Int J Stomatol

Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (1): 72-75.doi: 10.7518/gjkq.2013.01.019

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Overexpression of the αvβ6 integrin in oralsquamous cell carcinoma is a specific targettor for treatment

Sang Lei 1，2 , Li Hongwei 2，3.   

  1. 1. Dept. of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Suzhou Health College, Suzhou 215002, China; 2. Research Institute of Stomatology, Nanjing Medical University, Nanjing 210029, China; 3. Dept. of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing 210029, China
  • Received:2012-04-16 Revised:2012-10-19 Online:2013-01-01 Published:2013-01-01

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Abstract:

Integrin-αvβ6 is a special integrin subtype, which highly express in cancer and healing wound, but did not express in normal tissue and benign tumor. By promoting tumor cell migration and extracellular matrix degradation, activating cytokine transforming growth factor-β1 and inhibiting tumor cell programmed cell death lead to tumor invasion and metastasis. Further study of integrin-αvβ6 expression and function in oral cancer will help to understand the molecular mechanisms of invasion and metastasis, provide oral squamous cell carcinoma treatment with new ideas and methods.

Key words: integrin, oral squamous cell carcinoma, invasion and metastasis, epithelial—mesenchymaltransformation, programmed cell death


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