Int J Stomatol

Int J Stomatol ›› 2019, Vol. 46 ›› Issue (5): 558-564.doi: 10.7518/gjkq.2019078

• Reviews • Previous Articles     Next Articles

Prevention and treatment strategy for oral mucositis by chemoradiotherapy in patients with nasopharyngeal carcinoma

Wei Binbin1,Xiao Miao1,Sun Zhe2,Yi Yuli1()   

  1. 1. Nursing School of Nanchang University, Nanchang 330006, China
    2. Dept. of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China
  • Received:2018-10-12 Revised:2019-04-05 Online:2019-09-01 Published:2019-09-10
  • Contact: Yuli Yi E-mail:Sunyi2628@163.com
  • Supported by:
    This study was supported by Key Research and Development Project of Jiangxi Province(20161BBG70069)

RichHTML

10

PDF (PC)

221

Abstract:

Nasopharyngeal carcinoma, the most common malignant tumor of the head and neck, is prevalent in Guangdong, Guangxi, Hunan, Jiangxi and Fujian provinces (autonomous region) in China, and oral mucositis induced by chemoradiotherapy is frequent. This paper reviews the current situation, etiology and pathogenesis of oral mucositis in patients with nasopharyngeal carcinoma and advances in preventive measure, such as preventive intervention, medication intervention, dietary intervention, psychological intervention and rehabilitation exercise, aiming to provide suggestions for clinical practice.

Key words: nasopharyngeal carcinoma, oral mucositis, prevention, treatment

CLC Number: 

