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Table of Content

    02 July 2018, Volume 45 Issue 4 Previous Issue    Next Issue
    Expert Forum
    Re-discuss the approaches to microform cleft lip repair
    Shi Bing
    Inter J Stomatol. 2018, 45 (4):  373-377.  DOI: 10.7518/gjkq.2018.04.001
    Abstract ( 1228 )   HTML ( 69 )   PDF(pc) (59572KB) ( 266 )   Save

    To meet the ever demanding rehabilitation standards set by parents of children with microform cleft lip anomalies, the author has been making persistent efforts in improving the surgical outcomes. Basing on understanding of the development mechanism of microform cleft lip, and the advantages and disadvantages of previous surgical techniques, new reconstructive technique was developed and introduced in details here. The cutaneous deformity would be the focus for the future efforts in microform cleft lip repair. Insatiable demands from parents of children with clefts would be the essential impetus for the advancement of cleft repair.

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    Discussions
    Timing and indication of surgical intervention for submucous cleft palate patients
    Yin Heng, Yu Tianxiang, Jiang Liping, Jiang Chenghui, Shi Bing, Chen Renji
    Inter J Stomatol. 2018, 45 (4):  378-383.  DOI: 10.7518/gjkq.2018.04.002
    Abstract ( 1382 )   HTML ( 17 )   PDF(pc) (2096KB) ( 549 )   Save
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    Approaching nasolabial deformities secondary to cleft lip
    Li Jingtao, Zhou Lian, Zhang Junrui, Cai Ming, Li Jian
    Inter J Stomatol. 2018, 45 (4):  384-390.  DOI: 10.7518/gjkq.2018.04.003
    Abstract ( 533 )   HTML ( 10 )   PDF(pc) (5660KB) ( 453 )   Save
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    Original Articles
    Level of N-α-acetyltransferase 10 in saliva and serum of patients with oral squamous cell carcinoma and its clinical significance
    Yu Xinle, Zheng Jun, Xu Jiang, Zeng Yan
    Inter J Stomatol. 2018, 45 (4):  391-395.  DOI: 10.7518/gjkq.2018.04.004
    Abstract ( 924 )   HTML ( 11 )   PDF(pc) (1306KB) ( 194 )   Save

    Objective To detect the level of N-α-acetyltransferase 10 (Naa10) in the saliva and serum of patients with oral squamous cell carcinoma (OSCC) and normal adults, and to explore its clinical significance.Methods Using enzyme-linked immunosorbent assay (ELISA) to detect the levels of Naa10 in the serum and saliva of OSCC patients and normal adults, the correlation between the level of Naa10 and age, gender, nationality, histological grade, clinical stage and tumor metastasis were analyzed. To evaluate the value of salivary and serum Naa10 in the diagnosis of OSCC by receiver operating characteristic (ROC) curve.Results The levels of Naa10 in saliva and serum of patients with OSCC were higher than those in normal controls. In both patients with OSCC and normal controls, salivary Naa10 was higher than serum Naa10. Level of Naa10 in serum was correlated with the age of OSCC patients (P<0.05). Level of Naa10 in saliva was correlated with the histological grade of OSCC patients (P<0.05). But there was no statistical difference between the other pathological parameters and Naa10 levels in saliva and serum. The area under the ROC curve of Naa10 in saliva and serum was 0.924 and 0.713. In saliva and serum, the sensitivity, specificity and accuracy of Naa10 were 85.4%, 85.0%, 85.3% and 74.2%, 65.0%, 72.1%.Conclusion Detection of Naa10 levels in saliva and serum is useful in diagnosis of OSCC, and its sensitivity and specificity in saliva are better than those in serum. The level of Naa10 in saliva is related to the degree of differentiation, which may help to determine the degree of malignancy of OSCC.

