Chen Song. (State Key Laboratory of Oral Diseases, Dept. of Orthodontics, West China Hospital of Stomatology
    Chen Song.
    Inter J Stomatol. 2013, 40 (5):  561-564.  DOI: 10.7518/gjkq.2013.05.001
    Abstract ( 1893 )   HTML ( 13 )   PDF(pc) (1198KB) ( 1957 )   Save

    In this article, the biomechanical characteristics and tooth movement control of clear aligner were discussed, the treatment of complicated cases by combiningclear aligner withother materials is explained, and the future development or breakthrough of clear aligner is presented.

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     Opportunities and challenges of cranial and maxillofacial tissue regeneration
    Chen Faming, Zhou Yongsheng, Lin Yunfeng, Zhang Yufeng.
    Inter J Stomatol. 2013, 40 (5):  565-567.  DOI: 10.7518/gjkq.2013.05.002
    Abstract ( 1441 )   HTML ( 13 )   PDF(pc) (1228KB) ( 1269 )   Save

    In common clinically, cranial and maxillofacial tissue defects, serious impact on the various function and survival quality of patients, cranial and maxillofacial tissue defect repair reconstruction increasingly brought to the attention of the people. In recent years, the rapid development of tissue engineering techniques for complex tissue and organ regeneration brings hope, has become a hot topic of researchers. Schools of thought contend in current column special invited four cranial and maxillofacial tissue regeneration of the well-known experts in the field of tissue engineering is facing opportunities and challenges were discussed, in order to bring some enlightenment for the clinical and research work.

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    Expression of T-bet, GATA-3, and Foxp3 in peripheral blood of patients with recurrent aphthous ulcer
    Nie Yujie1,2, Cai Yang1, Feng Qiujing3.
    Inter J Stomatol. 2013, 40 (5):  568-571.  DOI: 10.7518/gjkq.2013.05.003
    Abstract ( 1327 )   HTML ( 3 )   PDF(pc) (1252KB) ( 853 )   Save

    Objective To elucidate the underlying role of T-bet, GATA-3, and Foxp3 in the immune etiology of human with recurrent aphthous ulcer(RAU). Methods Peripheral blood mononuclear cells(PBMCs) were isolated by density gradient centrifugation from 33 cases of minor RAU and 30 cases of healthy controls. The expression levels of T-bet, GATA-3, and Foxp3 mRNA in PBMCs were investigated by reverse transcription-polymerase chain reaction. The cellular and humoral immune status of patients with RAU was investigated by flow cytometry and enzyme-linked immunosorbent assay. Results CD4, CD4/CD8, T+B+NK cells were significantly lower in the RAU group than in the control group(P<0.01). Immunoglobulin(Ig) A was lower in the RAU group than in the control group(P<0.05). IgM and 50% hemolytic complement were significantly higher in the RAU group than in the control group(P<0.05). The expression level of T-bet mRNA and Foxp3 mRNA, the ratio of T-bet/GATA-3 in the RAU group were lower than that in the control group(P<0.01). Meanwhile, the expression level of GATA-3 mRNA in the RAU group was higher than that in the control group(P<0.05). A positive correlation was detected between Foxp3 mRNA level and T-bet/GATA-3 ratio(r=0.404, P=0.02). Conclusion Most RAU patients have immune cells reduced and humoral immune disorder. The increased expression of GATA-3 and decreased expression of T-bet might be one of the mechanisms of T helper cell(Th)1/Th2 imbalance in RAU, accounting for the abnormal immune function in patients with RAU. The decrease in regulatory T cells might be a contributing factor toward Th1/Th2 imbalance in RAU.

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    Detection of Porphyromonas gingivalis in SD rats with chronic periodontitis
    Lin Mu, Ren Xiuyun, Chang Le, Yue Zijie, Shi Xuexue, Sun Lili.
    Inter J Stomatol. 2013, 40 (5):  572-576.  DOI: 10.7518/gjkq.2013.05.004
    Abstract ( 1546 )   HTML ( 3 )   PDF(pc) (1282KB) ( 833 )   Save

    Objective To detect Porphyromonas gingivalis(P.gingivalis) in the carotid artery of rats with chronic periodontitis and to explore the possible relationship between P.gingivalis and chronic periodontitis. Methods Fortytwo SD rats were randomly divided into six groups: Group A(control group), group B1(non-intervention group), group B2(scaling and root planning group), group B3(systemic antibiotics group), group B4(tooth extraction group), and group B5(tooth extraction with antibiotics for 3 d). Each group accepted the corresponding measures and periodontal interventions to establish the animal model. After the death of experimental animals, P.gingivalis was semi-quantitatively detected in the right carotid artery tissue by 16S rRNA polymerase chain reaction. Results P.gingivalis was detected in all groups. The relative quantity of P.gingivalis significantly increased in groups B1 to B5 compared with that in group A(P<0.01). The relative quantity of P.gingivalis was the highest in group B1, showing a significant difference with B4 and B5(P<0.05). A statistically significant difference in the relative quantity of P.gingivalis was also found between B1 and B5(P<0.01). Conclusion P.gingivalis is a periodontal resident pathogen that can invade endothelial cells, leading to associative function disorders. In addition, extraction of loose teeth without delay eliminates P.gingivalis. The intake of antibiotics after tooth extraction decreases the adhesion of P.gingivalis to endothelial cells.