  • R781.5

TrendMD: 
[1] Chua MLK, Wee JTS, Hui EP , et al. Nasopharyngeal carcinoma[J]. Lancet, 2016,387(10022):1012-1024.
[2] Zhu XX, Yang XJ, Chao YL , et al. The potential effect of oral microbiota in the prediction of mucositis during radiotherapy for nasopharyngeal carcinoma[J]. EBioMedicine, 2017,18:23-31.
[3] Wang Y. Evidence-based clinical practice on the interventions for oral mucositis for patients with can- cer receiving treatment [C]. 23rd International Nursing Research Congress, Brisbane, Australia, 30 July- 3 August, 2012.
[4] Panahi Y, Saadat A, Shadboorestan A , et al. An updated review of natural products intended to prevent or treat oral mucositis in patients undergoing radio-chemotherapy[J]. Curr Pharm Biotechnol, 2016,17(11):949-961.
[5] Tao Z, Gao J, Qian L , et al. Factors associated with acute oral mucosal reaction induced by radiotherapy in head and neck squamous cell carcinoma: a retrospective single-center experience[J]. Medicine (Baltimore), 2017,96(50):e8446.
[6] Moslemi D, Nokhandani AM, Otaghsaraei MT , et al. Management of chemo/radiation-induced oral mucositis in patients with head and neck cancer: a review of the current literature[J]. Radiother Oncol, 2016,120(1):13-20.
[7] 陈佩娟, 苏艳, 杜真真 , 等. 中晚期鼻咽癌患者调强放疗联合化疗不良反应分析及预防护理对策[J]. 护理学报, 2014,21(2):34-37.
Chen PJ, Su Y, Du ZZ , et al. Analysis of the adverse reaction and preventive nursing measures of intensity modulated radiotherapy combined with chemotherapy in patients with advanced nasopharyngeal carcinoma[J]. J Nurs, 2014,21(2):34-37.
[8] Riley P, Glenny AM, Worthington HV , et al. Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy[J]. Cochrane Database Syst Rev, 2015, 12: CD011552.
[9] Almståhl A, Finizia C, Carlén A , et al. Mucosal microflora in head and neck cancer patients[J]. Int J Dent Hyg, 2018,16(4):459-466.
[10] Hou J, Zheng H, Li P , et al. Distinct shifts in the oral microbiota are associated with the progression and aggravation of mucositis during radiotherapy[J]. Radiother Oncol, 2018,129(1):44-51.
[11] Li K, Yang L, Xin P , et al. Impact of dose volume parameters and clinical factors on acute radiation oral mucositis for locally advanced nasopharyngeal carcinoma patients treated with concurrent intensity-modulated radiation therapy and chemoradiotherapy[J]. Oral Oncol, 2017,72:32-37.
[12] Lalla RV, Bowen J, Barasch A , et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy[J]. Cancer, 2014,120(10):1453-1461.
[13] Wu SX, Cui TT, Zhao C , et al. A prospective, randomized, multi-center trial to investigate actovegin in prevention and treatment of acute oral mucositis caused by chemoradiotherapy for nasopharyngeal carcinoma[J]. Radiother Oncol, 2010,97(1):113-118.
[14] Daugėlaitė G, Užkuraitytė K, Jagelavičienė E , et al. Prevention and treatment of chemotherapy and radiotherapy induced oral mucositis[J]. Medicina (Kau- nas), 2019,55(2). doi: 10.3390/medicina55020025.
[15] Mallick S, Benson R, Rath GK . Radiation induced oral mucositis: a review of current literature on prevention and management[J]. Eur Arch Otorhinolaryngol, 2016,273(9):2285-2293.
[16] Kanuga S . Cryotherapy and keratinocyte growth factor may be beneficial in preventing oral mucositis in patients with cancer, and sucralfate is effective in reducing its severity[J]. J Am Dent Assoc, 2013,144(8):928-929.
[17] Manzi Nde M , Silveira RC, dos Reis PE. Prophylaxis for mucositis induced by ambulatory chemotherapy: systematic review[J]. J Adv Nurs, 2016,72(4):735-746.
[18] 李小琴, 黄菊红, 许丽媚 . 口含生理盐水冰块对鼻咽癌放疗患者口腔黏膜的影响[J]. 齐鲁护理杂志, 2017,23(11):35-37.
Li XQ, Huang JH, Xu LM . Effects of oral saline ice on oral mucosa of radiotherapy patients with nasopharyngeal carcinoma[J]. J Qilu Nurs, 2017,23(11):35-37.
[19] 顾月 . 口含药物冰块对鼻咽癌放疗患者放射性口腔黏膜炎发生率的影响[D]. 郑州: 郑州大学, 2016.
Gu Y . Effects of oral ice on the incidence of oral mucositis induced by radiotherapy for patients with nasopharyngeal carcinoma[D]. Zhengzhou: Zheng-zhou University, 2016.
