Int J Stomatol

Inter J Stomatol ›› 2012, Vol. 39 ›› Issue (2): 260-264.doi: 10.3969/j.issn.1673-5749.2012.02.035

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Pathomechanism of phenytoin-induced gingival over-growth

Xiao Juan, Zhao Hui, Liu Fuxiang.   

  1. Dept. of Implantation, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2011-02-28 Revised:2011-12-08 Online:2012-03-01 Published:2012-03-01

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Abstract:

Phenytoin sodium is widely used to cure antiepileptic, trigeminal neuralgia, sciatica, paroxysmal choreoathetosis, myotonia, arrhythmia, hypertension and so, but a common and well-known adverse effect of its administration is gingival over -growth which may influence the aesthetics and oral function. The pathogenesis of Phenytoin sodium-induced gingival over-growth is not very clear now. This review summarized the mechanism of Phenytoin sodium-induced gingival over-growth, fibroblast cell proliferation and programmed cell death, collagen homeostasis, extracellular matrix accumulation and inflammation mechanism.

Key words: Phenytoin sodium, collagen, gingival over-growth, inflammation


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