Int J Stomatol

Inter J Stomatol ›› 2016, Vol. 43 ›› Issue (6): 734-738.doi: 10.7518/gjkq.2016.06.025

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Role of microRNA-205 on chemoresistance and its mechanism in tumor

Li Long, Huang Hongzhang.   

  1. Dept. of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Online:2016-11-01 Published:2016-11-01

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Abstract: Resistance to chemotherapeutic drugs is a difficult problem that often leads to the failure of chemotherapy in tumor clinical treatment. Chemoresistance mechanism involves the complex and unclear regulation of multiple genes and signaling pathways. MicroRNA(miRNA) are endogenous, small non-coding, single-strand RNA molecules that are 18-25 nucleotides in length. They play a crucial role in regulating various cellular biological processes. Accumulated studies show that aberrant expression of miRNA is associated with progression, migration, and chemotherapy resistance in various cancers. Recently, an increasing number of studies reveal that miRNA-250(miR-205) participates in regulating chemotherapy resistance in cancers. However, the role of miR-205 in chemoresistance is still unclear. This paper reviews the relationship between miR-205 and chemotherapy resistance in tumors.

Key words: microRNA-205, tumor, chemoresistance


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