[20] Antunes HS, Herchenhorn D, Small IA , et al. Phase Ⅲ trial of low-level laser therapy to prevent oral mucositis in head and neck cancer patients treated with concurrent chemoradiation[J]. Radiother Oncol, 2013,109(2):297-302.
[21] Antunes HS, Schluckebier LF, Herchenhorn D , et al. Cost-effectiveness of low-level laser therapy (LLLT) in head and neck cancer patients receiving concurrent chemoradiation[J]. Oral Oncol, 2016,52:85-90.
[22] 唐世芳, 朱蓉, 宋瑰琦 , 等. 氦氖激光对放射性口腔黏膜反应及其所致疼痛的作用[J]. 广东医学, 2014,35(7):1056-1058.
Tang SF, Zhu R, Song GQ , et al. Effects of He-Ne laser on oral mucosa reaction and pain induced by radiation[J]. Guangdong Med J, 2014,35(7):1056-1058.
[23] Simões A, Benites BM, Benassi C , et al. Antimicrobial photodynamic therapy on treatment of infected radiation-induced oral mucositis: report of two cases[J]. Photodiagnosis Photodyn Ther, 2017,20:18-20.
[24] Hong JP, Lee SW, Song SY , et al. Recombinant human epidermal growth factor treatment of radiation-induced severe oral mucositis in patients with head and neck malignancies[J]. Eur J Cancer Care (Engl), 2009,18(6):636-641.
[25] Riley P, Glenny AM, Worthington HV , et al. Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors[J]. Cochrane Database Syst Rev, 2017, 11: CD011990.
[26] Liang G, Du W, Ke Q , et al. The effects of recombinant human granulocyte colony-stimulating factor mouthwash on radiotherapy-induced oral mucositis in locally advanced nasopharyngeal carcinoma patients[J]. Adv Clin Exp Med, 2017,26(3):409-413.
[27] Guo SP, Wu SG, Zhou J , et al. Transdermal fentanyl for pain due to chemoradiotherapy-induced oral mucositis in nasopharyngeal cancer patients: evaluating efficacy, safety, and improvement in quality of life[J]. Drug Des Devel Ther, 2014,8:497-503.
[28] Charbaji N, Rosenthal P, Schäfer-Korting M , et al. Cytoprotective effects of opioids on irradiated oral epithelial cells[J]. Wound Repair Regen, 2013,21(6):883-889.
[29] Vayne-Bossert P , Escher M, de Vautibault CG, et al. Effect of topical morphine (mouthwash) on oral pain due to chemotherapy- and/or radiotherapy-induced mucositis: a randomized double-blinded study[J]. J Palliat Med, 2010,13(2):125-128.
[30] Cerchietti LC, Navigante AH, Bonomi MR , et al. Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma[J]. Cancer, 2002,95(10):2230-2236.
[31] Zheng B, Zhu X, Liu M , et al. Randomized, double-blind, placebo-controlled trial of Shuanghua Baihe tablets to prevent oral mucositis in patients with nasopharyngeal cancer undergoing chemoradiation therapy[J]. Int J Radiat Oncol Biol Phys, 2018,100(2):418-426.
[32] Luo Y, Feng M, Fan Z , et al. Effect of Kangfuxin solution on chemo/radiotherapy-induced mucositis in nasopharyngeal carcinoma patients: a multicenter, prospective randomized phase Ⅲ clinical study[J]. Evid Based Complement Alternat Med, 2016,2016:8692343.
[33] Bressan V, Stevanin S, Bianchi M , et al. The effects of swallowing disorders, dysgeusia, oral mucositis and xerostomia on nutritional status, oral intake and weight loss in head and neck cancer patients: a systematic review[J]. Cancer Treat Rev, 2016,45:105-119.
[34] Jin T, Li KX, Li PJ , et al. An evaluation of nutrition intervention during radiation therapy in patients with locoregionally advanced nasopharyngeal carcinoma[J]. Oncotarget, 2017,8(48):83723-83733.
[35] Zahn KL, Wong G, Bedrick EJ , et al. Relationship of protein and calorie intake to the severity of oral mucositis in patients with head and neck cancer receiving radiation therapy[J]. Head Neck, 2012,34(5):655-662.
[36] Li G, Jiang XY, Qiu B , et al. Vicious circle of acute radiation toxicities and weight loss predicts poor prognosis for nasopharyngeal carcinoma patients receiving intensity modulated radiotherapy[J]. J Cancer, 2017,8(5):832-838.
[37] 高玉英, 林忠尼, 伍碧琦 . 一位拒绝治疗鼻咽癌末期患者之加护护理经验[J]. 护理杂志, 2009,56(1):96-102.
Kao YY, Lin JN, Wu PC . Caring for a terminal patient with nasopharyngeal carcinoma in the ICU who refuses treatment: a nurse’s experience[J]. J Nurs, 2009,56(1):96-102.