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    Improved application of a 45° angle turbine drill in impacted wisdom tooth extraction
    Cai Yongtao1,2, Luo Shunyun1, Li Xuyan2
    Inter J Stomatol. 2013, 40 (5):  577-579.  DOI: 10.7518/gjkq.2013.05.005
    Abstract ( 1682 )   HTML ( 5 )   PDF(pc) (1211KB) ( 962 )   Save

    Objective To compare the effect of traditional turbine drilling applications and submersible drilling conjunction with triangular gingival cutting in complex wisdom tooth extraction. Methods Sixty-four cases of lower impacted wisdom teeth were randomly divided into two groups of 32: Experimental and control. The traditional turbine drill extraction method was used in the control group, whereas submersible drilling conjunction with triangular gingival cutting was employed in the experimental group. Surgical time and postoperative complications were recorded for statistical analysis. Results The average operative times for the experimental and control groups were 26.1 and 36.3 min, respectively. A significant difference in the time of surgery, postoperative pain, postoperative swelling, and trismus was found between the experimental and control groups(P<0.05). Results showed that the experimental group had better outcome than the control group. Conversely, no significant difference in postoperative gum bleeding and tearing was found between the two groups(P>0.05). Conclusion Submersible drilling conjunction with triangular gingival cutting is an effective method of complex impacted wisdom tooth extraction because it can shorten the operation time, lessen postoperative pain and swelling, and limit mouth opening.

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    A retrospective analysis of 215 Uyghur patients with cleft lip and palate
    Duolikun Wupuer, Muhetaer Huojia, Mireguli Wumaer, Li Jun, Yan Guangpeng, Kamili Maimaitiming.
    Inter J Stomatol. 2013, 40 (5):  580-582.  DOI: 10.7518/gjkq.2013.05.006
    Abstract ( 1551 )   HTML ( 3 )   PDF(pc) (1153KB) ( 825 )   Save

    Objective This study aims to analyze the clinical data of Uyghur cases of cleft lip and palate to provide more information on the prevention for this malformation. Methods Two hundred and twenty-five cases were collected from patients treated in the People’s Hospital of Xinjiang Uyghur Autonomous Region, from January 2009 to August 2012. A retrospective clinic study was carried out. Results The study included 18 cases of cleft lip, 115 cases of cleft lip with cleft palate, and 80 cases of cleft palate. The cases of unilateral cleft lip with or without palate cases were higher than the bilateral cases. In all cases, patients who were born in July to September were fewer than those born in other seasons. Most of the parents of the patients were from the countryside. Fifty-five cases had mothers underwent danger factor. Conclusion The ratio of cleft lip with cleft palate was higher than the other types in Uyghur patients. The cases of unilateral cleft lip with or without palate cases were more than the bilateral cases, and males were more than females. The cleft lip and/or palate formation may be related with multiple genes and environmental condition in the early stage of the embryo.

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    Initial foundation of oral histopathology computer-assisted instruction system
    Xue Chaoran, Luo Weijia, Xiong Yi, Liu Xuejiao, Geng Ning.
    Inter J Stomatol. 2013, 40 (5):  583-585.  DOI: 10.7518/gjkq.2013.05.007
    Abstract ( 1686 )   HTML ( 2 )   PDF(pc) (1120KB) ( 1252 )   Save

    Objective This project aims to develop an interactive computer-assisted instruction system for oral histopathology and enhance the effectiveness of teaching based on the digital slide scanning system of Aperio Scanscope. Methods We developed the system through the following steps: 1)Preliminary investigation on user requirement; 2)Establishment of corresponding database structure; 3)Programming for terminal software and database management software; 4)Establishment of the interactive computer-assisted instruction system for oral histopathology. Results Based on the Client/Server(C/S) architecture, the system is divided into four parts: Virtual slide database, related knowledge database, interactive teaching platform, and Q&A platform. In addition, the system has ten major functions. Conclusion Strengthening the contact of computer-assisted instruction systems among branches of stomatology, enhancing the user experience, establishing the teaching resource database and corresponding management mechanism, and teaching mode reform may be the direction of the development in interactive computer-assisted instruction system in stomatology.

