Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (6): 646-651.doi: 10.7518/gjkq.2018.06.005

• RNA Research • Previous Articles     Next Articles

Investigative progresses of microRNA in oral squamous cell carcinoma

Chuan Fang,Yadong Li()   

  1. Dept. of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 630014, China
  • Received:2017-11-20 Revised:2018-06-11 Online:2018-11-01 Published:2018-11-15
  • Contact: Yadong Li E-mail:llxxyydd2006@sina.com
  • Supported by:
    This study was supported by Training Program for Medical Supreme Reserve Talents of Chongqing National Health and Family Planning Commission(2017HBRC004)

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Abstract:

MicroRNAs (miRNAs) are a series of noncoding single-stranded RNA molecules encoded by endogenous genes that affect post-transcriptional gene regulation. Aberrant expression of miRNA involved in oral squamous cell carcinomas is related to tumour growth, cellular apoptosis, invasion, metastasis, radiosensitivity and chemosensitivity. Such aberrant expression regulates target genes or signalling pathways and can potentially be applied to clinic as a kind of biomarker in early diagnosis and prognosis. Accordingly, this review generalizes the association between ectopic miRNA and oral squamous cell carcinoma. Simultaneously, it summarizes the axis, namely, miRNA-target gene/downstream-signaling pathway-tumorous effect, and forecasts the prospect of clinical application.

Key words: oral squamous cell carcinoma, microRNA, target gene, signaling pathway

CLC Number: 

  • R739.8

TrendMD: 

Fig 1

Biogenisis process of microRNA"

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