Int J Stomatol

Inter J Stomatol ›› 2012, Vol. 39 ›› Issue (1): 69-72.doi: 10.3969/j.issn.1673-5749.2012.01.019

Previous Articles     Next Articles

Programmed death -1/programmed death -ligand 1 pathway and its regulation on oral chronic diseases

Zhang Jing1, Zhou Gang1，2.   

  1. 1. The State Key Laboratory Breeding Base of Basic Science of Stomatology（Hubei - MOST） & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China; 2. Dept. of Oral Medicine, Hospital of Stomatology, Wuhan University, Wuhan 430079, China
  • Received:2011-04-12 Revised:2011-11-12 Online:2012-01-01 Published:2012-01-01

RichHTML

1

PDF (PC)

1601

Abstract:

Programmed death-1（PD-1）/programmed death-ligand 1（PD-L1）, as the important member of B7- CD28 family, is a newly identified negative co-stimulatory pathway. It may play a critical immunoregulatory role, through inhibiting T cells activation and proliferation as well as cytokines production, in chronic diseases such as autoimmune diseases, chronic infections and tumors. Besides discussing the biological characteristics and functions of PD-1/PD-L1, this review mainly explores its regulation on oral chronic diseases including oral lichen planus, chronic periodontitis as well as oral malignant tumors and the therapeutic potential of PD-1/PD-L1 modulation in this filed.

Key words: programmed death-1/programmed death-ligand 1, T cell, treatment


TrendMD: 
[1] Liu Shiyi, Chen Zhong, Zhang Suxin. Progress in research into programmed death-1/programmed death-ligand 1 immunotherapy strategies in human papillomavirus-positive head and neck squamous cell carcinoma [J]. Int J Stomatol, 2024, 51(1): 21-27.
[2] Wang Nannan,He Hong,Hua Fang. Research progress on the risk factors of orthodontically induced enamel demineralization [J]. Int J Stomatol, 2024, 51(1): 91-98.
[3] Han Chong,He Dongning,Yu Feiyan,Wu Dongchao. Research progress on the mechanism and treatment of pain after oral implants [J]. Int J Stomatol, 2024, 51(1): 99-106.
[4] Sun Xu,Deng Zhennan,Wen Cai,Zhao Ying. Implant surface micromorphological changes after Er: YAG laser irradiation observed under scanning electron microscope [J]. Int J Stomatol, 2023, 50(6): 669-673.
[5] Wang Sujie,Tan Qin,Wei Yuan,Wang Jie,Fan Jie,Yue Erli.. Correlation analysis of serum angiopoietin-2 level with forkhead/winged helix transcription factor p3 regulatory T cells and disease activity in patients with oral lichen planus [J]. Int J Stomatol, 2023, 50(6): 674-678.
[6] Huang Yuanhong,Peng Xian,Zhou Xuedong.. Progress in research into the effect of Rhizoma Drynariae on the treatment of bone-related diseases in the oral cavity [J]. Int J Stomatol, 2023, 50(6): 679-685.
[7] Liu Yang,Yin Deqiang. Introducing a novel digital articulation workflow with high precision [J]. Int J Stomatol, 2023, 50(5): 499-505.
[8] Ji Xiao,Zhang Lan,Huang Dingming.. Diagnosis and treatment of odontogenic and non-odontogenic maxillary sinusitis [J]. Int J Stomatol, 2023, 50(5): 566-572.
[9] Zhao Yuanxi,Su Qin.. Application and development of supplementary techniques in removing the remaining filling materials of root canal retreatment [J]. Int J Stomatol, 2023, 50(5): 581-586.
[10] Gong Meiling,Cheng Xingqun,Wu Hongkun.. Research progress on the correlation between Parkinson’s disease and periodontitis [J]. Int J Stomatol, 2023, 50(5): 587-593.
[11] Liu Ting,Wu Xiuping.. Research progress on oral-craniomaxillofacial features and treatment of Down syndrome [J]. Int J Stomatol, 2023, 50(5): 618-622.
[12] Qin Yichun,Tan Xuelian,Huang Dingming.. Clinical research progress on glandular odontogenic cyst [J]. Int J Stomatol, 2023, 50(1): 100-107.
[13] Li Ting,Yang Xuecai,Wang Junwei.. Children with Williams-Beuren syndrome associated with cranial and maxillofacial deformity [J]. Int J Stomatol, 2023, 50(1): 108-113.
[14] Wang Qiqiu,Zhi Qinghui.. Research progress on treatments of enamel white spot lesions [J]. Int J Stomatol, 2022, 49(6): 717-723.
[15] Li Weiguang,Wu Yafei,Guo Shujuan.. Research progress on the use of inorganic nanoparticles in the diagnosis and treatment of periodontal disease [J]. Int J Stomatol, 2022, 49(6): 724-730.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .