Int J Stomatol

Int J Stomatol ›› 2024, Vol. 51 ›› Issue (6): 706-712.doi: 10.7518/gjkq.2024099

• Original Articles • Previous Articles    

Correlation analysis between the systemic immune-inflammatory index and graded diagnosis in patients with perio-dontitis

Mengjie Chen1,2(),Wenhua Xu1,2,Qingqing Liu1,2,Yudan Kang1,Rong Liu1,Lilei Zhu1,2()   

  1. 1.School & Hospital of Stomatology, Hunan University of Chinese Medicine, Changsha 410208, China
    2.Dept. of Perio-dontal Mucosa, Changsha Stomatological Hospital, Changsha 410004, China
  • Received:2024-02-25 Revised:2024-06-30 Online:2024-11-01 Published:2024-11-04
  • Contact: Lilei Zhu E-mail:1174052274@qq.com;csskqyy_zhulilei@qq.com
  • Supported by:
    Scientific Research Plan Project of Health Commission of Hunan Province(202208013498);Undergraduate Innovation Scientific Research Project of Hunan University of Chinese Medicine(2023BKS141)

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Abstract:

Objective This study aimed to investigate the correlation between the systemic immune-inflammatory index (SII) and the diagnosis of periodontitis grading. Methods According to the inclusion and exclusion criteria, patients who attended Changsha Stomatological Hospital from January to October 2023 were screened and divided into the perio-dontitis group (131 patients) and the periodontal health group (132 patients). The differences in SII, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR) were analyzed between the two groups. We used Logistic regression analysis and receiver operating characteristic curve to analyze the factors related to the prevalence and diagnostic value of periodontitis. Spearman correlation analysis was conducted to determine the correlation between blood cell indicators and pe-riodontitis grading. Results SII, NLR, and PLR were significantly higher and LMR was significantly lower in the periodontitis group compared with the periodontal health group (P<0.05). SII, NLR, PLR, and LMR all had a predictive value for periodontitis, with SII having the greatest Youden index and a better value than NLR, PLR, and LMR. Logistic regression analysis showed that SII and NLR were significantly correlated with periodontitis. We observed a significant difference in SII, NLR, PLR, and LMR among the grades in the periodontitis group (P<0.05). Periodontitis grading was positively correlated with SII, NLR, and PLR but negatively correlated with LMR. Conclusion We found a correlation between SII and periodontitis grading, which may be of clinical value in the assessment of disease progression rate.

Key words: periodontitis, grading, systemic immune-inflammatory index

CLC Number: 

  • R781.4

TrendMD: 

Fig 1

Localized magnified measurement of bone loss"

Tab 1

Comparison of the conditions of patients in the two groups at the initial consultation"

测量项目

牙周炎组

（n=131）

牙周健康组

（n=132）

P值
性别（男/女）57/7459/730.846
年龄/岁34.25±6.9133.35±6.670.190
PD/mm3.88±1.701.53±0.17<0.000 1
CAL/mm3.64±1.030.00±0.00<0.000 1
BI/mm2.62±0.501.11±0.28<0.000 1

Tab 2

Comparison of blood cell indicators between the two groups of patients"

指标牙周炎组（n=131）牙周健康组（n=132）P值
SII（×109/L）/ M（Q1，Q3）423.19（354.20，560.29）337.71（288.97，382.51）<0.000 1
NLR/xˉ±s2.04±0.741.52±0.34<0.000 1
PLR/xˉ±s131.95±41.77113.70±28.21<0.000 1
LMR/xˉ±s5.69±1.646.66±3.170.001

Tab 3

ROC curve analysis of SII, NLR, PLR and LMR for the diagnosis of periodontitis"

指标AUC（95% CI）约登指数截断值灵敏度/%特异度/%P值
SII0.758（0.700，0.815）0.409437.0746.294.7<0.000 1
NLR0.729（0.669，0.789）0.3562.0342.493.1<0.000 1
PLR0.636（0.569，0.703）0.241135.8840.284.0<0.000 1
LMR0.621（0.554，0.689）0.2316.4273.549.60.001

Fig 2

ROC curves of SII, NLR, PLR and LMR for the diagnosis of periodontitis"

Tab 6

Correlation of periodontitis grading with SII, NLR, PLR and LMR"

指标r值P值

SII

NLR

PLR

LMR

0.942

0.746

0.600

-0.429

<0.000 1

<0.000 1

<0.000 1

<0.000 1

Fig 3

Correlation analysis between SII, PLR and periodontitis grading"

Fig 4

Correlation analysis between LMR, NLR and periodontitis grading"

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