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    Effect observation of modified occlusion pad removable appliance in the treatment of 33 cases of children deciduous teeth cross bite
    Yao Sen1, Feng Hongjie2.
    Inter J Stomatol. 2013, 40 (5):  586-587.  DOI: 10.7518/gjkq.2013.05.008
    Abstract ( 1775 )   HTML ( 16 )   PDF(pc) (1135KB) ( 885 )   Save

    Objective This study aims to observation the effects of the modified occlusion pad removable appliance in the treatment of children deciduous anterior teeth overbite. Methods Thirty-three patients were treated with modified occlusion pad removable appliance. Results After 3 to 4 months of treatment of modified occlusion pad removable appliance, the overbite was improved, with satisfactory result. Conclusion The modified occlusion pad removable appliance exhibited remarkable results.

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    Effects of quaternized chitosan on the cell proliferation and cell cycle of human periodontal ligament cells
    Ji Qiuxia, Yuan Changqing, Song Wenbin, Wu Hong.
    Inter J Stomatol. 2013, 40 (5):  588-591.  DOI: 10.7518/gjkq.2013.05.009
    Abstract ( 1474 )   HTML ( 4 )   PDF(pc) (1251KB) ( 808 )   Save

    Objective To evaluate the effects of quaternized chitosan[N-(2-hydroxy-3-trimethylammonium) propylchitosan chloride] (HTCC) on the proliferation and cell cycle activities of human periodontal ligament cells(HPDLCs) with different concentrations compared with chitosan(CS). Investigating the mechanisms underlying the use of HTCC is necessary. Methods Primary cells were isolated from human periodontal ligament. HPDLCs were cultured and characterized by immunocytochemistry. The effect of varying concentrations(2 000, 1 000, 100, 50, 10, 3, 1.5, 1, 0.5, and 0.2 mg•L-1) of HTCC and CS on HPDLCs were evaluated by methyl thiazolyl tetrazolium(MTT) assay. Flow cytometry (FCM) was used to determine the cell cycle states of HPDLCs with HTCC(3 g•L-1, 1 g•L-1, and 3 mg•L-1) and CS(3 g•L-1 and 3 mg•L-1). The SPSS 13.0 software package was used for statistical analysis. Results Immunocytochemistry results show that the cells stained positively to antibodies against vimentin and stained negatively to antibodies against cytokeratin, indicating that the cells were external embryo mesenchymal cells. The MTT assay showed decreased optical density(OD) values of HTCC at concentrations of 2 000, 1 000, 100, and 50 mg•L-1 and increased OD values at concentrations of 10, 3, 1.5, 1, 0.5, and 0.2 mg•L-1. CS accelerated the proliferation of HPDLC at all tested concentrations. Compared with the control, a significant difference was observed at 5 d(P<0.01). FCM results revealed that HTCC at 3 g•L-1 and 1 g•L-1 induced apoptosis, whereas CS at 3 g•L-1 and 3 mg•L-1 induced a decrease in S% and increase in G2%. A significant difference(P<0.01) was observed compared with the control. Conclusion HTCC and CS affected the proliferation of HPDLCs by changing the cell cycle. HTCC at concentrations of 50 mg•L-1 to 2 000 mg•L-1 inhibited the proliferation of HPDLCs and exhibited strong cytotoxicity. HTCC at concentrations of 0.2 mg•L-1 to 10 mg•L-1 stimulated the proliferation of HPDLCs. Different cytobiological effects of HTCC and CS on cell cycle were observed.

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    Comparison of general angle magnitudes measured using two kinds of cephalometric measuring software
    Luo Houzhuo, Jia Lihui, Li Chengri, Zhang Wenjun, Zhang Xiaodong.
    Inter J Stomatol. 2013, 40 (5):  592-594.  DOI: 10.7518/gjkq.2013.05.010
    Abstract ( 1895 )   HTML ( 2 )   PDF(pc) (1142KB) ( 1157 )   Save

    Objective To investigate and compare the general angles on coronal lateral position using a threedimensional analyzing software and the conventional Winceph 8.0 software. Methods Forty pre-orthodontic patients were radiographed with cone-beam computed tomography(CBCT) techniques. According to the identical condition, CBCT data were converted to cephalograms using Invivo Dental 5.0 software. Certain landmarks were measured using the threedimensional analyzing software and Winceph 8.0, and the measurements were repeated twice for each method. All data were subjected to statistical analysis, and rank sum test was used to determine the difference between the three-dimensional analyzing software and Winceph 8.0. Results No obvious differences on the general angle magnitudes at the coronal lateral position were observed between the three-dimensional analyzing software and Winceph 8.0. Conclusion The results from the measurement by the two methods did not show significant differences. This finding indicates that the threedimensional analyzing software and Winceph 8.0 exhibit the same performance. Moreover, the three-dimensional analyzing software indicated distinct superiority on certain landmarks.

