国际口腔医学杂志

国际口腔医学杂志 ›› 2024, Vol. 51 ›› Issue (4): 425-432.doi: 10.7518/gjkq.2024059

• 牙周病学专栏 • 上一篇    下一篇

牙周炎与心力衰竭相关性的研究进展

刘诗礼(),赵蕾()   

  1. 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心四川大学华西口腔医院牙周病科 成都 610041
  • 收稿日期:2023-10-05 修回日期:2024-03-20 出版日期:2024-07-01 发布日期:2024-06-24
  • 通讯作者: 赵蕾
  • 作者简介:刘诗礼，住院医师，学士，Email：<email>1640286724@qq.com</email>
  • 基金资助:
    国家自然科学基金(81970944);四川省自然科学基金(2023NSFSC0553);成都市科技项目(2021-YF05-01864-SN)

Progress of research on the correlation between periodontitis and heart failure

Shili Liu(),Lei Zhao()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Periodontology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2023-10-05 Revised:2024-03-20 Online:2024-07-01 Published:2024-06-24
  • Contact: Lei Zhao
  • Supported by:
    National Natural Science Foundation of China(81970944);Sichuan Provincial Natural Science Foundation of China(2023NSFSC0553);Chengdu Science and Technology Project(2021-YF05-01864-SN)

RichHTML

24

PDF (PC)

691

摘要：

心力衰竭（HF）是各类心脏疾病的严重表现或终末阶段，严重影响患者的身心健康。目前对HF病因学的探索涉及多个方面，炎症对HF进程的影响是学者们关注的热点之一。牙周炎是菌斑生物膜引起的牙周软硬组织破坏性疾病，是常见的口腔疾病之一。已有报道指出牙周炎与心血管疾病（CVD）存在关联，但牙周炎与HF的关系及其机制的研究目前尚处于起步阶段。近年来发现牙周致病菌及其毒性产物可以通过直接和间接途径对心肌功能产生影响，从而影响HF的进程。本文对牙周炎与HF的相关性及其影响机制的研究进展进行综述，以期为牙周炎及CVD的共同防治提供一定的研究思路。

关键词: 心力衰竭, 牙周炎, 心肌重构, 心肌细胞

Abstract:

Heart failure (HF) is a serious manifestation or terminal stage of various heart diseases, seriously affecting the physical and mental health of patients. Its etiology is explored through many aspects, among which the influence of inflammation on the HF process is a scholarly research hotspot. Periodontitis is a destructive disease of periodontal soft and hard tissues caused by plaque biofilm and is one of the two major oral diseases. Periodontitis is reportedly associated significantly with cardiovascular disease (CVD). The relationship between periodontitis and HF and its mechanism remain in the initial stage of research. Periodontal pathogens and their toxic products can reportedly affect myocardial function directly and indirectly, thereby affecting HF progression. This work provides a review of the progress of research on perio-dontitis and HF to provide some research ideas for the joint prevention and treatment of periodontitis and CVD.

Key words: heart failure, periodontitis, cardiac remodeling, cardiomyocyte

中图分类号: 

  • R783

《口腔种植：治疗计划与临床决策》出版发行"

