Int J Stomatol

Int J Stomatol ›› 2021, Vol. 48 ›› Issue (1): 12-17.doi: 10.7518/gjkq.2021004

• Periodontitis • Previous Articles     Next Articles

Role of endoplasmic reticulum stress in periodontitis affecting systemic diseases

Li Xin,Li Yan,Ding Xu,Xia Boyuan,Yu Weixian()   

  1. Dept. of Periodontics, Hospital of Stomatology, Jilin University & Jilin Provincial Key Labo-ratory of Tooth Development and Bone Remodeling, Changchun 130021, China
  • Received:2020-05-21 Revised:2020-08-13 Online:2021-01-01 Published:2021-01-20
  • Contact: Weixian Yu E-mail:yu-wei-xian@163.com
  • Supported by:
    This study was supported by International Cooperation Project of Science and Technology Development Plan of Jilin Province Science and Technology Department(20180414053GH);Natural Science Foundation of Jilin Province Science and Technology Department(20190201058JC);Science and Technology Project of Jilin Provincial Department of Finance(JCSZ2019378-1)

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Abstract:

Periodontitis is a chronic infectious disease that occurs in periodontal tissues, and its pathogenesis and effects on the system have been a hot issue in academic circles. Many scholars have shown that periodontitis is not only a common oral disease, but also a potential risk factor for systemic diseases. However, the mechanism of systemic diseases induced by periodontal disease is still unclear, which may be related to periodontal pathogens, inflammatory factors and endoplasmic reticulum stress. In recent years, studies have found that endoplasmic reticulum stress is an important pathway that mediates apoptosis and is closely related to systemic diseases. Some studies have shown that endoplasmic reticulum stress plays a regulatory role in the process of systemic diseases induced by periodontitis. However, few studies on the role of endoplasmic reticulum stress in periodontitis affecting systemic diseases have been found, and further exploration is needed. This article reviews the research progress of endoplasmic reticulum stress in periodontitis affecting systemic diseases and aims to explore the internal relationship between periodontitis and systemic diseases and provide new ideas for the prevention and treatment of periodontitis and its related systemic diseases.

Key words: periodontitis, endoplasmic reticulum stress, systemic disease

CLC Number: 

  • R782.2

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