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    Changes on periodontal index and inflammatory factor levels in gingival crevicular fluid after implant restoration in patients with chronic periodontitis
    Huang Haixia, Lan Yuyan, Zhang Hao, Pan Lanlan, Guo Ling, Liu Min
    Inter J Stomatol. 2018, 45 (4):  396-402.  DOI: 10.7518/gjkq.2018.04.005
    Abstract ( 885 )   HTML ( 15 )   PDF(pc) (1269KB) ( 321 )   Save
    Objective This work aims to determine the changes in periodontal index and inflammatory factor levels in gingival crevicular fluid after implant restoration in patients with chronic periodontitis.Methods A total of 40 patients with tooth-loss in chronic periodontitis and healthy periodontium were selected as the research and control groups, respectively, and were treated with implant restoration from June 2015 to June 2017. Probing depth (PD), modification plaque index (mPLI), papilla index score (PIS), modification sulcus bleeding index (mSBI) and marginal bone loss volume were detected and compared at 1, 3, and 6 months after implant restoration between the two groups. The interleukin (IL)-1β, IL-6, and IL-8 levels in gingival crevicular fluid of two groups were detected and compared.Results The implant survival rate after implant restoration for the two groups were both 100%. Three months after implant restoration, IL-1β, IL-6, and IL-8 levels in the research group were significantly increased as opposed to the levels 1 month after implant restoration; and the mentioned levels in the research group are also higher than that of 3 months after implant restoration in control group (P<0.05, P<0.01). Six months after implant restoration, the PD, mPLI, mSBI and marginal bone loss volume for the research group increased compared with that at 1 month after implant restoration; the mentioned results in the research group are significantly higher than that of 6 months after implant restoration in control group (P<0.05, P<0.01). The PIS of the two groups showed no statistically significance (P>0.05).Conclusion The short-term effect of implant restoration in chronic periodontitis patients is ideal, but the risk of peri-implantitis is higher on patients with healthy periodontium compared with the other group.
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    An investigation of parents’ knowledge-attitude-practice of early preventive and treatment for malocclusions
    Zhang Wenqi, Wang Hong, Han Yu, Yang Shuangyan, Wang Ruifang, Wang Chunling
    Inter J Stomatol. 2018, 45 (4):  403-407.  DOI: 10.7518/gjkq.2018.04.006
    Abstract ( 773 )   HTML ( 9 )   PDF(pc) (1272KB) ( 728 )   Save

    Objective To investigate parents’ knowledge-attitudes-practice (KAP) of early preventive and treatment for malocclusions and analyze its influencing factors, further to provide theoretical basis for early prevention and treatment of health education and guide people to participate in early prevention and treatment.Methods By convenient sampling method, parents in Stomatological Hospital of Shandong University were selected and surveyed using KAP questionnaire.Results A total of 520 questionnaires were distributed, and 490 valid questionnaires were collected. The participants had an average score of 14.68±8.21 in knowledge, 29.97±6.45 in attitude, and 32.16±7.04 in practice. Multiple regression analysis showed that the account type and education level had an effect on the scores of knowledge. The type of account type had an effect on the scores of parents’ beliefs. Father or mother, whether parents received orthodontic treatment affect parents’ behavior score.Conclusion Parents have inadequate knowledge in early prevention and treatment of malocclusion and were poor in the attitudes and behavior. Therefore, it is necessary to strengthen the early prevention and treatment propaganda work in children’s parents so as to improve the children’s oral health.

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    Reviews
    Research development of silver nanoparticle on prevention and treatment of oral infectious disease
    Liu Dan, Ren Biao, Cheng Lei.
    Inter J Stomatol. 2018, 45 (4):  408-413.  DOI: 10.7518/gjkq.2018.04.007
    Abstract ( 689 )   HTML ( 11 )   PDF(pc) (1200KB) ( 265 )   Save
    Silver nanoparticle is a novel antibacterial agent produced by nanotechnology research. This nanoparticle is widely used in various fields for its remarkable antibacterial effect compared with those of traditional inorganic antibacterial agents. Silver nanoparticle also presents considerable safety, lasting efficacy and a long-term antimicrobial effect. In this review, we mainly describe the antibacterial mechanism and characteristics of silver nanoparticles and related research on the prevention of infectious microbial diseases and treatment of oral cavity.
