国际口腔医学杂志

国际口腔医学杂志 ›› 2024, Vol. 51 ›› Issue (4): 401-405.doi: 10.7518/gjkq.2024052

• 牙周病学专栏 • 上一篇    下一篇

牙周炎患者牙周支持治疗对血细胞指标影响的回顾性研究

陈梦洁1(),刘小乐2,朱丽雷2()   

  1. 1.湖南中医药大学研究生院 长沙 410208
    2.长沙市口腔医院牙周病科 长沙 410000
  • 收稿日期:2023-03-15 修回日期:2024-01-15 出版日期:2024-07-01 发布日期:2024-06-24
  • 通讯作者: 朱丽雷
  • 作者简介:陈梦洁，医师，硕士，Email：<email>1174052274@qq.com</email>
  • 基金资助:
    湖南省卫生健康委员会卫生科研课题(D202308017691)

The effect of supportive periodontal therapy on blood cell indicators in patients with periodontitis： a retrospective study

Mengjie Chen1(),Xiaole Liu2,Lilei Zhu2()   

  1. 1.Graduate School, Hunan University of Chinese Medicine, Changsha 410208, China
    2.Dept. of Periodontology, Changsha Stomatological Hospital, Changsha 410000, China
  • Received:2023-03-15 Revised:2024-01-15 Online:2024-07-01 Published:2024-06-24
  • Contact: Lilei Zhu
  • Supported by:
    Scientific Research Project of Health Commission of Hunan Province(D202308017691)

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摘要：

目的 探讨牙周炎患者牙周支持治疗对血细胞指标的影响。 方法 按照纳入及排除标准，选取2014年1月—2022年3月于长沙市口腔医院就诊且被确诊为牙周炎的患者为研究对象。根据是否定期进行牙周支持治疗，分为定期支持治疗组（74例）和不定期支持治疗组（76例），对比两组血细胞指标水平变化。 结果 定期支持治疗组中性粒细胞计数（N）、白细胞计数（WBC）、血小板计数（PLT）、全身免疫炎症指数（SII）均低于治疗前（P<0.05）；平均红细胞血红蛋白浓度（MCHC）、平均红细胞体积（MCV）、平均血小板体积（MPV）均高于治疗前（P<0.05）；血红蛋白浓度（HGB）相对稳定（P>0.05）。治疗后不定期支持治疗组SII较治疗前下降，MPV、MCV则增大（P<0.05）。两组患者治疗后WBC、N、PLT、SII、MCV、MCHC和MPV之间差异有统计学意义（P<0.05）。在5年随访期间，定期支持治疗组WBC、N、PLT、SII呈下降趋势；MCHC、MPV、MCV呈增长趋势。 结论 积极的牙周支持治疗能改善牙周炎患者的血液学参数，缓解体内免疫与炎症失衡状态，有利于治疗效果的维护与提高。

关键词: 牙周炎, 牙周支持治疗, 血细胞

Abstract:

Objective This study aimed to investigate the effect of supportive periodontal therapy (SPT) on blood cell indicators in patients with periodontitis. Methods In accordance with the inclusion and exclusion criteria, patients who were diagnosed with periodontitis at Changsha Stomatological Hospital from January 2014 to March 2022 were included. On the basis of whether SPT was performed on patients or not, patients were divided into maintenance group (74 patients) and nonmaintenance group (76 patients) to compare the differences in blood cell indicators between the two groups. Results After treatment, the neutrophil count (N), white blood cell count (WBC), platelet count (PLT), and systemic immune-inflammation index (SII) of the maintenance group decreased (P<0.05); the mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), and mean platelet volume (MPV) increased (P<0.05); the hemoglobin (HGB) showed no significant change (P>0.05). The SII of the nonmaintenance group decreased, whereas the MPV and MCV increased (P<0.05). By comparing the changes in blood cell indicators, we found significant differences in WBC, N, PLT, SII, MCV, MCHC, and MPV between the two groups (P<0.05). During the 5-year follow-up period, a decreasing trend in WBC, N, PLT, and SII and an increasing trend in MCHC, MPV, and MCV in the maintenance group were observed. Conclusion Active SPT could improve the hematological parameters of patients, alleviate the immune and inflammatory imbalance, and benefit the maintenance and improvement of the treatment effect.

Key words: periodontitis, supportive periodontal therapy, blood cell

中图分类号: 

  • R781.4

表 1

两组患者初诊时情况比较"

项目定期支持治疗组不定期支持治疗组P值
样本数7476
性别（男/女）38/3639/370.997

年龄（岁，xˉ±s）

PD（mm，xˉ±s）

AL（mm，xˉ±s）

BI（xˉ±s）

43.22±10.04

3.45±0.38

3.57±0.35

2.12±0.77

42.70±10.00

3.49±0.31

3.63±0.30

2.13±0.69

0.717

0.492

0.330

0.545

表 2

两组患者治疗前后牙周临床指标比较 (xˉ±s)"

牙周临床指标定期支持治疗组不定期支持治疗组
治疗前末次治疗后治疗前末次治疗后
PD（mm）3.45±0.382.52±0.44*#3.49±0.313.41±0.31
AL（mm）3.57±0.352.73±0.45*#3.63±0.303.57±0.28
BI2.12±0.771.38±0.53*#2.13±0.692.06±0.56

表 3

两组患者治疗前后血细胞指标比较 (xˉ±s)"

血细胞指标定期支持治疗组不定期支持治疗组
治疗前末次治疗后治疗前末次治疗后
N（109/L）3.92±1.323.18±1.11*#3.79±1.013.60±1.23
WBC（109/L）6.35±1.635.60±1.52*#6.17±1.486.11±1.54
MCV（fL）93.10±4.5296.75±6.90*#93.25±5.5994.12±5.69*
HGB（g/L）142.16±12.36142.35±15.00140.72±15.52140.84±14.07
MCHC（g/L）317.97±7.66322.77±10.27*#318.34±7.00318.11±7.36
PLT（109/L）232.86±56.77219.55±53.71*#242.38±44.64239.24±45.25
MPV（fL）8.42±0.869.03±0.90*#8.33±0.888.69±0.76*
SII（109/L）503.93±258.01379.76±187.06*#517.69±197.23456.45±200.46*

图1

血细胞变化趋势A~F分别为WBC和N、PLT、SII、MCHC、MPV和MCV。"

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