Int J Stomatol

Inter J Stomatol ›› 2014, Vol. 41 ›› Issue (2): 199-203.doi: 10.7518/gjkq.2014.02.021

Previous Articles     Next Articles

Effects of platelet-derived growth factor on dental implants

Lei Wenlong1, Shi Bin1,2.   

  1. 1. The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China; 2. Dept. of Implantation, Hospital of Stomatology, Wuhan University, Wuhan 430079, China
  • Received:2013-04-29 Revised:2013-10-15 Online:2014-03-01 Published:2014-03-01

RichHTML

4

PDF (PC)

1126

Abstract:

Bone tissue regeneration engineering involves supplying four basic elements required for bone formation to the defect site, namely, adequate blood supply, bone-forming cells, scaffolds or matrices and signaling molecules, such as growth factors. Platelet-derived growth factor(PDGF) has an important function in organogenesis, development, and trauma healing process, which depend on the binding of the protein tyrosine kinase receptors PDGF receptor-α and β. PDGF is a major mitogen for osteoblasts, fibroblasts, smooth muscle cells, and glial cells. Defects of Pdgf-related genes can lead to skeletal abnormalities, such as fusion of cervical vertebrae and ribs, as well as spina bifida. Following a fracture, platelets aggregate around the fracture site, which releases PDGF into the developing hematoma. in vitro studies have shown that PDGF promotes proliferation and osteogenicdifferentiation of mesenchymal stem cells, osteoblast migration, and fracture healing. Clinical studies show that PDGF can assist in extract socket and ridge augmentation regeneration, peri-implant soft tissue augmentation, and management of peri-implantitis. This paper reviews the effects of rhPDGF-BB on its structure and functions, experiment research in vivo and in vitro, and clinical trials.

Key words: platelet-derived growth factor, dental implant, bone regeneration, alveolar ridge augmentation

CLC Number: 

  • Q 51

TrendMD: 
[1] Chang Xinnan,Liu Lei. Applications and research progress of biodegradable magnesium-based materials in craniomaxillofacial surgery [J]. Int J Stomatol, 2024, 51(1): 107-115.
[2] Han Chong,He Dongning,Yu Feiyan,Wu Dongchao. Research progress on the mechanism and treatment of pain after oral implants [J]. Int J Stomatol, 2024, 51(1): 99-106.
[3] Liao Honglin,Fang Zhonghan,Zhang Yanyan,Liu Fei,Shen Jiefei.. Diagnosis and treatment of post-traumatic trigeminal neuropathic pain after dental implantation [J]. Int J Stomatol, 2023, 50(6): 729-738.
[4] Gong Jiaming,Zhao Ruimin,Pan Hongwei,Lang Xin,Yu Zhanhai,Li Jianxue. Meta-analysis of dynamic navigation versus static navigation in the accuracy of implant surgery [J]. Int J Stomatol, 2023, 50(5): 538-551.
[5] Zhu Keshi,Liao Anqi,Yu Youcheng.. Research progress on the application of machine learning in dental implantology [J]. Int J Stomatol, 2023, 50(4): 491-498.
[6] Xu Yanxue,Fu Li.. Research progress on functionally graded membranes for guided bone regeneration [J]. Int J Stomatol, 2023, 50(3): 353-358.
[7] Lu Qian,Xia Haibin,Wang Min.. Research progress on implantoplasty in the treatment of peri-implantitis [J]. Int J Stomatol, 2023, 50(2): 152-158.
[8] Man Yi, Huang Dingming. Combined treatment strategy of oral implantology and endodontics microsurgery: clinical protocol and practical cases (part 2) [J]. Int J Stomatol, 2022, 49(6): 621-632.
[9] Man Yi, Huang Dingming. Combined treatment strategy of oral implantology and endodontic microsurgery for bone augmentation and en-dodontic diseases in aesthetic area (part 1): application basis and indications [J]. Int J Stomatol, 2022, 49(5): 497-505.
[10] Cai Chaoying,Chen Xuepeng,Hu Ji’an. Research progress on exosome composite scaffolds in oral tissue engineering [J]. Int J Stomatol, 2022, 49(4): 489-496.
[11] Li Yanfei,Zhang Xinchun. Research progress on the dentin bone repair material [J]. Int J Stomatol, 2022, 49(2): 197-203.
[12] Wang Yue,Wen Bing,Deng Mengting,Li Jianping. Research advances of low-level laser therapy on peri-implant tissue healing [J]. Int J Stomatol, 2021, 48(6): 725-730.
[13] Liu Jiacheng,Meng Zhaosong,Li Hongjie,Sui Lei. The role of follistatin in oral and maxillofacial development and its therapeutic application prospect [J]. Int J Stomatol, 2021, 48(5): 556-562.
[14] Zhu Xuanzhi,Zhao Lei. Research progress on the relationship between hypothyroidism and periodontitis [J]. Int J Stomatol, 2021, 48(4): 380-384.
[15] Zhao Wenjun,Chen Yu. Research progress on periodontal functional gradient membrane for guided tissue/bone regeneration [J]. Int J Stomatol, 2021, 48(4): 391-397.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[9] . [J]. Foreign Med Sci: Stomatol, 2004, 31(02): 126 -128 .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .