Int J Stomatol ›› 2024, Vol. 51 ›› Issue (4): 401-405.doi: 10.7518/gjkq.2024052

• Periodontitis • Previous Articles     Next Articles

The effect of supportive periodontal therapy on blood cell indicators in patients with periodontitis: a retrospective study

Mengjie Chen1(),Xiaole Liu2,Lilei Zhu2()   

  1. 1.Graduate School, Hunan University of Chinese Medicine, Changsha 410208, China
    2.Dept. of Periodontology, Changsha Stomatological Hospital, Changsha 410000, China
  • Received:2023-03-15 Revised:2024-01-15 Online:2024-07-01 Published:2024-06-24
  • Contact: Lilei Zhu E-mail:1174052274@qq.com;79447337@qq.com
  • Supported by:
    Scientific Research Project of Health Commission of Hunan Province(D202308017691)

Abstract:

Objective This study aimed to investigate the effect of supportive periodontal therapy (SPT) on blood cell indicators in patients with periodontitis. Methods In accordance with the inclusion and exclusion criteria, patients who were diagnosed with periodontitis at Changsha Stomatological Hospital from January 2014 to March 2022 were included. On the basis of whether SPT was performed on patients or not, patients were divided into maintenance group (74 patients) and nonmaintenance group (76 patients) to compare the differences in blood cell indicators between the two groups. Results After treatment, the neutrophil count (N), white blood cell count (WBC), platelet count (PLT), and systemic immune-inflammation index (SII) of the maintenance group decreased (P<0.05); the mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), and mean platelet volume (MPV) increased (P<0.05); the hemoglobin (HGB) showed no significant change (P>0.05). The SII of the nonmaintenance group decreased, whereas the MPV and MCV increased (P<0.05). By comparing the changes in blood cell indicators, we found significant differences in WBC, N, PLT, SII, MCV, MCHC, and MPV between the two groups (P<0.05). During the 5-year follow-up period, a decreasing trend in WBC, N, PLT, and SII and an increasing trend in MCHC, MPV, and MCV in the maintenance group were observed. Conclusion Active SPT could improve the hematological parameters of patients, alleviate the immune and inflammatory imbalance, and benefit the maintenance and improvement of the treatment effect.

Key words: periodontitis, supportive periodontal therapy, blood cell

CLC Number: 

  • R781.4

TrendMD: 

Tab 1

Comparison of the conditions of patients in the two groups at the initial consultation"

项目定期支持治疗组不定期支持治疗组P
样本数7476
性别(男/女)38/3639/370.997

年龄(岁,xˉ±s

PD(mm,xˉ±s

AL(mm,xˉ±s

BI(xˉ±s

43.22±10.04

3.45±0.38

3.57±0.35

2.12±0.77

42.70±10.00

3.49±0.31

3.63±0.30

2.13±0.69

0.717

0.492

0.330

0.545

Tab 2

Comparison of periodontal clinical indicators between the two groups of patients"

牙周临床指标定期支持治疗组不定期支持治疗组
治疗前末次治疗后治疗前末次治疗后
PD(mm)3.45±0.382.52±0.44*#3.49±0.313.41±0.31
AL(mm)3.57±0.352.73±0.45*#3.63±0.303.57±0.28
BI2.12±0.771.38±0.53*#2.13±0.692.06±0.56

Tab 3

Comparison of blood cell indicators between the two groups of patients"

血细胞指标定期支持治疗组不定期支持治疗组
治疗前末次治疗后治疗前末次治疗后
N(109/L)3.92±1.323.18±1.11*#3.79±1.013.60±1.23
WBC(109/L)6.35±1.635.60±1.52*#6.17±1.486.11±1.54
MCV(fL)93.10±4.5296.75±6.90*#93.25±5.5994.12±5.69*
HGB(g/L)142.16±12.36142.35±15.00140.72±15.52140.84±14.07
MCHC(g/L)317.97±7.66322.77±10.27*#318.34±7.00318.11±7.36
PLT(109/L)232.86±56.77219.55±53.71*#242.38±44.64239.24±45.25
MPV(fL)8.42±0.869.03±0.90*#8.33±0.888.69±0.76*
SII(109/L)503.93±258.01379.76±187.06*#517.69±197.23456.45±200.46*