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    Two methods of health education for families of children with cleft lip and palate in peropetative period
    Qi Li, Zheng Cangshang, Xiao Fenghua, Cai Miaoli.
    Inter J Stomatol. 2013, 40 (5):  595-597.  DOI: 10.7518/gjkq.2013.05.011
    Abstract ( 1317 )   HTML ( 1 )   PDF(pc) (1138KB) ( 709 )   Save

    Objective To explore the better clinical effect of health education for families of children with cleft lip and palate in preopetative period. Methods Two hundred and two families of children with cleft lip and palate were randomly divided into 2 groups: Experimental group and the control group. Control group were treated by conventional health education, experimental group using improved health education. The cognitive effects of families of children were evaluated after accepting two methods of health education. Results The difference between the two sets of health education methods in families of children was statistically significant on the cognition to the disease and child care(P<0.01). Conclusion Improved health education can improve the cognitive abilities of families of children with cleft lip and palate, and it has a certain clinical application value.

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    Teenager with six newly formed impacted supernumerary teeth: A case report
    Liu Qihong1, Hua Chengge2, Tan Lijun2
    Inter J Stomatol. 2013, 40 (5):  598-599.  DOI: 10.7518/gjkq.2013.05.012
    Abstract ( 1457 )   HTML ( 4 )   PDF(pc) (1247KB) ( 663 )   Save

    Supernumerary teeth are those that exceed the normal dental formula. In most cases, the number of supernumerary teeth is one or two. A patient rarely has more than three supernumerary teeth. Previous reports only focused on supernumerary teeth that have been formed. In this study, we present a boy who hade normal number of teeth when he was 10 years old and had six impacted newly formed supernumerary teeth two years later.

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    Research progress on restoration of residual crown and root in deciduous teeth
    Chen Aihua, Huang Hua.
    Inter J Stomatol. 2013, 40 (5):  600-603.  DOI: 10.7518/gjkq.2013.05.013
    Abstract ( 1207 )   HTML ( 7 )   PDF(pc) (1245KB) ( 1109 )   Save

    Restorative therapy for residual crown and root resulting from early childhood caries has been very difficult to perform in clinical settings. However, few non-infected tooth structures may be retained when gross carious lesions are removed. As a result, restoration by the traditional method or short non-absorbable post method will cause teeth to fall off easily because of poor resistance and retention by the teeth. Recently, biological restoration has become a novel restorative method for treating the residual root of deciduous teeth. This technique has turned out to be an acceptable and effective treatment method. However, certain ethical issues on this treatment method arise, which can potentially lead to rejection or a risk of cross infection to the recipient. The application of polylactic acid(PLA) absorbable material as intracannel fixation in children has now resolved these problems. Studies have demonstrated that PLA is a promising material for the restorative treatment of residual root in deciduous teeth. This article presents a review of the research progress on restorative therapy for residual crown and root of deciduous teeth in recent years.

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    Etiological and epidemiological profiles of dental erosion
    Gu Hao, Tao Danying, Feng Xiping.
    Inter J Stomatol. 2013, 40 (5):  604-607.  DOI: 10.7518/gjkq.2013.05.014
    Abstract ( 1571 )   HTML ( 4 )   PDF(pc) (1154KB) ( 1764 )   Save

    Dental erosion is defined as the irreversible loss of dental hard tissue induced mainly by intrinsic and extrinsic acid not involving bacteria. Dental erosion has gained considerable attention because of its increased domestic and international prevalence. This paper presents a review of the domestic and international etiological and epidemiological profiles of dental erosion.

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    Cytotoxicity and genotoxicity of dental filling materials utilized in endodontic thera
    Yan Wen, Li Wei.
    Inter J Stomatol. 2013, 40 (5):  608-611.  DOI: 10.7518/gjkq.2013.05.015
    Abstract ( 1722 )   HTML ( 10 )   PDF(pc) (1219KB) ( 983 )   Save

    The filling materials utilized in root canal therapy have a long-term retention in the oral cavity. Safety and biocompatibility of the filing materials always draw people’s attention. The biocompatibility of these materials has a direct impact on the quality of root canal filling and periapical tissue repair response. Biocompatibility tests, including histology, cytology, molecular genetics, and biological evaluation of different levels, cytotoxicity, and genotoxicity of materials, have been successfully utilized to evaluate the biocompatibility of the materials. This study is a review about the cytotoxicity and genotoxicity of root canal filling materials.