1 Sanz M, Marco Del Castillo A, Jepsen S, et al. Perio-dontitis and cardiovascular diseases: consensus report[J]. J Clin Periodontol, 2020, 47(3): 268-288.
2 Bozkurt B, Coats AJS, Tsutsui H, et al. Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Fai-lure Association of the European Society of Cardio-logy, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Fai-lure: Endorsed by the Canadian Heart Failure Socie-ty, Heart Failure Association of India, Cardiac So-ciety of Australia and New Zealand, and Chinese Heart Failure Association[J]. Eur J Heart Fail, 2021, 23(3): 352-380.
3 Hunt SA, Baker DW, Chin MH, et al. ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to revise the 1995 guidelines for the evaluation and management of heart failure)[J]. J Am Coll Cardiol, 2001, 38(7): 2101-2113.
4 中华医学会心血管病学分会心力衰竭学组, 中国医师协会心力衰竭专业委员会, 中华心血管病杂志编辑委员会. 中国心力衰竭诊断和治疗指南2018[J]. 中华心血管病杂志, 2018, 46(10): 760-789.
Heart Failure Group of Chinese Society of Cardiology, Heart Failure Professional Committee of Chinese Medical Doctor Association, Editorial Committee of Chinese Journal of Cardiology. Chinese guidelines for diagnosis and treatment of heart failure 2018[J]. Chin J Cardiol, 2018, 46(10): 760-789.
5 Fröhlich H, Herrmann K, Franke J, et al. Periodontitis in chronic heart failure[J]. Tex Heart Inst J, 2016, 43(4): 297-304.
6 Ziebolz D, Binner C, Reuschel F, et al. Comparison of periodontal parameters between patients with ischemic and dilative cardiomyopathy[J]. BMC Cardiovasc Disord, 2021, 21(1): 304.
7 Walther C, Wenzel JP, Schnabel RB, et al. Association between periodontitis and heart failure in the general population[J]. ESC Heart Fail, 2022, 9(6): 4189-4197.
8 Yan Y, Mao M, Li YQ, et al. Periodontitis is asso-ciated with heart failure: a population-based study (NHANES Ⅲ)[J]. Front Physiol, 2022, 13: 854606.
9 Lee HJ, Choi EK, Park JB, et al. Tooth loss predicts myocardial infarction, heart failure, stroke, and death[J]. J Dent Res, 2019, 98(2): 164-170.
10 Hamaya R, Yonetsu T, Aoyama N, et al. Contribution of periodontal health in cardiovascular secon-dary prevention: analyses on hospitalized patients in cardiology units[J]. J Clin Periodontol, 2023, 50(6): 708-716.
11 Schulze-Späte U, Mizani I, Salaverry KR, et al. Perio-dontitis and bone metabolism in patients with advanced heart failure and after heart transplantation[J]. ESC Heart Fail, 2024, 4(2): 169-177.
12 Aoyama N, Kure K, Minabe M, et al. Increased heart failure prevalence in patients with a high antibody level against periodontal pathogen[J]. Int Heart J, 2019, 60(5): 1142-1146.
13 Molinsky RL, Yuzefpolskaya M, Norby FL, et al. Periodontal status, C-reactive protein, NT-proBNP, and incident heart failure: the ARIC study[J]. JACC Heart Fail, 2022, 10(10): 731-741.
14 Muñoz Aguilera E, Suvan J, Buti J, et al. Periodontitis is associated with hypertension: a systematic review and meta-analysis[J]. Cardiovasc Res, 2020, 116(1): 28-39.
