Abstract: Collagen possesses weak antigenic activity, high biocompatibility, biodegradability, and biomechanical properties. It has been widely used in tissue engineering of various organs, such as skin, tendons, blood vessels, nerves, and bones. Growth factors are a class of molecules that effectively regulate cell metabolism and tissue repair. Collagengrowth factor biomaterials(CGFB) exhibit desirable biological and biomechanical properties in osteogenesis, nerve repair, tendon reconstruction, and repair of chronic wounds. In the process of osteogenesis, CGFB ideally release growth factors, effectively inducing osteogenic differentiation of stem cells, thus promoting repair in bone defects. In the process of nerve repair, a specific design of CGFB for a purpose can effectively promote neuritis generation. In the process of central nervous system repair, the injection of collagen gel can provide a desirable microenvironment for cells, which is beneficial for central nervous system repair. This article reviews the basic properties and recent studies in bone and nerve repair of CGFB to provide future direction of improvement.

Key words: collagen, growth factor, tissue engineering, bone regeneration, nerve regeneration