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    Correlation and mechanism between periodontitis and hyperlipidemia
    Lü Chunxu, Sun Qinfeng
    Inter J Stomatol. 2013, 40 (5):  612-615.  DOI: 10.7518/gjkq.2013.05.016
    Abstract ( 1346 )   HTML ( 3 )   PDF(pc) (1222KB) ( 1653 )   Save

    Chronic diseases that cause serious adverse effects to human health, specifically periodontitis and hyperlipidemia, as well as the relationship between them have received increased research attention. These diseases may be related to bacteria and bacterial metabolites, products of inflammation, and immune responses. The present review introduces the clinical correlation and biological mechanisms between periodontitis and hyperlipidemia.

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    Application of controlled release technology in periodontal tissue regeneration
    Zhang Jing, Li Shu.
    Inter J Stomatol. 2013, 40 (5):  616-618.  DOI: 10.7518/gjkq.2013.05.017
    Abstract ( 1312 )   HTML ( 1 )   PDF(pc) (1207KB) ( 479 )   Save

    Periodontitis is a chronic inflammatory disease that causes progressive destruction of the tooth-supporting apparatus, which potentially leads to tooth loss. Current methods to reconstruct lost periodontal tissues mainly rely on tissue-engineering technology. The release and delivery of growth factors at an optimized ratio in a specific spatiotemporal mode is thus of particular importance. This study reviews research progress on controlled release technologies in periodontal regeneration medicine.

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    Research progress on oral fungal infections
    Shen Jie, Zhou Wenming.
    Inter J Stomatol. 2013, 40 (5):  619-624.  DOI: 10.7518/gjkq.2013.05.018
    Abstract ( 1350 )   HTML ( 5 )   PDF(pc) (1232KB) ( 2736 )   Save

    As the use of antibiotics and immunosuppressive drugs has increased in recent years, the incidence of oral fungal infections has also gradually increased. Pathogens that frequently cause oral fungal infection include Candida, Cryptococcus, Aspergillus, Sporotrichum schenckii, Mucor, Geotrichum, Histoplasma capsulatum, Paracoccidioides brasiliensis, Blastomyces dermatitidis, and Phialophora. Hosts with immunodeficiency and chronic diseases may achieve strengthened oral nursing by avoiding invasive fungal infections and treatment with antifungal drugs. This study reviews research progress on pathogenic fungi as well as the causes, clinical manifestations, and diagnosis of oral cavity fungal infections.

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    Function of microorganisms in tongue coating in oral malodor
    Weng Jinlong1, Chen Xiaochi2.
    Inter J Stomatol. 2013, 40 (5):  625-628.  DOI: 10.7518/gjkq.2013.05.019
    Abstract ( 1615 )   HTML ( 10 )   PDF(pc) (1216KB) ( 1457 )   Save

    Although the dorsum of the tongue harbors one of the most complex microbiological niches in human ecology, information on the relationship of tongue flora with health and disease is very limited. Similarly, the nature of the tongue coating and the factors that influence its development and composition are almost unknown. Recently, the agents that cause oral malodour have been identified. These agents include volatile sulfur compounds, propionic acid, butyric acid, cadaverine, putrescine, indole, skatole, etc., and especially, hydrogen sulfide and methyl mercaptan. Furthermore, these substances had a significantly positive correlation with tongue biofilms. Tongue coating can be successfully managed by combining mechanical cleaning(brushing, tongue brushing, tongue scraping) and various chemical solutions. This combination can effectively reduce bad breath. The purpose of this review is to evaluate the present knowledge in tongue niche and tongue coating by focusing on the microbiology of the tongue biofilm. Special emphasis will be given on the evaluation of the evidence linking tongue biofilm with oral halitosis.

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    Features of five osteoporosis rat models
    Zhang Yarong, Tang Ge, Liu Shan, Yu Haiyang.
    Inter J Stomatol. 2013, 40 (5):  629-633.  DOI: 10.7518/gjkq.2013.05.020
    Abstract ( 2386 )   HTML ( 24 )   PDF(pc) (1156KB) ( 2744 )   Save

    Osteoporosis is a common disease among elderly people. This disease compromises the dental prosthetic effect. Clinical prevention is not ideal because of insufficient understanding of osteoporosis pathogenesis. For ethical reasons, animal models are usually utilized for research. This study reviews the main features of five established rat models of osteoporosis, which will help in establishing an appropriate animal model of osteoporosis.

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    Psychological factors and treatment of temporomandibular joint disturbance syndrome
    Yong Xiangzhi, Tang Lili, Nong Xiaolin.
    Inter J Stomatol. 2013, 40 (5):  634-637.  DOI: 10.7518/gjkq.2013.05.021
    Abstract ( 1836 )   HTML ( 13 )   PDF(pc) (1153KB) ( 1184 )   Save

    Temporomandibular joint disturbance syndrome(TMJDS) is a common disease in the oral-maxillofacial region. The cause of this disease remains unknown because of multiple pathogenic factors. Considering studies conducted worldwide as references, this study discusses the epidemiology and research progress on animal models and the clinical psychology of TMJDS. It also probes into the psychological factors of TMJDS and evaluates the application of psychological treatments to address the disease.