15 Struppek J, Schnabel RB, Walther C, et al. Periodontitis, dental plaque, and atrial fibrillation in the Hamburg City Health Study[J]. PLoS One, 2021, 16(11): e0259652.
16 Matsui S, Maruhashi T, Kishimoto S, et al. Poor tooth brushing behavior is associated with high risk of cardiovascular events: a prospective observatio-nal study[J]. Int J Cardiol, 2022, 350: 111-117.
17 Park SY, Kim SH, Kang SH, et al. Improved oral hygiene care attenuates the cardiovascular risk of oral health disease: a population-based study from Korea[J]. Eur Heart J, 2019, 40(14): 1138-1145.
18 Chang Y, Woo HG, Park J, et al. Improved oral hygiene care is associated with decreased risk of occurrence for atrial fibrillation and heart failure: a nationwide population-based cohort study[J]. Eur J Prev Cardiol, 2020, 27(17): 1835-1845.
19 Farrugia C, Stafford GP, Potempa J, et al. Mechanisms of vascular damage by systemic dissemination of the oral pathogen Porphyromonas gingivalis [J]. FEBS J, 2021, 288(5): 1479-1495.
20 Chen TS, Kuo CH, Battsengel S, et al. Adipose-derived stem cells decrease cardiomyocyte damage induced by Porphyromonas gingivalis endotoxin through suppressing hypertrophy, apoptosis, fibrosis, and MAPK markers[J]. Environ Toxicol, 2018, 33(4): 508-513.
21 Chen TS, Battsengel S, Kuo CH, et al. Stem cells rescue cardiomyopathy induced by P. gingivalis-LPS via miR-181b[J]. J Cell Physiol, 2018, 233(8): 5869-5876.
22 Gutiérrez-Venegas G, Torras-Ceballos A, Gómez-Mora JA, et al. Luteolin, quercetin, genistein and quercetagetin inhibit the effects of lipopolysaccharide obtained from Porphyromonas gingivalis in H9c2 cardiomyoblasts[J]. Cell Mol Biol Lett, 2017, 22: 19.
23 Fan MH, Wong KL, Wu S, et al. Preconditioning with Porphyromonas gingivalis lipopolysaccharide may confer cardioprotection and improve recovery of the electrically induced intracellular calcium transient during ischemia and reperfusion[J]. J Periodontal Res, 2010, 45(1): 100-108.
24 Matsuo I, Kawamura N, Ohnuki Y, et al. Role of TLR4 signaling on Porphyromonas gingivalis LPS-induced cardiac dysfunction in mice[J]. PLoS One, 2022, 17(6): e0258823.
25 Matsuo I, Ohnuki Y, Suita, et al. Effects of chronic Porphylomonas gingivalis lipopolysaccharide infusion on cardiac dysfunction in mice[J]. J Oral Bio-sci, 2021, 63(4): 394-400.
26 刘革铭, 马洪俊, 刘毅, 等. 心力衰竭的机制及诊疗的研究[J]. 医学信息, 2022, 35(10): 91-94.
Liu GM, Ma HJ, Liu Y, et al. Mechanism, diagnosis and treatment of heart failure[J]. J Med Inf, 2022, 35(10): 91-94.
27 Köse O, Arabacı T, Gedikli S, et al. Biochemical and histopathologic analysis of the effects of perio-dontitis on left ventricular heart tissues of rats[J]. J Periodontal Res, 2017, 52(2): 176-185.
28 Wu HC, Yeh YL, Kuo WW, et al. P38 mitogen-activated protein kinase pathways are involved in the hypertrophy and apoptosis of cardiomyocytes induced by Porphyromonas gingivalis conditioned medium[J]. Cell Biochem Funct, 2008, 26(2): 246-255.
