国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (6): 690-695.doi: 10.7518/gjkq.2021106

• 综述 • 上一篇    下一篇



  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙周病科 成都 610041
  • 收稿日期:2021-02-24 修回日期:2021-07-16 出版日期:2021-11-01 发布日期:2021-10-28
  • 通讯作者: 王骏
  • 作者简介:施培磊,博士,Email: shipeilei0222@outlook.com
  • 基金资助:

Research progress on the application of dental-derived mesenchymal stem cells in periodontal defect repair

Shi Peilei(),Yu Chenhao,Xie Xudong,Wu Yafei,Wang Jun()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-02-24 Revised:2021-07-16 Online:2021-11-01 Published:2021-10-28
  • Contact: Jun Wang
  • Supported by:
    National Natural Science Foundation of China(82071127);National Natural Science Foundation of China(81700980);Sichuan Province Science and Technology Support Program(2019YJ0097)



关键词: 牙源性间充质干细胞, 牙周组织修复, 组织工程, 牙周炎


Periodontitis is a chronic infectious disease characterized by the destruction of periodontal tissue and is the most common cause of tooth loss among adults. The periodontium is a complex structure composed of soft and hard tissues; hence, the regeneration of its tissues is a challenging task. Self-renewal, multipotency, and accessibility make dental-derived mesenchymal stem cells an attractive source for periodontal tissue regeneration. With the development of cell-sheet engineering, biomaterial scaffolds, and 3D printing, dental-derived mesenchymal stem cells show great potential as seed cells in repairing periodontal tissue defects. This paper reviews the research progress on the application of dental-derived mesenchymal stem cells in periodontal defect repair.

Key words: dental-derived mesenchymal stem cell, periodontal tissue repair, tissue engineering, periodontitis


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