Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (1): 51-54.doi: 10.7518/gjkq.2013.01.014

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Research progress on microRNA-181a and its function in malignant tumors

He Qianting, Wang Anxun.   

  1. Dept. of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
  • Received:2012-01-14 Revised:2012-08-13 Online:2013-01-01 Published:2013-01-01

Abstract:

MicroRNA is a kind of small noncoding RNA that regulates the expression of different genes and plays an important role in cancer cell invasion, migration and metastasis. Recently, research shows that micro- RNA-181a(miR-181a) regulates processes of cell differentiation, the immune system, tumorigenesis, tumor development and prognosis. This review introduced the structure of miR-181a and its function in the tumorigenesis and development, especially the research progress on the oral and maxillofacial malignancy, providing the theoretical basis for further study on miR-181a.

Key words: microRNA-181a, oral squamous cell carcinoma, tumor suppressor


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