Fig 1

Variation trends of blood cells"

1 Kwon T, Lamster IB, Levin L. Current concepts in the management of periodontitis[J]. Int Dent J, 2021, 71(6): 462-476.
2 Genco RJ, Sanz M. Clinical and public health impli-c-ations of periodontal and systemic diseases: an overview[J]. Periodontol 2000, 2020, 83(1): 7-13.
3 Highfield J. Diagnosis and classification of perio-dontal disease[J]. Aust Dent J, 2009, 54(): S11-S26.
4 Yang YL, Wu CH, Hsu PF, et al. Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease[J]. Eur J Clin Invest, 2020, 50(5): e13230.
5 束蓉, 倪靖. 2018牙周病和植体周病国际新分类——牙周炎分期分级疾病定义系统临床应用体会[J].口腔医学, 2020, 40(1): 1-6.
Shu R, Ni J. 2018 international classification of pe-riodontal diseases and implant diseases: clinical application of staging and grading of periodontitis[J]. Stomatology, 2020, 40(1): 1-6.
6 Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation[J]. Nat Rev Immunol, 2015, 15(1): 30-44.
7 Martínez-García M, Hernández-Lemus E. Periodontal inflammation and systemic diseases: an overview[J]. Front Physiol, 2021, 12: 709438.
8 Bhattacharya HS, Srivastava R, Gummaluri SS, et al. Comparison of blood parameters between perio-dontitis patients and healthy participants: a cross-sectional hematological study[J]. J Oral Maxillofac Pathol, 2022, 26(1): 77-81.
9 Chen LL, Deng HD, Cui HM, et al. Inflammatory responses and inflammation-associated diseases in organs[J]. Oncotarget, 2018, 9(6): 7204-7218.
10 Singh P, Tushar, Sharma S, et al. Evaluation of inflammatory acute phase protein level and different leukocyte counts in chronic periodontitis normolipi-demic patients after nonsurgical periodontal therapy[J]. J Contemp Dent Pract, 2021, 22(4): 373-377.
11 Botelho J, Machado V, Hussain SB, et al. Periodontitis and circulating blood cell profiles: a systematic review and meta-analysis[J]. Exp Hematol, 2021, 93: 1-13.
12 Ganz T. Anemia of inflammation[J]. N Engl J Med, 2019, 381(12): 1148-1157.
13 Han Y, Luo ZQ, Yue ZG, et al. The tendency of anemia of inflammation in periodontal diseases[J]. Clin Sci (Lond), 2023, 137(3): 251-264.
14 Herster F, Karbach S, Chatterjee M, et al. Platelets: underestimated regulators of autoinflammation in psoriasis[J]. J Invest Dermatol, 2021, 141(6): 1395-1403.
15 Mutthineni RB, Ramishetty A, Gojja P, et al. Platelet indices be a new biomarker for periodontal di-sease[J]. Contemp Clin Dent, 2021, 12(3): 289-293.
16 Zhan YL, Lu RF, Meng HX, et al. Platelets as inflammatory mediators in a murine model of perio-dontitis[J]. J Clin Periodontol, 2020, 47(5): 572-582.
17 Liu YH, Ye T, Chen L, et al. Systemic immune-inflammation index predicts the severity of coronary stenosis in patients with coronary heart disease[J]. Coron Artery Dis, 2021, 32(8): 715-720.
18 Öcal L, Keskin M, Cerşit S, et al. Systemic immune-inflammation index predicts in-hospital and long-term outcomes in patients with ST-segment elevation myocardial infarction[J]. Coron Artery Dis, 2022, 33(4): 251-260.
19 Wang J, Zhou DP, Dai ZJ, et al. Association between systemic immune-inflammation index and diabetic depression[J]. Clin Interv Aging, 2021, 16: 97-105.
20 Mishra S, Johnson L, Gazala MP, et al. Systemic immune-inflammation index in patients with genera-lized stage Ⅲ grade C periodontitis[J]. Oral Dis, 2023, 29(8): 3599-3609.