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    Functional reconstruction of tongue defect repair
    Liu Jie1, Li Jun1, Muhetaer Huojia2
    Inter J Stomatol. 2013, 40 (5):  638-641.  DOI: 10.7518/gjkq.2013.05.022
    Abstract ( 1908 )   HTML ( 9 )   PDF(pc) (1144KB) ( 1985 )   Save

    The tongue has a special physiological function, and tongue defect reconstruction is a challenge for maxillofacial surgery. To date, tongue defect repair has developed from morphology and volume recovery to reconstruction of dynamic functions. Tongue defect reconstruction is widely recognized, frequently studied, and partly understood. This study summarizes research progress on surgical flaps, allotransplantation, and tissue-engineered materials for reconstructing tongue defects. It also discusses function evaluation after repair and functional muscle transfer for tongue reconstruction.

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    Research progress on carcinoma ex-pleomorphic adenoma
    Li Tian, Sun Guowen, Tang Enyi.
    Inter J Stomatol. 2013, 40 (5):  642-644.  DOI: 10.7518/gjkq.2013.05.023
    Abstract ( 2145 )   HTML ( 20 )   PDF(pc) (1272KB) ( 1948 )   Save

    Carcinoma ex-pleomorphic adenoma is a rare and highly malignant type of salivary gland tumor. The tumor, which often occurs in the parotid gland, palate, and submandibular gland, is difficult to diagnose, easily recurs, and has poor prognosis. This paper presents a comprehensive overview of research progress on the clinical manifestations, pathological features, diagnosis, treatment, and prognosis of the tumor.

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    Application of data mining technology in tumor research
    Chen Yiming, Ji Tong.
    Inter J Stomatol. 2013, 40 (5):  645-647.  DOI: 10.7518/gjkq.2013.05.024
    Abstract ( 1435 )   HTML ( 4 )   PDF(pc) (1236KB) ( 1828 )   Save

    In recent years, data mining application in the medical field has been broadened. Likewise, numerous achievements in tumor study exist. This technology provides an effective approach to filter the risk factors and discover oncogenes to predict tumor. It also offers technical support to study tumor pathogenesis further. Combined with imaging, molecular biology, and other technologies, data mining provides a more accurate early tumor diagnosis. Researchers can predict the survival periods of patients by analyzing tumor-associated factors. With the development of data mining technology, numerous achievements in the field of tumor study are expected.

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    Clinical application of implant anchorage for vertical control in orthodontics
    He Han, He Hong.
    Inter J Stomatol. 2013, 40 (5):  648-652.  DOI: 10.7518/gjkq.2013.05.025
    Abstract ( 1350 )   HTML ( 4 )   PDF(pc) (1157KB) ( 1759 )   Save

    Effective vertical control is the key for successful orthodontic treatments and to receive the ideal outcome. In recent years, with the widespread application of implant anchorage in orthodontic therapy, increasing emphasis has been laid on vertical control via implant anchorage. This article aims to review the recent researches about the use of implant anchorage for vertical control in orthodontic treatments. Compared with traditional vertical control technologies, implant anchorage application was analyzed from three aspects: Recent applications, clinical research, and possible risks. Meanwhile, the bright future of broadening and promoting vertical control technologies by implant anchorage is expected, hoping to provide some ideas and evidence for clinical practice.

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    Influence of bisphosphonates on dental implants
    Su Meiying1, Shi Bin1, 2, Zhang Yufeng1, 2.
    Inter J Stomatol. 2013, 40 (5):  653-656.  DOI: 10.7518/gjkq.2013.05.026
    Abstract ( 1595 )   HTML ( 5 )   PDF(pc) (1151KB) ( 2213 )   Save

    Both osteoporosis and tooth loss are prevalent in the elderly population. Thus, implant use is essential in solving the problem of missing teeth in osteoporotic patients undergoing bisphosphonate treatment. Incidents of osteonecrosis of the jaw, known as bisphosphonate-related osteonecrosis of the jaw(BRONJ), have been reported in persons using bisphosphonates and undergoing invasive dental implants. Many studies show that the risk for bisphosphonateinduced osteonecrosis may be influenced by the route of drug administration, the potency and duration of use, as well as other local and systematic factors. This study reviews the risk factors of bisphosphonates that affect bone implants, the pharmacological effects of bisphosphonates, how bisphosphonates lead to implant failure, and how to control BRONJ.