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    Preparation and biomedical applications of alginate-chitosan microspheres
    Jin Xin, Yang Junxing, Wang Yingnan, Liu Zhihui, Wang Bowei
    Inter J Stomatol. 2018, 45 (4):  414-419.  DOI: 10.7518/gjkq.2018.04.008
    Abstract ( 889 )   HTML ( 14 )   PDF(pc) (1399KB) ( 652 )   Save
    Chitosan is the only natural alkaline amino polysaccharide, and alginate is a kind of natural anionic polysac-charide. These polysaccharides are good materials for microsphere preparation because of their good biocompatibility, nontoxicity and biodegradability. This paper reviews the main methods (ion crosslinking and emulsification) of microsphere preparation by using the combination of chitosan and alginate and its application as a drug carrier in biomedicine.
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    Research progress on non-coding RNAs in tongue squamous cell carcinoma
    Wang Liping, Zha Jun, Ge Linhu.
    Inter J Stomatol. 2018, 45 (4):  420-424.  DOI: 10.7518/gjkq.2018.04.009
    Abstract ( 738 )   HTML ( 3 )   PDF(pc) (1279KB) ( 313 )   Save
    As the development of genomics and transcriptomics, non-coding RNAs (ncRNAs) have been paid much attention. Previous studies have suggested that ncRNAs could regulate gene expression through several biological processes such as chromosome remodeling, transcription, and posttranscription translation. Abnormal versions of ncRNAs are closely related to several human diseases such as the generation and development of tumors. Therefore, ncRNAs may become novel biomarkers in the diagnosis, prognosis and target therapies of tumor research. As the essential role of ncRNAs playing in tongue squamous cell carcinoma (TSCC), the latest domestic and foreign literatures in TSCC progression were reviewed in this article.
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    Long non-coding RNA and its relationship with oral cancer
    Song Hongning, Wang Xuxia, Zhang Jun
    Inter J Stomatol. 2018, 45 (4):  425-432.  DOI: 10.7518/gjkq.2018.04.010
    Abstract ( 491 )   HTML ( 3 )   PDF(pc) (1319KB) ( 612 )   Save
    Long non-coding RNA (lncRNA) is a family of non-protein-coding RNAs with length of more than 200 nucleotides. These lncRNAs have gained considerable attention and recently emerged as main participants in biological processes. An increasing number of studies showed that lncRNAs play important roles in diverse cellular processes, including proliferation, differentiation, apoptosis, migration, invasion and chromatin remodelling. Importantly, lncRNAs are increasingly recognised in cancer biology and prognosis. Multiple studies also indicated that lncRNAs play important roles in tumour growth and metastasis and poor prognosis in multiple tumour types. These RNAs may also act as a potential biomarker and therapeutic target for human cancers. Furthermore, lncRNA deregulation is observed in multiple tumours. However, the molecular mechanism of lncRNAs in cancer initiation, progression and metastasis remains poorly understood. In this review, we highlight the recent findings on lncRNAs in cancer pathogenesis and summarise an overview of current knowledge concerning the expression and role of lncRNA in various cancers. Additionally, lncRNAs emerged as a new class of promising cancer biomarkers. Independent studies demonstrated the feasibility of their use as tools in the diagnosis and prognosis of different types of malignancies and in the prediction and possible monitoring treatment response. The role of lncRNAs in cancers is an emerging field of study. Although our understanding about the role of lncRNAs in the onset and progression of cancers is still in its infancy, further understanding the activities of lncRNAs will secure improved treatment options for cancer patients.
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    Progress in the interactive mechanism between Enterococcus faecalis and macrophages
    Lin Dongjia, Peng Zhixiang, Gao Yan.
    Inter J Stomatol. 2018, 45 (4):  433-438.  DOI: 10.7518/gjkq.2018.04.011
    Abstract ( 752 )   HTML ( 11 )   PDF(pc) (1271KB) ( 543 )   Save
    Enterococcus faecalis is the main pathogen of refractory apical periodontitis. Lipoteichoic acid is the main immunogen and an important virulence factor of such infection. Macrophages, which are an important member of the natural immune response, are crucial in phagocytosis of microbes, presentation of antigens and secretion of various cytokines to regulate the inflammatory response of the body. In the long-term interaction with the host macrophages, E. faecalis gradually forms a variety of effective strategies for survival and proliferation. This review focuses on the resistance of macrophages to E. faecalis and the strategies of E. faecalis to avoid killing macrophages.
