Int J Stomatol

Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (1): 42-46.doi: 10.7518/gjkq.2013.01.012

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Research progress on dispersin B

Chen Shanshan1，2,Qi Xia1，2, Zhao Lei 2.   

  1. 1. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China; 2. Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
  • Received:2012-02-08 Revised:2012-08-22 Online:2013-01-01 Published:2013-01-01
  • Contact: zhao lei

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Abstract:

Extracellular polysaccharide, synthesized by the bacteria in the biofilm, is the vital barrier which protect the biofilm against antimicrobial agents and host immune components. Therefore, researches focus on the antibiolfilm agents which exhibit the capability to degrade the extracellular polysaccharide or inhibit its synthesis are of high interest. Dispersin B, a β-N-acetylglucosaminidase produced by the gram-negative periodontal pathogen Actinobacillus actinomycetemcomitans, is reported to show the effect to degrade extracellular polysaccharide recently, and it may be possess the potential of using as an anti-biolfilm agents in clinic. This review will summarize the recent research progress on the structure, mechanism of action and application of dispersin B.

Key words: dispersin, dental plaque, periodontal disease, extracellar polysaccharide, biofilm detachment, anti-biofilm agent


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