[38] Lai YH, Chang JT, Keefe FJ , et al. Symptom distress, catastrophic thinking, and hope in nasopharyngeal carcinoma patients[J]. Cancer Nurs, 2003,26(6):485-493.
[39] 何爱莲, 惠晓颖, 曹丽 . 自我效能理论在放射性口腔黏膜炎中的应用[J]. 河南医学研究, 2014,23(8):151-153.
He AL, Hui XY, Cao L . Application of self-efficacy theory in radiation-induced oral mucositis[J]. Henan Med Res, 2014,23(8):151-153.
[40] Wang F, Sun Q, Jiang C , et al. Additional induction chemotherapy to concurrent chemotherapy and intensity-modulated radiotherapy with or without nimotuzumab in first-line treatment for locoregionally advanced nasopharyngeal carcinoma: a propensity score matched analysis[J]. J Cancer, 2018,9(3):594-603.
[41] 都孟雅, 陈佩娟 . 头颈部功能锻炼加软木塞法对鼻咽癌病人放疗后生活质量的影响[J]. 护理研究, 2017,31(12):1495-1497.
Du MY, Chen PJ . Influence of head and neck functional exercise combined with cork on quality of life in patients with nasopharyngeal carcinoma after radiotherapy[J]. Nurs Res, 2017,31(12):1495-1497.
[42] 陈静, 马双, 龚伯雄 , 等. 运动锻炼对鼻咽癌患者生活质量的影响[J]. 实用临床医药杂志, 2018,22(6):44-46.
Chen J, Ma S, Gong BX , et al. Effect of exercise training on quality of life of patients with nasopharyngeal carcinoma[J]. J Clin Med Prac, 2018,22(6):44-46.
[43] Araújo SN , Luz MH, da Silva GR, et al. Cancer patients with oral mucositis: challenges for nursing care[J]. Rev Lat Am Enfermagem, 2015,23(2):267-274.
[1] He Zimu, Li Fenglan. Present application of digital oral positioning stents in radiotherapy of head and neck tumor [J]. Int J Stomatol, 2024, 51(1): 28-35.
[2] Wang Nannan,He Hong,Hua Fang. Research progress on the risk factors of orthodontically induced enamel demineralization [J]. Int J Stomatol, 2024, 51(1): 91-98.
[3] Han Chong,He Dongning,Yu Feiyan,Wu Dongchao. Research progress on the mechanism and treatment of pain after oral implants [J]. Int J Stomatol, 2024, 51(1): 99-106.
[4] Sun Xu,Deng Zhennan,Wen Cai,Zhao Ying. Implant surface micromorphological changes after Er: YAG laser irradiation observed under scanning electron microscope [J]. Int J Stomatol, 2023, 50(6): 669-673.
[5] Huang Yuanhong,Peng Xian,Zhou Xuedong.. Progress in research into the effect of Rhizoma Drynariae on the treatment of bone-related diseases in the oral cavity [J]. Int J Stomatol, 2023, 50(6): 679-685.
[6] Liu Yang,Yin Deqiang. Introducing a novel digital articulation workflow with high precision [J]. Int J Stomatol, 2023, 50(5): 499-505.
[7] Ji Xiao,Zhang Lan,Huang Dingming.. Diagnosis and treatment of odontogenic and non-odontogenic maxillary sinusitis [J]. Int J Stomatol, 2023, 50(5): 566-572.
[8] Zhao Yuanxi,Su Qin.. Application and development of supplementary techniques in removing the remaining filling materials of root canal retreatment [J]. Int J Stomatol, 2023, 50(5): 581-586.
[9] Gong Meiling,Cheng Xingqun,Wu Hongkun.. Research progress on the correlation between Parkinson’s disease and periodontitis [J]. Int J Stomatol, 2023, 50(5): 587-593.
[10] Liu Ting,Wu Xiuping.. Research progress on oral-craniomaxillofacial features and treatment of Down syndrome [J]. Int J Stomatol, 2023, 50(5): 618-622.
[11] Chen Yifei,Zhang Binjing,Feng Shuqi,Xu Rui,Yang Shuxian,Li Yuqing. Effects of flavonoids on oral microorganisms and its mechanism [J]. Int J Stomatol, 2023, 50(2): 210-216.
[12] Qin Yichun,Tan Xuelian,Huang Dingming.. Clinical research progress on glandular odontogenic cyst [J]. Int J Stomatol, 2023, 50(1): 100-107.
[13] Li Ting,Yang Xuecai,Wang Junwei.. Children with Williams-Beuren syndrome associated with cranial and maxillofacial deformity [J]. Int J Stomatol, 2023, 50(1): 108-113.
[14] Yang Mingyan,Zhang Fan,Zhao Lei. Research progress on oral flora changes affecting the course of radiotherapy and chemotherapy-related oral mucositis [J]. Int J Stomatol, 2023, 50(1): 43-51.
[15] Chen Xiaoli,Zhang Fan,Liu Chengcheng. Application progress on photobiomodulation in the prevention and treatment of oral complications after radiothe-rapy [J]. Int J Stomatol, 2022, 49(6): 707-716.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .