Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (4): 396-402.doi: 10.7518/gjkq.2018.04.005

• Original Articles • Previous Articles     Next Articles

Changes on periodontal index and inflammatory factor levels in gingival crevicular fluid after implant restoration in patients with chronic periodontitis

Huang Haixia1, Lan Yuyan1, Zhang Hao1, Pan Lanlan2, Guo Ling1, Liu Min1   

  1. 1. Dept. of Prosthodontics, Hospital of Stomatology, Southwest Medical University, Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, Luzhou 646000, China;
    2. Dept. of Periodontology, Stomatological Hospital of Chongqing Medical University, Chongqing 401120, China
  • Received:2017-11-20 Revised:2018-04-13 Online:2018-07-02 Published:2018-07-02
  • Supported by:
    This study was supported by Sichuan Science and Technology Project (LY-51).

Abstract: Objective This work aims to determine the changes in periodontal index and inflammatory factor levels in gingival crevicular fluid after implant restoration in patients with chronic periodontitis.Methods A total of 40 patients with tooth-loss in chronic periodontitis and healthy periodontium were selected as the research and control groups, respectively, and were treated with implant restoration from June 2015 to June 2017. Probing depth (PD), modification plaque index (mPLI), papilla index score (PIS), modification sulcus bleeding index (mSBI) and marginal bone loss volume were detected and compared at 1, 3, and 6 months after implant restoration between the two groups. The interleukin (IL)-1β, IL-6, and IL-8 levels in gingival crevicular fluid of two groups were detected and compared.Results The implant survival rate after implant restoration for the two groups were both 100%. Three months after implant restoration, IL-1β, IL-6, and IL-8 levels in the research group were significantly increased as opposed to the levels 1 month after implant restoration; and the mentioned levels in the research group are also higher than that of 3 months after implant restoration in control group (P<0.05, P<0.01). Six months after implant restoration, the PD, mPLI, mSBI and marginal bone loss volume for the research group increased compared with that at 1 month after implant restoration; the mentioned results in the research group are significantly higher than that of 6 months after implant restoration in control group (P<0.05, P<0.01). The PIS of the two groups showed no statistically significance (P>0.05).Conclusion The short-term effect of implant restoration in chronic periodontitis patients is ideal, but the risk of peri-implantitis is higher on patients with healthy periodontium compared with the other group.

Key words: chronic periodontitis, implant restoration, periodontal index, inflammatory factor, peri-implantitis

CLC Number: 

