Int J Stomatol

Int J Stomatol ›› 2022, Vol. 49 ›› Issue (3): 349-355.doi: 10.7518/gjkq.2022051

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Differential expression of microRNA in gingival crevicular fluid of periodontitis and its regulatory mechanism on periodontitis

Qian Suting(),Ding Lingmin,Ji Yaning,Lin Jun.()   

  1. Dept. of Stomatology, The First Affiliated Hospital, Zhe-jiang University School of Medicine, Hangzhou 310003, China
  • Received:2021-07-06 Revised:2021-12-21 Online:2022-05-01 Published:2022-05-09
  • Contact: Jun. Lin E-mail:1176917636@qq.com;junlin2@126.com
  • Supported by:
    National Natural Science Foundation of China(81970978)

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Abstract:

Periodontitis is an inflammatory disease characterised by the formation of periodontal pocket and the resorption of alveolar bone. It is the main cause of tooth loss in adults over 40 years old. The gingival crevicular fluid produced by the periodontal tissue can reflect the state of periodontal inflammation to a certain extent, and the expression level of microRNA (miRNA) in it changes according to the progression of periodontal inflammation, which can be used as an indicator of periodontal diagnosis. The expression levels of miR-146a and miR-223 can be altered significantly during perio-dontitis progression. They are currently the most potential biomarkers periodontitis diagnosis by using miRNA in gingival crevicular fluid. Different miRNAs can play different roles by regulating the different stages of the periodontitis signalling pathway, such as the binding of bacterial lipopolysaccharide and Toll-like receptor, nuclear factor-κB ligand signalling pathway, and the release of inflammatory factors. This review elaborates the expression differences and modulation mechanisms of miRNA in periodontitis gingival crevicular fluid with a view to offer novel insights and strategies for the accurate diagnosis of periodontitis by miRNA in gingival crevicular fluid.

Key words: gingival crevicular fluid, microRNA, periodontitis, Toll-like receptor, nuclear factor-κB ligand

CLC Number: 

  • R 781.4

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Fig 1

miRNA signaling pathway in periodontitis modulation"

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