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    The role of Fusobacterium nucleatum in dental plaque biofilms
    Xue Honglei1, Yang Deqin2.
    Inter J Stomatol. 2013, 40 (5):  657-660.  DOI: 10.7518/gjkq.2013.05.027
    Abstract ( 1675 )   HTML ( 4 )   PDF(pc) (1252KB) ( 1335 )   Save

    Fusobacterium nucleatum(F. nucleatum) is a prominent component in dental plaque biofilms. It is also regarded as a key organism for dental plaque biofilm formation, shifts, metabolic exchanges, and horizontal gene transfer. Meanwhile, F. nucleatum is an important pathogen implicated in periodontitis and dental caries, and it acts as a “bridge” of coaggregation between supragingival and subgingival plaque microbiota. In summary, F. nucleatum significantly affects oral health balance. This review focused on F. nucleatum and its role in the ecology of dental plaque biofilms.

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    Bacterial genes and proteins expressed differentially in biofilm and planktonic conditions
    Li Xinyi, Duan Dingyu, Xu Yi.
    Inter J Stomatol. 2013, 40 (5):  661-666.  DOI: 10.7518/gjkq.2013.05.028
    Abstract ( 1835 )   HTML ( 11 )   PDF(pc) (1267KB) ( 1470 )   Save

    A number of infectious diseases are closely related to biofilms in humans. The resistance of biofilms to antibiotics is over 100- to 1 000-fold higher than that of planktonic cells, causing great difficulty in treating bacterial infectious diseases. Studies on genes and proteins in bacteria living in planktonic converse biofilms have steadily increased with the aim of discovering more effective measures to destroy the biofilm or restrain biofilm development. This study reviews the gene and protein expressions of common pathogenic bacteria in developing and stationary phase biofilms as well as quorum sensing signal conduction in biofilms.

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    Research progress on Streptococcus gordonii AtlS autolysis
    Wang Lin, Liu Min, Hao Yuqing, Liu Yaling.
    Inter J Stomatol. 2013, 40 (5):  667-669.  DOI: 10.7518/gjkq.2013.05.029
    Abstract ( 1633 )   HTML ( 2 )   PDF(pc) (1244KB) ( 890 )   Save

    Streptococcus gordonii(S.gordonii) AtlS autolysin plays critical roles in the formation of normal cell walls, development of biofilms, and production of autolysin. The expression of AtlS is subject to complex regulation and modulates stress tolerance, biofilm formation, and extracellular DNA release. This study introduces the expression, twocomponent systems, and related regulatory mechanisms of S.gordonii AtlS autolysis.

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    Three-dimensional structure and related functional epitopes of the surface protein of oral streptococci
    Yang Ningning, He Kuifang.
    Inter J Stomatol. 2013, 40 (5):  670-673.  DOI: 10.7518/gjkq.2013.05.030
    Abstract ( 1549 )   HTML ( 1 )   PDF(pc) (1222KB) ( 674 )   Save

    Surface proteins, such as AgⅠ/Ⅱ , P1, PAc, SpaP, SspA, and SspB, are widely observed in oral Streptococcus. These proteins mediate the attachment of Streptococcus mutans, Streptococcus sobrinus, Streptococcus gordonii, and so on to tooth surfaces, influence the formation of dental plaque, and are the main virulent factors for the development of caries diseases. The crystal structure of region V of AgⅠ/Ⅱ (SpaP-V) was first studied, after which research on the 3D structures of the full-length AgⅠ/Ⅱ as well as regions V and C of SspB was performed. The 3D structures of AgⅠ/Ⅱ were also gradually elucidated to better explain the mechanism of function of the proteins. Research advances on the 3D structure of Ag Ⅰ/Ⅱ and the related functional epitopes are finally reviewed.

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    Relationship between survivin and oral diseases
    Li Qian1, Pan Yaping1,2.
    Inter J Stomatol. 2013, 40 (5):  674-677.  DOI: 10.7518/gjkq.2013.05.031
    Abstract ( 1207 )   HTML ( 4 )   PDF(pc) (1200KB) ( 653 )   Save

    Survivin, a member of the inhibitor of apoptosis protein family, functions as a regulator of mitosis and cell-death decisions. Survivin affects the initiation and progression of diseases by interfering with cell proliferation and apoptosis. In recent years, the relationship between survivin and oral diseases has attracted considerable research attention. This article focuses on the biological functions of survivin as well as relevant research progress in oral cancer, periodontal diseases, and salivary gland development.

