Int J Stomatol

Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (5): 691-694.doi: 10.7518/gjkq.2013.05.035

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Function of perlecan in bone regeneration

Wang Yi1, Wang Yanliang2, Hu Rongdang1.   

  1. 1. Dept. of Orthodontics, The Affiliated Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325052, China; 2. Dept. of Oral and Maxillofacial Surgery, The Affiliated Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325052, China
  • Received:2012-08-05 Revised:2013-05-10 Online:2013-09-01 Published:2013-09-01

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Abstract:

Perlecan, an important basement-membrane-component, is a large heparan sulfate proteoglycan involved in growth factor sequestration and delivery, thereby enhancing cell adhesion, proliferation, and differentiation. This review aims to discuss the recent progress of perlecan on bone and cartilage development, as well as its function in cell growth, adhesion, and proliferation during bone remodeling.

Key words: perlecan, heparan sulfate, bone regeneration, tissue engineering


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