  • R781.4+2

TrendMD: 
[1] Saglam M, Kantarci A, Dundar N, et al.Clinical and biochemical effects of diode laser as an adjunct to nonsurgical treatment of chronic periodontitis: a randomized, controlled clinical trial[J]. Lasers Med Sci, 2014, 29(1): 37-46.
[2] 董小宇, 徐卿朝, 张新丽, 等. 慢性牙周炎患者种植义齿修复临床疗效评价的meta分析[J]. 口腔医学研究, 2014, 30(12): 1144-1148.Dong XY, Xu QC, Zhang XL, et al.Clinical curative evaluation of implant dentures in periodontitis pa-tients: a meta-analysis[J]. J Oral Sci Res, 2014, 30(12): 1144-1148.
[3] Gurol C, Kazazoglu E, Dabakoglu B, et al.A com-parative study of the role of cytokine polymorphisms interleukin-10 and tumor necrosis factor alpha in susceptibility to implant failure and chronic perio-dontitis[J]. Int J Oral Maxillofac Implants, 2011, 26(5): 955-960.
[4] 王林虎, 施斌, 叶明福, 等. 慢性牙周炎与种植牙相关性的Meta分析[J]. 中华口腔医学研究杂志(电子版), 2014, 8(1): 28-32.Wang LH, Shi B, Ye MF, et al.Correlation between chronic periodontitis and dental implants:a Meta-analysis[J]. Chin J Stomatol Res (Electr Ed), 2014, 8(1): 28-32.
[5] 杨柳青, 徐雪, 王黎明, 等. 慢性牙周炎患者龈沟液中IL-8和TNF-α水平变化及临床意义[J]. 现代生物医学进展, 2016, 16(30): 5933-5936.Yang LQ, Xu X, Wang LM, et al.Changes of IL-8 and TNF-α levels in gingival sulcus fluid of patients with chronic periodontitis and theirs clinical signi-ficance[J]. Prog Modern Biomed, 2016, 16(30): 5933-5936.
[6] Petković-Curcin A, Matić S, Vojvodić D, et al.Cyto-kines in pathogenesis of peri-implantitis[J]. Vojno-sanit Pregl, 2011, 68(5): 435-440.
[7] 黄海霞, 兰玉燕, 潘兰兰, 等. 种植修复后慢性牙周炎患者种植体的松动度、SBI及PIS指数的变化水平[J]. 重庆医学, 2015, 44(28): 3935-3937.Huang HX, Lan YY, Pan LL, et al.Implant mobility, SBI and PIS changes in patients with chronic perio-dontitis after implant treatment[J]. Chongqing Med, 2015, 44(28): 3935-3937.
[8] De Boever AL, Quirynen M, Coucke W, et al.Cli-nical and radiographic study of implant treatment outcome in periodontally susceptible and non-su-sceptible patients: a prospective long-term study[J]. Clin Oral Implants Res, 2009, 20(12): 1341-1350.
[9] 韩仕斌, 王远勤, 左陈启, 等. 牙周炎患者种植义齿修复5年回顾性研究[J]. 广东牙病防治, 2011, 19(8): 423-425.Han SB, Wang YQ, Zuo CQ, et al.Five-year retro-spective analysis of dental implants in patients with periodontitis[J]. J Dent Prev Treat, 2011, 19(8): 423-425.
[10] Heitz-Mayfield LJ, Huynh-Ba G.History of treated periodontitis and smoking as risks for implant the-rapy[J]. Int J Oral Maxillofac Implants, 2009, 24(Suppl): 39-68.
[11] 张艽, 李纲, 杨颖, 等. 牙种植修复在慢性牙周炎患者与牙周健康者的疗效对比分析[J]. 重庆医学, 2013, 42(11): 1245-1247.Zhang J, Li G, Yang Y, et al.The comparative ana-lysis of the effects of dental transplantation for pa-tients with or without chronic periodontitis[J]. Chong-qing Med, 2013, 42(11): 1245-1247.
[12] Ferreira CF, Buttendorf AR, de Souza JG, et al. Prevalence of peri-implant diseases: analyses of associated factors[J]. Eur J Prosthodont Restor Dent, 2015, 23(4): 199-206.
[13] Kim GY, Lee CH.Antimicrobial susceptibility and pathogenic genes of Staphylococcus aureus isolated from the oral cavity of patients with periodontitis[J]. J Periodontal Implant Sci, 2015, 45(6): 223-228.
[14] 宿玉成. 现代口腔种植学[M]. 北京: 人民卫生出版社, 2004: 388-389.Su YC.Contemporary oral implantology[M]. Beijing: People’s Medical Publishing House, 2004: 388-389.
[15] Sgolastra F, Gatto R, Petrucci A, et al.Effectiveness of systemic amoxicillin/metronidazole as adjunctive therapy to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis[J]. J Periodontol, 2012, 83(10): 1257-1269.
[16] 李金超, 马艳, 江欣, 等. 慢性牙周炎患者龈下菌斑对种植体周骨吸收影响的临床研究[J]. 临床和实验医学杂志, 2016, 15(13): 1250-1253.Li JC, Ma Y, Jiang X, et al.The clinical study on the effect of subgingival plaque of patients with chronic periodontitis of implant peri bone resorption[J]. J Clin Exp Med, 2016, 15(13): 1250-1253.
[17] van Steenberghe D, Klinge B, Lindén U, et al. Perio-dontal indices around natural and titanium abutments: a longitudinal multicenter study[J]. J Periodontol, 1993, 64(6): 538-541.
[18] 高少怀, 段海英, 李智勇. 实验性种植体周围炎龈沟液中IL-10和IL-17的分析[J]. 口腔医学研究, 2012, 28(7): 648-650, 655.Gao SH, Duan HY, Li ZY.Analysis of IL-10 and IL-17 in peri-implant sulcular fluid of experimental peri-implantitis[J]. J Oral Sci Res, 2012, 28(7): 648-650, 655.
