Int J Stomatol

Inter J Stomatol ›› 2011, Vol. 38 ›› Issue (5): 592-595.doi: 10.3969/j.issn.1673-5749.2011.05.026

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Role of oxidative stress in the pathogenesis of diabetes-related periodontitis

Xu Huixia, Fu Yun.   

  1. Dept. of Periodontics, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat -Sen University, Guangzhou 510055, China
  • Received:2010-12-31 Revised:2011-06-20 Online:2011-09-20 Published:2011-09-20

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Abstract:

In the research of pathogenesis of diabetes-related periodontitis, oxidative stress could be activated by long-term chronic hyperglycemia of diabetics via multiple processes, which contributes to accumulation of reactive oxygen species（ROS） in periodontal tissues. While ROS alters signal transduction path, leading to abnormality of inflammatory factor’s gene and protein expression, which amplify host inflammatory response, ultimately perioodontitis occur. The purpose of this review is to provide an overview of the research of concerning pathogenesis of diabetes-related periodontitis, in regard of different path of oxidative stress activation, mechanism of oxidative stress and therapeutic prospect of antioxidums in treatment of diabetes-related periodontitis.

Key words: oxidative stress, reactive oxygen species, diabetes, periodontitis


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