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    Factors influencing the clearance efficiency of root canal disinfectant calcium hydroxide
    Jia Zhuoqun, Yang Lu.
    Inter J Stomatol. 2018, 45 (4):  439-443.  DOI: 10.7518/gjkq.2018.04.012
    Abstract ( 840 )   HTML ( 32 )   PDF(pc) (1240KB) ( 623 )   Save
    Calcium hydroxide is the most commonly used disinfectant in clinical medicine. The success rate of root canal therapy can be reduced by the residual calcium hydroxide. The removal efficiency of calcium hydroxide in root canal was reviewed in the following aspects: anatomy of root canal, application of different irrigation equipment and irrigation solution.
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    Research progress on macrophage in bone tissue repair
    Zhu Chenyou, Wei Shimin, Wang Yuanjing, Wu Yingying.
    Inter J Stomatol. 2018, 45 (4):  444-448.  DOI: 10.7518/gjkq.2018.04.013
    Abstract ( 1188 )   HTML ( 35 )   PDF(pc) (1198KB) ( 977 )   Save
    The immune system is an important barrier for defense in the human body. This system includes B cells, T cells, dendritic cells (DC), and macrophages, which play a pivotal role in tissue injury, tumor, and bone remodeling. The understanding of macrophages has improved in the past years, but numerous mechanisms between macrophages and biomaterials remain largely unknown. Thus, the present study discusses the response between macrophages and biomaterials and predicts their potential application to provide new ideas for basic and clinical research.
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    Clinical characteristics and the diagnosis and treatment of non-syndromic supernumerary teeth
    Fang Hui, Yang Jie
    Inter J Stomatol. 2018, 45 (4):  449-454.  DOI: 10.7518/gjkq.2018.04.014
    Abstract ( 730 )   HTML ( 8 )   PDF(pc) (1165KB) ( 277 )   Save
    Supernumerary teeth, also known as extra teeth, clinically manifest as in excess of the usual configuration of the normal number of teeth. These are associated with certain systemic diseases and syndromes. The general characteristics, etiology, influence, diagnosis, and treatment timing of non-syndromic supernumerary teeth were reviewed in this article with the aim of providing certain instructions and pieces of evidence for clinical work.
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    Research progress on the mechanical and antibacterial properties of nanomaterial-modified denture base
    Zeng Yue, Xia Haibin, Wang Min
    Inter J Stomatol. 2018, 45 (4):  455-458.  DOI: 10.7518/gjkq.2018.04.015
    Abstract ( 732 )   HTML ( 7 )   PDF(pc) (1220KB) ( 299 )   Save
    The mechanical properties and antibacterial properties of the resin denture base should be improved given that the denture base is prone to fracture and bacterial adhesion may lead to mucositis and caries. In this paper, the mechanical properties and antibacterial properties of denture bases modified with nanomaterials were reviewed.
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    Research progress on the biological properties of calcium silicate-based pulp capping agents
    Chen Yanhuo, An Shaofeng, Gao Yan
    Inter J Stomatol. 2018, 45 (4):  459-464.  DOI: 10.7518/gjkq.2018.04.016
    Abstract ( 958 )   HTML ( 17 )   PDF(pc) (1265KB) ( 597 )   Save
    With the progress of the dental pulp biology and biomaterials research, minimally invasive clinical approach including vital pulp therapy has become a hot spot in endodontics. Biological properties of pulp capping agent play a pivotal role in determining the events of vital pulp therapy. Calcium silicate cements are biocompatible novel materials with excellent physicochemical properties and capacity for stimulating reparative dentin formation. Currently, different types of calcium silicate cements have been applied to vital pulp therapy and achieved good clinical outcomes. However, there is a great quantity of researches regarding these materials, which may confuse readers. Therefore, the aim of this paper is to review current progress on biological properties and feasible strategies of different calcium silicate-based capping agents in order to provide a reference for their rational clinical application.
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    Research progress on root canal irrigation
    Huang Lidong, Gong Weiyu, Dong Yanmei.
