Int J Stomatol

Int J Stomatol ›› 2021, Vol. 48 ›› Issue (4): 380-384.doi: 10.7518/gjkq.2021081

• Periodontitis • Previous Articles     Next Articles

Research progress on the relationship between hypothyroidism and periodontitis

Zhu Xuanzhi(),Zhao Lei()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-01-05 Revised:2021-03-27 Online:2021-07-01 Published:2021-06-30
  • Contact: Lei Zhao E-mail:826868536@qq.com;jollyzldoc@163.com
  • Supported by:
    National Natural Science Foundation of China(81970944)

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Abstract:

The thyroid gland regulates various physiological activities by secreting thyroid hormones, and its abnormal function can lead to bone metabolism disorders and osteoporosis. Periodontitis is a chronic inflammatory disease caused by plaque biofilm, and alveolar bone resorption is one of its primary features. Clinical trials and animal experiments indicated that hypothyroidism is positively related to periodontal disease. Hypothyroidism may affect bone metabolism and the expression of immune factors by regulating the activation of downstream hormone receptors, thereby inhibiting alveolar bone osteogenesis and promoting bone resorption. In addition, low-turnover osteoporosis caused by hypothyroidism may be a systemic condition that aggravates the progression of periodontitis. This article reviews the relevance and possible mechanisms of the above two diseases.

Key words: hypothyroidism, bone metabolism, periodontitis, dental implant

CLC Number: 

  • R781.4

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[1] Cardoso EM, Reis C, Manzanares-Céspedes MC. Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases[J]. Postgrad Med, 2018,130(1):98-104.
doi: 10.1080/00325481.2018.1396876 pmid: 29065749
[2] Slots J. Periodontitis: facts, fallacies and the future[J]. Periodontol 2000, 2017,75(1):7-23.
doi: 10.1111/prd.12221
[3] Mendoza A, Hollenberg AN. New insights into thyroid hormone action[J]. Pharmacol Ther, 2017,173:135-145.
doi: 10.1016/j.pharmthera.2017.02.012
[4] Chaker L, Bianco AC, Jonklaas J, et al. Hypothyroidism[J]. Lancet, 2017,390(10101):1550-1562.
doi: S0140-6736(17)30703-1 pmid: 28336049
[5] Williams GR, Bassett JHD. Thyroid diseases and bone health[J]. J Endocrinol Invest, 2018,41(1):99-109.
doi: 10.1007/s40618-017-0753-4
[6] Schneider LC. Periodontal disease in hypothyroid adult rats[J]. Arch Oral Biol, 1969,14(10):1169-1175.
pmid: 4187861
[7] Rahangdale SI, Galgali SR. Periodontal status of hypothyroid patients on thyroxine replacement therapy: a comparative cross-sectional study[J]. J Indian Soc Periodontol, 2018,22(6):535-540.
doi: 10.4103/jisp.jisp_316_18 pmid: 30631233
[8] Yerke L, Levine M, Cohen R. MON-616 potential relationship between hypothyroidism and periodontal disease severity[J]. J Endocr Soc, 2019, 3(Suppl 1): MON-616.
[9] Beriashvili S, Nikolaishvili M, Mantskava M, et al. Changes in tooth hard tissue minerali-zation and b-lood rheology in healthy adolescents and those with thyroid dysfunction[J]. Georgian Med News, 2016(Issue):28-34.
pmid: 28009312
[10] Bhankhar RR, Hungund S, Kambalyal P, et al. Effect of nonsurgical periodontal therapy on thyroid stimulating hormone in hypothyroid patients with periodontal diseases[J]. Indian J Dent Res, 2017,28(1):16-21.
doi: 10.4103/ijdr.IJDR_174_16 pmid: 28393812
[11] Leite SAM, Casanovas RC, Rodrigues VP, et al. The effect of nonsurgical periodontal therapy on hepcidin and on inflammatory and iron marker levels[J]. Braz Oral Res, 2019,33:e055.
doi: 10.1590/1807-3107bor-2019.vol33.0055
[12] Aldulaijan HA, Cohen RE, Stellrecht EM, et al. Relationship between hypothyroidism and periodontitis: a scoping review[J]. Clin Exp Dent Res, 2020,6(1):147-157.
doi: 10.1002/cre2.247 pmid: 32067402
[13] Feitosa DS, Marques MR, Casati MZ, et al. The influence of thyroid hormones on periodontitis-related bone loss and tooth-supporting alveolar bone: a histological study in rats[J]. J Periodontal Res, 2009,44(4):472-478.
doi: 10.1111/jre.2009.44.issue-4
[14] Shcherba V, Havrylenko Y, Krynytska I, et al. A comparative study of oral microbiocenosis structure in experimental comorbidity-free periodontitis and in periodontitis combined with thyroid dysfunction[J]. Pol Merkur Lekarski, 2020,48(283):32-38.
[15] Shcherba V, Machogan V, Luchynskyi V, et al. Correlation between connective tissue metabolism and thyroid dysfunction in rats with periodontitis[J]. Geo-rgian Med News, 2019(297):145-149.
[16] Dixon DR, London RM. Restorative design and associated risks for peri-implant diseases[J]. Periodontol 2000, 2019,81(1):167-178.
doi: 10.1111/prd.v81.1
[17] Attard NJ, Zarb GA. A study of dental implants in medically treated hypothyroid patients[J]. Clin Implant Dent Relat Res, 2002,4(4):220-231.
doi: 10.1111/cid.2002.4.issue-4
[18] Dalago HR, Schuldt Filho G, Rodrigues MA, et al. Risk indicators for Peri-implantitis. A cross-sectio-nal study with 916 implants[J]. Clin Oral Implants Res, 2017,28(2):144-150.
[19] Feitosa Dda S, Bezerra Bde B, Ambrosano GM, et al. Thyroid hormones may influence cortical bone healing around titanium implants: a histometric stu-dy in rats[J]. J Periodontol, 2008,79(5):881-887.
doi: 10.1902/jop.2008.070466
[20] Bassett JH, Williams GR. Role of thyroid hormones in skeletal development and bone maintenance[J]. Endocr Rev, 2016,37(2):135-187.
doi: 10.1210/er.2015-1106
[21] Saraiva PP, Teixeira SS, Padovani CR, et al. Triiodothyronine (T3) does not induce Rankl expression in rat Ros 17/2.8 cells[J]. Arq Bras Endocrinol Meta-bol, 2008,52(1):109-113.
[22] Baliram R, Latif R, Zaidi M, et al. Expanding the role of thyroid-stimulating hormone in skeletal phy-siology[J]. Front Endocrinol (Lausanne), 2017,8:252.
doi: 10.3389/fendo.2017.00252
[23] Apostu D, Lucaciu O, Oltean-Dan D, et al. The influence of thyroid pathology on osteoporosis and fracture risk: a review[J]. Diagnostics (Basel), 2020,10(3):E149.
[24] Lademann F, Tsourdi E, Hofbauer LC, et al. Thyroid hormone actions and bone remodeling‒the role of the Wnt signaling pathway[J]. Exp Clin Endocrinol Diabetes, 2020,128(6/7):450-454.
doi: 10.1055/a-1088-1215
[25] Keller J, Catala-Lehnen P, Huebner AK, et al. Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts[J]. Nat Commun, 2014,5:5215.
doi: 10.1038/ncomms6215
[26] Shemanko C, Cong YY, Forsyth A. What is breast in the bone[J]. Int J Mol Sci, 2016,17(10):1764.
doi: 10.3390/ijms17101764
[27] Wang CJ, McCauley LK. Osteoporosis and perio-dontitis[J]. Curr Osteoporos Rep, 2016,14(6): 284-291.
[28] Delitala AP, Scuteri A, Doria C. Thyroid hormone diseases and osteoporosis[J]. J Clin Med, 2020,9(4):1034.
doi: 10.3390/jcm9041034
[29] Allain TJ, Thomas MR, McGregor AM, et al. A histomorphometric study of bone changes in thyroid dysfunction in rats[J]. Bone, 1995,16(5):505-509.
pmid: 7654465
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