Int J Stomatol

Int J Stomatol ›› 2025, Vol. 52 ›› Issue (1): 117-122.doi: 10.7518/gjkq.2025014

• Reviews • Previous Articles    

Research progress on the correlation between serum amyloid A and periodontitis

Shouzheng Cheng(),Taiwen Li,Lei Zhao()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Periodontology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2024-05-07 Revised:2024-08-19 Online:2025-01-01 Published:2025-01-11
  • Contact: Lei Zhao E-mail:15138970198@163.com;jollyzldoc@163.com
  • Supported by:
    National Natural Science Foundation of China(81970944)

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Abstract:

Periodontitis is a chronic inflammatory disease characterized by periodontal tissue inflammation and alveolar bone resorption. Serum amyloid A (SAA) is a kind of acute phase reactive protein. The level of SAA increases rapidly after the body is stimulated by infection, trauma, inflammation, and so on. Recent research has analyzed the gene regulation, protein structure, and biological functions of SAA, revealing that SAA promotes osteoclast differentiation and bone resorption by modulating the release of inflammatory mediators and the function of immune cells. These findings suggest that SAA is closely linked to the occurrence and progression of periodontitis. Therefore, reviews on the classification, structure, function, and roles of SAA in the pathogenesis of periodontitis are crucial to provide new clues to the pathogene-sis, prevention, and treatment of periodontitis.

Key words: periodontitis, serum amyloid protein A, T helper cell 17, Toll-like receptor 2

CLC Number: 

  • R781.4

TrendMD: 
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