Int J Stomatol

Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (6): 773-777.doi: 10.7518/gjkq.2013.06.020

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Effects of the WNT/β-catenin signal transduction pathway on periodontal tissue regeneration

Zheng Guiting, Xu Yan   

  1. Dept. of Periodontics, The Affiliated Hospital of Stomatology, School of Stomatology, Anhui Medical University; Key Laboratory of Oral Disease Research of Anhui Province, Hefei 230032, China
  • Received:2013-04-16 Revised:2013-08-02 Online:2013-11-01 Published:2013-11-01

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Abstract:

Periodontal tissues, including the periodontium, cementum, and alveolar bone, are significantly lost in moderate to severe periodontitis. The WNT/β-catenin signaling pathway promotes the proliferation and differentiation of periodontal ligament cells, osteoblasts, and cementoblasts to maintain the periodontium and improve the formation and regeneration of the cementum and alveolar bone. This review summarizes the WNT/β-catenin signaling pathway and its effects on the formation and regeneration of periodontal tissues.

Key words: WNT/β-catenin signal transduction pathway, periodontitis, regeneration, alveolar bone, cementum

CLC Number: 

  • Q 51

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