国际口腔医学杂志

国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (1): 55-58.doi: 10.7518/gjkq.2018.01.011

• 综述 • 上一篇    下一篇

牙龈干细胞生物学潜能的研究进展

刘珍珍, 方蛟, 赵静辉, 邹净亭, 相星辰, 王佳, 周延民   

  1. 吉林大学口腔医院种植科,吉林省牙发育及颌骨重塑与再生重点实验室 长春 130021
  • 收稿日期:2017-05-28 修回日期:2017-09-14 发布日期:2018-01-15
  • 通讯作者: 周延民,教授,博士,Email：zhouym@jlu.edu.cn
  • 作者简介:刘珍珍,住院医师,硕士,Email：lzz423@163.com
  • 基金资助:
    高等学校博士学科点专项科研基金（20120061110077）; 国家自然科学基金（81200809）; 吉林省教育厅“十二五”科学技术研究项目（吉教科合字[2015]第532号）; 吉林大学研究生创新基金资助项目（2017014,2017063）

A review on recent developments in pluripotency of gingiva-derived mesenchymal stem cells

Liu Zhenzhen, Fang Jiao, Zhao Jinghui, Zou Jingting, Xiang Xingchen, Wang Jia, Zhou Yanmin   

  1. Dept. of Implantology, Hospital of Stomatology, Jilin University Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China; Dept. of Implantology, Hospital of Stomatology, Jilin UniversityJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China
  • Received:2017-05-28 Revised:2017-09-14 Published:2018-01-15
  • Supported by:
    This study was supported by Specialized Research Fund for the Doctoral Program of Higher Education of China (20120061110077), National Natural Science Foundation of China (81200809), Science and Technology Research Project of Jilin Provincial Education Department in 12th Five-Year ([2015]532) and Project Supported by Graduate Innovation Fund of Jilin University (2017014, 2017063).

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摘要： 间充质干细胞（MSC）可从多种人体组织中分离获得,具有自我更新和多向分化的潜能。目前已证实,牙龈组织中也存在MSC,即牙龈干细胞（GMSC）。GMSC易于分离获得,表型稳定,增殖速度快,体外长期培养时还能维持正常的核型和端粒酶活性,日益成为组织工程和再生医学研究的干细胞来源。本文就其分离鉴定、生物学特性、分化能力等方面的研究进展作一综述。

关键词: 间充质干细胞, 牙龈干细胞, 分化, 组织再生

Abstract: Mesenchymal stem cells (MSCs) which can be isolated from multiple tissue, have two specific characteristics: self-renewal and multi- or pluripotency. Recent evidence has shown that MSCs also located in gingiva, then be named as gingiva-derived mesenchymal stem cells (GMSCs). GMSCs represent a unique population of MSCs that can be easily isolated and obtained. In addition to maintaining a normal karyotype and telomerase activity in long-term cultures, GMSCs can display a stable phenotype and rapidly proliferate in vitro. Therefore, GMSCs are increasingly become the sources of stem cells for tissue engineering and regenerative medicine research. This review described the research progress of GMSCs’ separation and identification, biological characteristics and differentiation ability and so on.

Key words: mesenchymal stem cells, gingiva-derived mesenchymal stem cells, differentiation, tissue regeneration

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