    Inter J Stomatol. 2018, 45 (4):  465-472.  DOI: 10.7518/gjkq.2018.04.017
    Abstract ( 1128 )   HTML ( 87 )   PDF(pc) (1287KB) ( 2930 )   Save
    Root canal irrigation is an indispensable part of root canal preparation. Effective irrigation depends on the continuous development of irrigants and irrigation techniques. Recently, studies in irrigants and techniques have been carried out to improve the effect of irrigation and disinfection. Microorganisms, smear layer and lipopolysaccharide within root canal can be removed at a larger degree by means of improving the performance of irrigants and combined using different irrigants. And with the aid of supplementary methods and new techniques, irrigants can be better delivered and agitated, which induces higher cleaning efficiency in apical third and enhanced effect of chemical preparation in root canal system. This paper reviewed the research progress on root canal irrigants, irrigation methods and techniques.
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    Clinical application of minimally invasive techniques in the management of children’s dental caries
    Ding Jie, Song Guangtai.
    Inter J Stomatol. 2018, 45 (4):  473-479.  DOI: 10.7518/gjkq.2018.04.018
    Abstract ( 705 )   HTML ( 17 )   PDF(pc) (1176KB) ( 802 )   Save
    With the development of “minimally invasive dentistry”, more and more minimally invasive techniques have been applied to manage dental caries of children. This article will review present common techniques for managing dental caries of children in clinical practice.
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    Gorham-Stout syndrome in the maxillofacial region
    Liu Min, Liu Weiwei, Xu Zhimin, Wang Zilin, Li Jiale, Han Bing.
    Inter J Stomatol. 2018, 45 (4):  480-484.  DOI: 10.7518/gjkq.2018.04.019
    Abstract ( 1365 )   HTML ( 17 )   PDF(pc) (1234KB) ( 266 )   Save
    Gorham-Stout syndrome, which is also called massive osteolysis, vanishing bone disease, phantom bone disease, is characterized by spontaneous progressie bone resorption, and is a rare disorder in the clinical, whereas the etiology is unknown. Gorham-Stout syndrome is characterized histologically by the proliferation of endothelial-lined vessels in bone and by the replacement of bone with fibrous tissue. Clinical manifestations are diverse. In most cases, only a single bone or several bones are affected. Associated infiltrative soft tissue abnormality is often found. Reports of maxillofacial bone resorption are few. According to the literature of domestic and overseas, the aim of this paper is to make a brief review about the etiology, clinical manifestations, diagnosis and differential diagnosis and therapy of Gorham-Stout syndrome.
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    Clinical progress of the ankyloglossia
    Huang Chunpeng, Liu Xian, Bao Chongyun
    Inter J Stomatol. 2018, 45 (4):  485-481.  DOI: 10.7518/gjkq.2018.04.020
    Abstract ( 1163 )   HTML ( 50 )   PDF(pc) (1174KB) ( 1317 )   Save
    Ankyloglossia is a common congenital oral disformity. The abnormal of lingual frenulum or speech act as the indication of frenotomy in clinical treatment mostly, but literatures show ankyloglossia isn’t directly related to speech. So, the risk of excessive operation exists if the abnormal of lingual frenulum or speech were applied as the indication of frenotomy. Breastfeeding plays an important role in infant growth, in recent years, ankyloglossia with nipple pain, trauma and even affected growth of infant get more attention with the advocating of breastfeeding. We retrospect researches about the relationship between ankyloglossia and breastfeeding difficulties, pathogenesis, diagnosis and treatment in this review, emphasizing the relationship between the tongue tie and breastfeeding and then sum up the surgical indications of ankyloglossia, it is expected to provide a new guidance standard for clinical work.
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    Oral health promotion and maintenance of mental/intellectual disabled children
    You Wenzhe, Xia Bin.
    Inter J Stomatol. 2018, 45 (4):  492-496.  DOI: 10.7518/gjkq.2018.04.021
    Abstract ( 889 )   HTML ( 8 )   PDF(pc) (1278KB) ( 251 )   Save
    Oral hygiene status of mental/intellectual disabled children has got more and more attention. It’s of great importance to help them to maintain oral health independently. Meanwhile, guardians and oral hygienists should play important roles in it. This review mainly summarized relevant studies on oral health promotion and maintenance of mental/intellectual disabled children, therefore, it could be referred in relevant studies in the future.
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