[19] 刘璐, 张巧红, 朱洪光, 等. 白介素-1β与种植体周围炎的相关性实验研究[J]. 中国口腔种植学杂志, 2013, 18(1): 15-17.Liu L, Zhang QH, Zhu HG, et al.Experiment study on relationship between IL-1β and peri-implantitis[J]. Chin J Oral Implantol, 2013, 18(1): 15-17.
[20] Melo RF, Lopes BM, Shibli JA, et al.Interleukin-1β and interleukin-6 expression and gene polymor-phisms in subjects with peri-implant disease[J]. Clin Implant Dent Relat Res, 2012, 14(6): 905-914.
[21] 赵靓, 曹远. 牙周基础治疗对牙周炎患者龈沟液和血清IL-6、IL-8和PAF水平的影响[J]. 实用临床医药杂志, 2015, 19(19): 67-69, 85.Zhao L, Cao Y.Influence of periodontal basic treat-ment on levels of GCF and serum IL-6, IL-8 and PAF in patients with periodontitis[J]. J Clin Med Pract, 2015, 19(19): 67-69, 85.
[22] 郦兴, 寿建刚, 何谨, 等. 种植体周围炎患者龈沟液中IL-8、IL-18的水平检测及意义[J]. 医学研究杂志, 2015, 44(10): 155-158.Li X, Shou JG, He J, et al.IL-8, IL-18 expression in peri-implant gingival crevicular fluid and clinical significance[J]. J Med Res, 2015, 44(10): 155-158.
[23] 祝媛, 余美芳, 肖云鹤, 等. 牙周炎患者种植义齿修复后口腔自我维护的临床观察[J]. 临床口腔医学杂志, 2015, 31(7): 418-420.Zhu Y, Yu MF, Xiao YH, et al.The clinical observa-tion of oral self-protection in patients with periodon-titis after implant restoration[J]. J Clin Stomatol, 2015, 31(7): 418-420.
[1] Tang Chunbo. Restorative space in edentulous patients and the clinical decision of implant restoration [J]. Int J Stomatol, 2024, 51(1): 1-9.
[2] Lu Qian,Xia Haibin,Wang Min.. Research progress on implantoplasty in the treatment of peri-implantitis [J]. Int J Stomatol, 2023, 50(2): 152-158.
[3] Man Yi, Huang Dingming. Combined treatment strategy of oral implantology and endodontic microsurgery for bone augmentation and en-dodontic diseases in aesthetic area (part 1): application basis and indications [J]. Int J Stomatol, 2022, 49(5): 497-505.
[4] Cao Zhengguo. Periodontal considerations in prosthetic dentistry [J]. Int J Stomatol, 2022, 49(1): 1-11.
[5] Qi Xiaoling,Gan Tingbin,Huang Jiao. Research progress on the relationship between chronic periodontitis and chronic kidney disease [J]. Int J Stomatol, 2021, 48(1): 18-22.
[6] Zheng Guiting,Xu Yan,Wu Mingyue. Research progress and consensus of experts on the therapy of peri-implant diseases [J]. Int J Stomatol, 2020, 47(6): 725-731.
[7] Tong Zian,Si Misi. Advances in the decontamination of plaque on implant surface in vitro [J]. Int J Stomatol, 2020, 47(5): 589-594.
[8] Zhang Min,Wan Haoyuan. Research progress on drug and laser therapy for peri-implantitis [J]. Int J Stomatol, 2020, 47(4): 463-470.
[9] Wu Qiuyue,Li Zhibang. Research progress on the adjunctive drug therapy of peri-implantitis [J]. Int J Stomatol, 2020, 47(4): 471-477.
[10] Qing Wei,Huang Lijuan,Zheng Jiajun,Ren Jing,Li Chenglong,Tuo Qiang,Ren Xiaohua,Mu Yandong. Shift of microbial composition of peri-implant gingival crevicular fluid as revealed by 16S ribosomal DNA high-throughput sequencing [J]. Int J Stomatol, 2019, 46(5): 532-539.
[11] Yuan Zhenying,Guan Cuiqiang,Nan Xinrong. Research progress on DNA methylation and oral disease [J]. Int J Stomatol, 2019, 46(4): 437-441.
[12] Xu Feng,Yi Zhang,Menghong Li,Nan Liu,Liuyi Wang,Min. Hu. Research progress on the influence of removable clear aligners on periodontal health [J]. Inter J Stomatol, 2019, 46(2): 166-170.
[13] Li Lin, Wang Dan, Zhao Manzhu, Tang Ming. Research progress on the correlation between chronic periodontitis and neurodegenerative diseases [J]. Inter J Stomatol, 2017, 44(5): 514-518.
[14] Yang Chunyan, Shui Yanqing. Research progress on association between single nucleotide polymorphism and chronic periodontitis [J]. Inter J Stomatol, 2017, 44(4): 452-458.
[15] Zhao Hong, Wang Xinlin, Lü Zhi, Wang Dongqing, Su Jianrong. Microbiological community analysis by high-throughput sequencing of subgingival plaque in patients with chronic periodontitis before and after subgingival scaling and root planing [J]. Inter J Stomatol, 2017, 44(3): 294-300.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[9] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[10] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .