Int J Stomatol ›› 2019, Vol. 46 ›› Issue (6): 705-710.doi: 10.7518/gjkq.2019104

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Research progress on the mechanism of Candida albicans in oral carcinogenesis

Wen Shuqiong,Guo Junyi,Dai Wenxiao,Wang Dikan,Wang Zhi()   

  1. Guanghua School of Stomatology, Dept. of Oral Medicine, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2019-02-24 Revised:2019-05-16 Online:2019-11-01 Published:2019-11-14
  • Contact: Zhi Wang
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81772896)


Microbial infection is one of the important causes of carcinogenesis. To date, an increasing number of researches have indicated that Candida albicans can increase the patients’ risk of carcinogenesis and tumor metastasis through the immunosuppressive state. Recent studies have demonstrated that Candida albicans promote the carcinogenesis through several mechanisms such as producing carcinogenic byproducts, triggering inflammation and inducing T helper cell 17 response. Here, we provide an overview of the research progress of oncogenic potential of Candida albicans and discuss the relationship between Candida albicans and cancer, trying to provide new ideas for the prevention and treatment of oral cancer.

Key words: Candida albicans, carcinogen, carcinogenesis, inflammation, T helper cell 17 immune response

CLC Number: 

  • R781.5 +4


Fig 1

Candida albicans invades oral epithelial cells"

Fig 2

Candida albicans promotes oral cancer through chronic inflammation"

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