Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (4): 433-438.doi: 10.7518/gjkq.2018.04.011

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Progress in the interactive mechanism between Enterococcus faecalis and macrophages

Lin Dongjia, Peng Zhixiang, Gao Yan.   

  1. Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2017-12-06 Revised:2018-04-17 Online:2018-07-02 Published:2018-07-02
  • Supported by:
    This study was supported by Guangdong Provincial Natural Science Foundation (2016A030313267).

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Abstract: Enterococcus faecalis is the main pathogen of refractory apical periodontitis. Lipoteichoic acid is the main immunogen and an important virulence factor of such infection. Macrophages, which are an important member of the natural immune response, are crucial in phagocytosis of microbes, presentation of antigens and secretion of various cytokines to regulate the inflammatory response of the body. In the long-term interaction with the host macrophages, E. faecalis gradually forms a variety of effective strategies for survival and proliferation. This review focuses on the resistance of macrophages to E. faecalis and the strategies of E. faecalis to avoid killing macrophages.

Key words: Enterococcus faecalis, macrophages, periodontitis

CLC Number: 

  • R780.2

TrendMD: 
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