21 Luo HC, He LB, Zhang GJ, et al. Normal reference intervals of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and systemic immune inflammation index in healthy adults: a large multi-center study from Western China[J]. Clin Lab, 2019, 65(3): 255-265.
[1] Meiyao Qi,Xingying Qi,Xinyi Zhou,Zhen Tan,Quan Yuan. Therapeutic effect of cannabidiol combined with minocycline on periodontitis [J]. Int J Stomatol, 2024, 51(4): 392-400.
[2] Yu Ma,Yu Zuo,Jianhua Liu. Meta-analysis of the efficacy of antimicrobial photodynamic therapy and systemic antimicrobial drug as an adjunct treatment for periodontitis [J]. Int J Stomatol, 2024, 51(4): 406-415.
[3] Shili Liu, Lei Zhao. Progress of research on the correlation between periodontitis and heart failure [J]. Int J Stomatol, 2024, 51(4): 425-432.
[4] Zaimu Yang,Pei Cao,Zhenhua Liu,Qingxian Luan. Correlation study of plasma cell-free extra-mitochondrial mitochondria DNA and periodontitis clinical parameters [J]. Int J Stomatol, 2024, 51(3): 288-295.
[5] Yuhong Ma,Lei Zhao. Process and progress in the clinical research of minimally invasive non-operative periodontal therapy technology [J]. Int J Stomatol, 2024, 51(2): 227-232.
[6] Fu Yu, He Wei, Huang Lan. Ferroptosis and its implication in oral diseases [J]. Int J Stomatol, 2024, 51(1): 36-44.
[7] Luo Xiaojie,Wang Dexu,Chen Xiaotao. Relationship between periodontitis and ferroptosis based on bioinformatics analysis [J]. Int J Stomatol, 2023, 50(6): 661-668.
[8] Huang Yuanhong,Peng Xian,Zhou Xuedong.. Progress in research into the effect of Rhizoma Drynariae on the treatment of bone-related diseases in the oral cavity [J]. Int J Stomatol, 2023, 50(6): 679-685.
[9] Hu Jia,Wang Xiuqing,Lu Guoying,Huang Xiaojing.. Regenerative endodontic procedures for permanent tooth with immature apices in adult patients [J]. Int J Stomatol, 2023, 50(6): 686-695.
[10] Gong Meiling,Cheng Xingqun,Wu Hongkun.. Research progress on the correlation between Parkinson’s disease and periodontitis [J]. Int J Stomatol, 2023, 50(5): 587-593.
[11] Xu Zhibo,Meng Xiuping.. Research progress on mechanism of Enterococcus faecalis escaping host immune defense [J]. Int J Stomatol, 2023, 50(5): 613-617.
[12] Sun Jia,Han Ye,Hou Jianxia. Research progress on the role of interleukin-6-hepcidin signal axis in regulating the pathogenesis of periodontitis-associated anemia [J]. Int J Stomatol, 2023, 50(3): 329-334.
[13] Liang Zhiying,Zhao Yuanxi,Zhu Jiani,Su Qin.. Retrospective analysis of clinical data of 288 cases of endodontic microsurgery on anterior teeth [J]. Int J Stomatol, 2023, 50(2): 166-171.
[14] Liu Tiqian,Liang Xing,Liu Weiqing,Li Xiaohong,Zhu Rui.. Research progress on the role and mechanism of occlusal trauma in the development of periodontitis [J]. Int J Stomatol, 2023, 50(1): 19-24.
[15] Li Qiong,Yu Weixian. Research progress on resveratrol for the treatment of periodontitis and its bioavailability [J]. Int J Stomatol, 2023, 50(1): 25-31.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Zhang Xuewen,Li Cong,Xu Xiaoyin,Gao Jing,Shen Jing. Hybrid light source in vital dental bleaching[J]. Int J Stomatol, 2021, 48(6): 683 -689 .