29 Lee SD, Chang SH, Kuo WH, et al. Role of mitogen-activated protein kinase kinase in Porphyromo-nas gingivalis-induced myocardial cell hypertrophy and apoptosis[J]. Eur J Oral Sci, 2006, 114(2): 154-159.
30 Lee SD, Kuo WW, Lin DY, et al. Role of calcineurin in Porphyromonas gingivalis-induced myocar-dial cell hypertrophy and apoptosis[J]. J Biomed Sci, 2006, 13(2): 251-260.
31 李露, 李雨霖, 柳燕, 等. 牙周炎加重主动脉弓缩窄诱导的小鼠心肌肥厚[J]. 上海交通大学学报(医学版), 2022, 42(9): 1275-1287.
Li L, Li YL, Liu Y, et al. Periodontitis aggravates transverse aortic constriction-induced cardiac hypertrophy in mice[J]. J Shanghai Jiao Tong Univ Med Sci, 2022, 42(9): 1275-1287.
32 Srisuwantha R, Shiheido Y, Aoyama N, et al. Porphyromonas gingivalis elevated high-mobility group box 1 levels after myocardial infarction in mice[J]. Int Heart J, 2017, 58(5): 762-768.
33 Shiheido Y, Maejima Y, Suzuki JI, et al. Porphyromonas gingivalis, a periodontal pathogen, enhan-ces myocardial vulnerability, thereby promoting post-infarct cardiac rupture[J]. J Mol Cell Cardiol, 2016, 99: 123-137.
34 Goette A. Is periodontitis a modifiable risk factor for atrial fibrillation substrate[J]. JACC Clin Electrophysiol, 2023, 9(1): 54-56.
35 Yu G, Yu Y, Li YN, et al. Effect of periodontitis on susceptibility to atrial fibrillation in an animal model[J]. J Electrocardiol, 2010, 43(4): 359-366.
36 Zhang ZX, Chen F, Gao XY, et al. Effects of oral inflammatory diseases and oral hygiene on atrial fibrillation: a systematic review[J]. Int J Clin Pract, 2023, 2023: 1750981.
[1] 漆美瑶,祁星颖,周欣奕,谭震,袁泉. 大麻二酚联合米诺环素对牙周炎治疗作用的实验研究[J]. 国际口腔医学杂志, 2024, 51(4): 392-400.
[2] 陈梦洁,刘小乐,朱丽雷. 牙周炎患者牙周支持治疗对血细胞指标影响的回顾性研究[J]. 国际口腔医学杂志, 2024, 51(4): 401-405.
[3] 马玉,左玉,刘建华. 抗菌光动力疗法与全身抗菌药物辅助治疗牙周炎疗效比较的Meta分析[J]. 国际口腔医学杂志, 2024, 51(4): 406-415.
[4] 杨再目,曹沛,刘振华,栾庆先. 血浆无细胞线粒体外线粒体DNA与牙周炎临床指标的相关性研究[J]. 国际口腔医学杂志, 2024, 51(3): 288-295.
[5] 马瑜鸿,赵蕾. 微创非手术牙周治疗技术的临床研究进展[J]. 国际口腔医学杂志, 2024, 51(2): 227-232.
[6] 傅豫, 何薇, 黄兰. 铁死亡在口腔疾病中的研究进展[J]. 国际口腔医学杂志, 2024, 51(1): 36-44.
[7] 罗晓洁,王德续,陈晓涛. 基于生物信息学分析铁死亡调控基因与牙周炎的关系[J]. 国际口腔医学杂志, 2023, 50(6): 661-668.
[8] 黄元鸿,彭显,周学东. 骨碎补在治疗口腔骨相关疾病的研究进展[J]. 国际口腔医学杂志, 2023, 50(6): 679-685.
[9] 龚美灵,程兴群,吴红崑. 牙周炎与帕金森病相关性的研究进展[J]. 国际口腔医学杂志, 2023, 50(5): 587-593.
[10] 孙佳,韩烨,侯建霞. 白细胞介素-6-铁调素信号轴调控牙周炎相关性贫血致病机制的研究进展[J]. 国际口腔医学杂志, 2023, 50(3): 329-334.
[11] 刘体倩,梁星,刘蔚晴,李晓虹,朱睿. 咬合创伤在牙周炎发生发展中的作用及机制的研究进展[J]. 国际口腔医学杂志, 2023, 50(1): 19-24.
[12] 李琼,于维先. 白藜芦醇治疗牙周炎及其生物利用度的研究进展[J]. 国际口腔医学杂志, 2023, 50(1): 25-31.
[13] 黄伟琨,徐秋艳,周婷. 黄芩苷抑制脂多糖促巨噬细胞氧化应激损伤作用的研究[J]. 国际口腔医学杂志, 2022, 49(5): 521-528.
[14] 周剑鹏,谢旭东,赵蕾,王骏. 辅助性T细胞17及白细胞介素17在牙周炎中的作用及机制的研究进展[J]. 国际口腔医学杂志, 2022, 49(5): 586-592.
[15] 陈荟宇,白明茹,叶玲. 信号素3A与口腔常见病关系的研究进展[J]. 国际口腔医学杂志, 2022, 49(5): 593-599.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 黄汉尧, 王梦娇, 吴昊, 蒋莉萍, 张文婧, 韦杉, 尹恒. 腭咽闭合不全相关生存质量量表信度与效度的验证[J]. 国际口腔医学杂志, 2018, 45(2): 177 -184 .
[2] 王勇. 全口义齿数字化技术分析[J]. 国际口腔医学杂志, 2020, 47(1): 1 -9 .