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    Nucleotide-binding oligomerization domain protein and its expression in dental pulp
    Jiang Lan, Song Zhi, Lin Zhengmei.
    Inter J Stomatol. 2013, 40 (5):  678-682.  DOI: 10.7518/gjkq.2013.05.032
    Abstract ( 1054 )   HTML ( 2 )   PDF(pc) (1225KB) ( 803 )   Save

    Recent studies reveal that the nucleotide-binding oligomerization domain(NOD) is an important family of cytosolic pattern recognition receptors that have a distinct function in the innate immune system. The recognition and interaction between NOD and pathogen-associated molecular patterns are related to many types of clinical diseases. This study reviews the biological characteristics of NOD, immune functions of odontoblasts and dental pulp fibroblasts, and the expression of NOD in dental pulp cells. The results provide novel insights that can help improve the current understanding of the pathogenesis of pulpitis, prevention of the disease, and endodontic treatment.

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    Function and influence factors of podoplanin in epithelial mesenchymal transition
    Li Yaoyin, Gao Yan.
    Inter J Stomatol. 2013, 40 (5):  683-686.  DOI: 10.7518/gjkq.2013.05.033
    Abstract ( 1338 )   HTML ( 1 )   PDF(pc) (1147KB) ( 689 )   Save

    In the tumor invasion process, the epithelial-mesenchymal transition(EMT) program is activated. This process is characterized by a change in epithelial cell polarization, cytoskeleton modification, intercellular cohesive marker loss, and mesenchymal marker acquisition. Studies have indicated that podoplanin enhances the mobility of embryonic cells and tumor cells, which activate the EMT. This article reviews the mechanism and influence factors of podoplanin in inducing tumor invasion through EMT.

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    Function of heparan sulfate proteoglycan on nerve regeneration after injury
    Zhu Li1, Wu Lianjun2, Wang Yanliang2.
    Inter J Stomatol. 2013, 40 (5):  687-690.  DOI: 10.7518/gjkq.2013.05.034
    Abstract ( 1527 )   HTML ( 1 )   PDF(pc) (1201KB) ( 1200 )   Save

    Heparan sulfate proteoglycan(HSPG) is found in the extracellular matrix and composed of a core protein and heparan sulfate. HSPG may be categorized into four families, namely, syndecans, glypicans, perlecans, and agrins, all of which broadly participate in various processes from axonal growth and motor end-plate recovery to skeletal muscle cell regeneration. This review focuses on HSPG and its guiding function in the axonal growth process. It also discusses changes in the neuronal damage expression-repair process and the function of HSPG in the formation process of neural muscle junctions.

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    Function of perlecan in bone regeneration
    Wang Yi1, Wang Yanliang2, Hu Rongdang1.
    Inter J Stomatol. 2013, 40 (5):  691-694.  DOI: 10.7518/gjkq.2013.05.035
    Abstract ( 1655 )   HTML ( 3 )   PDF(pc) (1222KB) ( 1010 )   Save

    Perlecan, an important basement-membrane-component, is a large heparan sulfate proteoglycan involved in growth factor sequestration and delivery, thereby enhancing cell adhesion, proliferation, and differentiation. This review aims to discuss the recent progress of perlecan on bone and cartilage development, as well as its function in cell growth, adhesion, and proliferation during bone remodeling.

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    Immunoregulatory effects of natural killer group 2 member D receptor and its ligands on oral tumors
    Wu Lamei, Yang Hongyu.
    Inter J Stomatol. 2013, 40 (5):  695-697.  DOI: 10.7518/gjkq.2013.05.036
    Abstract ( 1281 )   HTML ( 2 )   PDF(pc) (1194KB) ( 754 )   Save

    Oral malignancy, a very common disease with high incidence in humans, poses great threats to human health and life. The activating receptor natural killer group 2 member D(NKG2D) and its ligands play important roles in the immune response to oral tumors by initiating innate immune surveillance and immune clearance at the early stage of tumorigenesis. Two types of ligands have been observed, namely, major histocompatibility complex 1 class-related molecule A and B and UL16-binding protein. Extensive studies on the function of NKG2D and its ligands in oral tumor immunity are helpful in discovering new approaches against oral cancer. This review presents research progress on the immunoregulatory effects of NKG2D receptor and its ligands on oral tumors.

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    Cariogenicity of fluoride-resistant strains of Streptococcus mutans
    Xu Hua, Liu Yingqun.
    Inter J Stomatol. 2013, 40 (5):  698-700.  DOI: 10.7518/gjkq.2013.05.037
    Abstract ( 1396 )   HTML ( 1 )   PDF(pc) (1240KB) ( 941 )   Save

    Long-term application of fluoride results in the generation of fluoride-resistant strains of Streptococcus mutans. Several studies have been conducted worldwide to confirm whether or not changes in cariogenic ability are induced by this mutation and investigate the effectiveness of various fluoride methods in preventing dental caries. This article discusses research progress on the aciduricity, demineralization, acidogenecity, adherence, and glycolytic capacity of fluoride-resistant strains of Streptococcus mutans.

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